Mouse Myeloperoxidase DuoSet ELISA, 15 Plate

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications ELISA
Conjugate
Biotin

Order Details

Mouse Myeloperoxidase DuoSet ELISA, 15 Plate Summary

Source
N/A
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
Mpo

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DY3667.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse Myeloperoxidase DuoSet ELISA, 15 Plate

  • EC 1.11.1
  • EC 1.11.1.7
  • MPO
  • Myeloperoxidase

Background

Myeloperoxidase (MPO) is a heme-containing enzyme belonging to the XPO subfamily of peroxidases. It is an abundant neutrophil and monocyte glycoprotein that catalyzes the hydrogen peroxide dependent formation of hypochlorus acid (HOCl) and other reactive species. Enzymatically active MPO is a disulfide-linked tetramer that contains two heme groups and two copies each of the heavy and light chains. MPO binds Albumin, MMR, Cytokeratin 1 on vascular endothelial cells, HMW Kininogen, and Integrin CD11b/CD18 on neutrophils. These interactions promote MPO clearance, a reduction of nitric oxide and bradykinin levels, reduced vasodilation, and continued neutrophil activation. Neutrophil MPO is stored in cytoplasmic azurophilic granules. Upon cellular activation and degranulation, MPO is delivered into phagosomes where it is required for the killing of phagocytosed bacteria. Activated neutrophils also release granule contents extracellularly. Elevated plasma MPO levels have been associated with a variety of clinical conditions including systemic inflammation, eclampsia, risk of cardiovascular events, vascular endothelial dysfunction, severity of multiple sclerosis, and prospective mortality and oxidative stress during hemodialysis.

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DY3667
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Applications: ELISA

Publications for Myeloperoxidase/MPO (DY3667)(93)

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Transgenic Mouse.


Filter By Application
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Filter By Species
Human
(1)
Mouse
(86)
Rat
(3)
Transgenic Mouse
(4)
All Species
Showing Publications 1 - 10 of 93. Show All 93 Publications.
Publications using DY3667 Applications Species
Thapa, A;Nallapu, A;Mougboh, N;Nedunchezian, S;Talati, K;Yang, B;Hyun, J;Sanchez, JM;Seet, CS;Koon, HW;Li, Z;Ciorba, MA;Michelsen, K;Kulkarni, HS;Kulkarni, DH; Mucosally sourced complement factor B modulates the host response to colitis bioRxiv : the preprint server for biology 2026-01-01 [PMID: 41509372] (Mouse) Mouse
Ohanyan, M;Balazs, GI;Hullahalli, K;Fernandez Pacheco, D;Lomeli, C;Dailey, KG;Mettert, E;Hooker-Romero, D;Schwiesow, L;Kiley, PJ;Waldor, MK;Auerbuch, V; IscR-mediated sensing of iron-sulfur cluster demand coordinates virulence gene expression in Yersinia pseudotuberculosis bioRxiv : the preprint server for biology 2025-10-17 [PMID: 41279696] (Mouse) Mouse
Song, YN;Kim, SH;Ro, H;Yun, SH;Oh, ES;Kim, DY;Ryu, HW;Hong, ST;Lee, DY;Lee, SU; Black ginseng extract alleviates particulate matter-induced airway inflammation by suppressing the ROS/NLRP3/caspase-1 pathway in macrophages Journal of ethnopharmacology 2025-11-06 [PMID: 41205640] (Mouse) Mouse
Beegam, S;Zaaba, NE;Elzaki, O;Nemmar, A; ?-Bisabolol alleviates diesel exhaust particle-induced lung injury and mitochondrial dysfunction by regulating inflammatory, oxidative stress, and apoptotic biomarkers through the c-Jun N-terminal kinase signaling pathway Frontiers in pharmacology 2025-01-03 [PMID: 39830335] (Mouse) Mouse
Hamadi, N;Al?Salam, S;Beegam, S;Zaaba, N;Elzaki, O;Nemmar, A; Chronic Exposure to Two Regimens of Waterpipe Smoke Elicits Lung Injury, Genotoxicity, and Mitochondrial Impairment with the Involvement of MAPKs Activation in Mice International journal of molecular sciences 2025-01-06 [PMID: 39796284] (Mouse) Mouse
Lee, IS;Fegan, JE;Currie, EG;Bojagora, A;Leung, NY;Rancourt, D;Taha, MK;Schryvers, AB;Gray-Owen, SD; Human transferrin and lactoferrin cooperatively support Neisseria meningitidis colonization in the murine nasopharynx bioRxiv : the preprint server for biology 2024-09-07 [PMID: 39282262] (Transgenic Mouse) Transgenic Mouse
Nicola, T;Wenger, N;Xu, X;Evans, M;Qiao, L;Rezonzew, G;Yang, Y;Jilling, T;Margaroli, C;Genschmer, K;Willis, K;Ambalavanan, N;Blalock, JE;Gaggar, A;Lal, CV; A lactobacilli-based inhaled live biotherapeutic product attenuates pulmonary neutrophilic inflammation Nature communications 2024-08-19 [PMID: 39160214] (Mouse) Mouse
Das, S;Kaminski, TW;Schlegel, BT;Bain, W;Hu, S;Patel, A;Kale, SL;Chen, K;Lee, JS;Mallampalli, RK;Kagan, VE;Rajasundaram, D;McVerry, BJ;Sundd, P;Kitsios, GD;Ray, A;Ray, P; Neutrophils and galectin-3 defend mice from lethal bacterial infection and humans from acute respiratory failure Nature communications 2024-06-03 [PMID: 38830855] (Mouse) Mouse
Kim, YY;Hur, G;Jang, HJ;Jeong, S;Lee, SW;Lee, SJ;Rho, MC;Kim, SH;Lee, S; Ferulic Acid Derivatives Ameliorate Intestine Barrier Destruction by Alleviating Inflammatory Responses in Dextran Sulfate Sodium-Induced Inflammatory Bowel Disease Toxics 2024-04-03 [PMID: 38668491] (Mouse) Mouse
Zeng, FL;Zhang, Y;Wang, ZH;Zhang, H;Meng, XT;Wu, YQ;Qian, ZZ;Ding, YH;Li, J;Ma, TT;Huang, C; Neutrophil extracellular traps promote acetaminophen-induced acute liver injury in mice via AIM2 Acta pharmacologica Sinica 2024-04-08 [PMID: 38589685] (Mouse) Mouse
Show All 93 Publications.

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FAQs for Myeloperoxidase/MPO (DY3667). (Showing 1 - 1 of 1 FAQs).

  1. What is the difference between the Quantikine and Duoset ELISA kits?
    • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

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Bioinformatics

Gene Symbol Mpo