Mouse FGF-21 DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse FGF-21 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Fgf21

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse FGF-21 DuoSet ELISA, 15 Plate

• FGF21
• FGF-21
• fibroblast growth factor 21

Background

FGF-21 (Fibroblast Growth Factor 21) is a member of an FGF subfamily that also includes FGF-19 and FGF-23. FGF-19 subfamily members lack a heparin binding domain, enabling them to freely circulate as endocrine factors and diffuse within tissues. FGF-21 signals through Klotho beta in complex with FGF receptors. It regulates cellular metabolism including glucose uptake in adipocytes and cellular sensitivity to insulin. It is basally expressed in the pancreas, thymus, liver, and adipose tissue and is upregulated in liver, muscle, and fat in obesity and diabetes. FGF-21 also plays a role in cell survival and proliferation, mesenchymal stem cell differentiation, circadian rhythm, and controlling reproductive capacity.

Publications for FGF-21 (DY3057)(5)

Publications using DY3057

• Carloni, S;Nasoni, MG;Casabianca, A;Orlandi, C;Capobianco, L;Iaconisi, GN;Cerioni, L;Burattini, S;Benedetti, S;Reiter, RJ;Balduini, W;Luchetti, F; Melatonin Reduces Mito-Inflammation in Ischaemic Hippocampal HT22 Cells and Modulates the cGAS-STING Cytosolic DNA Sensing Pathway and FGF21 Release Journal of cellular and molecular medicine 2024-12-01 [PMID: 39707673] (Mouse)
• Reyes, J;Zhao, Y;Pandya, K;Yap, GS; Growth differentiation factor-15 is an IFN-? regulated mediator of infection-induced weight loss and the hepatic FGF21 response Brain, behavior, and immunity 2023-11-26 [PMID: 38013040] (Mouse)
• Anderson, JM;Arnold, WD;Huang, W;Ray, A;Owendoff, G;Cao, L; Long-term effects of a fat-directed FGF21 gene therapy in aged female mice Gene therapy 2023-09-12 [PMID: 37699965] (Mouse)
• LY Herat, AL Magno, C Rudnicka, J Hricova, R Carnagarin, NC Ward, A Arcambal, MG Kiuchi, GA Head, MP Schlaich, VB Matthews SGLT2 Inhibitor-Induced Sympathoinhibition: A Novel Mechanism for Cardiorenal Protection JACC Basic Transl Sci, 2020-01-29;5(2):169-179. 2020-01-29 [PMID: 32140623] (Mouse)
• Camila O Souza Palmitoleic Acid Improves Metabolic Functions in Fatty Liver by PPAR?-Dependent AMPK Activation J. Cell. Physiol, 2017-03-24;0(0):. 2017-03-24 [PMID: 27925195] (Mouse)

Bioinformatics

• Gene Symbol: Fgf21