Mouse Myeloperoxidase DuoSet ELISA, 15 Plate



Product Details

Reactivity MuSpecies Glossary
Applications ELISA

Order Details

Mouse Myeloperoxidase DuoSet ELISA, 15 Plate Summary

Assay Type
Solid Phase Sandwich ELISA
See PDF Datasheet for details
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details


Application Notes
No significant interference observed with available related molecules.
Read Publications using DY3667.

Packaging, Storage & Formulations

Store the unopened product at 2 - 8 °C. Do not use past expiration date.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse Myeloperoxidase DuoSet ELISA, 15 Plate

  • EC 1.11.1
  • EC
  • MPO
  • Myeloperoxidase


Myeloperoxidase (MPO) is a heme-containing enzyme belonging to the XPO subfamily of peroxidases. It is an abundant neutrophil and monocyte glycoprotein that catalyzes the hydrogen peroxide dependent formation of hypochlorus acid (HOCl) and other reactive species. Enzymatically active MPO is a disulfide-linked tetramer that contains two heme groups and two copies each of the heavy and light chains. MPO binds Albumin, MMR, Cytokeratin 1 on vascular endothelial cells, HMW Kininogen, and Integrin CD11b/CD18 on neutrophils. These interactions promote MPO clearance, a reduction of nitric oxide and bradykinin levels, reduced vasodilation, and continued neutrophil activation. Neutrophil MPO is stored in cytoplasmic azurophilic granules. Upon cellular activation and degranulation, MPO is delivered into phagosomes where it is required for the killing of phagocytosed bacteria. Activated neutrophils also release granule contents extracellularly. Elevated plasma MPO levels have been associated with a variety of clinical conditions including systemic inflammation, eclampsia, risk of cardiovascular events, vascular endothelial dysfunction, severity of multiple sclerosis, and prospective mortality and oxidative stress during hemodialysis.

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Publications for Myeloperoxidase/MPO (DY3667)(70)

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Transgenic Mouse.

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Showing Publications 1 - 10 of 70. Show All 70 Publications.
Publications using DY3667 Applications Species
EG Foerster, DKL Tsang, S Goyal, SJ Robertson, LM Robert, H Maughan, CJ Streutker, SE Girardin, DJ Philpott ATG16L1 protects from interferon-gamma-induced cell death in the small intestinal crypt Mucosal Immunology, 2023;0(0):. 2023 [PMID: 36792009] (Transgenic Mouse) Transgenic Mouse
JL Roncaioli, JP Babirye, RA Chavez, FL Liu, EA Turcotte, AY Lee, CF Lesser, RE Vance A hierarchy of cell death pathways confers layered resistance to shigellosis in mice Elife, 2023;12(0):. 2023 [PMID: 36645406] (Mouse) Mouse
N Trti?, M Mori, S Matsui, N Nakamura, H Fukamachi, M Kurosawa, H Morisaki, Y Maruoka, M Mayers, N Okahashi, H Kuwata, M Itsumi Oral commensal bacterial flora is responsible for peripheral differentiation of neutrophils in the oral mucosa in the steady state Journal of oral biosciences, 2022;0(0):. 2022 [PMID: 36464149] (Mouse) Mouse
RA Keogh, AL Haeberle, CJ Langouët-A, JS Kavanaugh, EP Schmidt, GD Moore, AR Horswill, KS Doran Group B Streptococcus adaptation promotes survival in a hyperinflammatory diabetic wound environment Science Advances, 2022;8(45):eadd3221. 2022 [PMID: 36367946] (Mouse) Mouse
NM Wenger, L Qiao, T Nicola, Z Nizami, X Xu, KA Willis, N Ambalavana, A Gaggar, CV Lal Efficacy of a Probiotic and Herbal Supplement in Models of Lung Inflammation Microorganisms, 2022;10(11):. 2022 [PMID: 36363728] (Mouse) Mouse
T Hoyler, B Bannert, C André, D Beck, T Boulay, D Buffet, N Caesar, T Calzascia, J Dawson, D Kyburz, R Hennze, C Huppertz, A Littlewood, P Loetscher, KD Mertz, S Niwa, G Robert, JS Rush, G Ruzzante, S Sarret, T Stein, I Touil, G Wieczorek, G Zipfel, S Hawtin, T Junt Nonhematopoietic IRAK1 drives arthritis via neutrophil chemoattractants JCI Insight, 2022;7(13):. 2022 [PMID: 35801586] (Mouse) Mouse
WJ Kelley, KM Wragg, J Chen, T Murthy, Q Xu, MT Boyne Ii, JR Podojil, A Elhofy, DR Goldstein Nanoparticles reduce monocytes within the lungs to improve outcomes after influenza virus infection in aged mice JCI Insight, 2022;0(0):. 2022 [PMID: 35737459] (Mouse) Mouse
C Conrad, D Yildiz, SJ Cleary, A Margraf, L Cook, U Schlomann, B Panaretou, JL Bowser, H Karmouty-Q, J Li, NK Berg, SC Martin, A Aljohmani, SF Moussavi-H, KM Wang, JJ Tian, M Magnen, C Valet, L Qiu, JP Singer, HK Eltzschig, CAPSys Stu, W Bertrams, S Herold, N Suttorp, B Schmeck, ZT Ball, A Zarbock, MR Looney, JW Bartsch ADAM8 signaling drives neutrophil migration and ARDS severity JCI Insight, 2022;7(3):. 2022 [PMID: 35132956] (Mouse) Mouse
N Kim, S Lee, J Kang, TK Kwon, D Khang, SH Kim Gomisin M2 alleviates psoriasis?like skin inflammation by inhibiting inflammatory signaling pathways Molecular Medicine Reports, 2021;24(6):. 2021 [PMID: 34664681] (Human) Human
Y Bian, J Lei, J Zhong, B Wang, Y Wan, J Li, C Liao, Y He, Z Liu, K Ito, B Zhang Kaempferol Reduces Obesity, Prevents Intestinal Inflammation, and Modulates Gut Microbiota in High-fat Diet Mice: Kaempferol reduce inflammation and dysbacteria The Journal of nutritional biochemistry, 2021;0(0):108840. 2021 [PMID: 34419569] (Mouse) Mouse
Show All 70 Publications.

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Gene Symbol Mpo