Mouse CCL5/RANTES DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse CCL5/RANTES DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Ccl5

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse CCL5/RANTES DuoSet ELISA, 15 Plate

• CCL5
• chemokine (C-C motif) ligand 5
• D17S136Enormally T-expressed, and presumably secreted
• EoCP
• Eosinophil chemotactic cytokine
• RANTES
• SISd
• SIS-delta
• small inducible cytokine A5 (RANTES)
• small inducible cytokine subfamily A (Cys-Cys), member 5
• Small-inducible cytokine A5
• T cell-specific protein P228
• T-cell specific protein p288
• TCP228T-cell-specific protein RANTES

Background

RANTES (Regulated upon Activation, Normal T cell-expressed, and presumably Secreted), also known as CCL5, a member of the CC chemokine family of inflammatory and immunoregulatory cytokines, initially discovered by subtractive hybridization as a T cell-specific molecule (1, 2). Mouse RANTES cDNA encodes a 91 amino acid (aa) residue precursor protein with a presumed signal peptide of 23 aa residues that is cleaved to generate the 68 aa residue mature protein (3). At the amino acid sequence level, mouse RANTES is 84% identical to human RANTES. Both human and mouse RANTES exhibit cross species activity. Naturally occurring human RANTES has been found to be a mixture of the 68 aa residue mature protein and a 66 aa residue amino-terminally truncated form (4, 5). Cells known to express RANTES include keratinocytes, eosinophils, platelets, endothelium, fibroblasts, respiratory epithelium, astrocytes, vascular smooth muscle, and CD4⁺ and CD8⁺ T cells (6-14). As suggested by its acronym, RANTES production by the various cell types is induced in response to cytokine stimulation (8-13). 

Like other CC chemokines, RANTES is a monocyte chemoattractant (2). RANTES can also chemoattract unstimulated CD4⁺/CD45RO⁺ memory T cells and stimulated CD4⁺ and CD8⁺ T cells with the naive and memory phenotypes. In addition, RANTES can chemoattract and degranulate eosinophils, as well as chemoattract and induce histamine release from basophils. Human RANTES has been shown to be an inhibitor of HIV infection of human mononuclear cells (15, 16). Several CC chemokine receptors, including CCR-1, CCR-3, CCR-4, and CCR-5, have been shown to bind RANTES and subsequently to transduce a signal by increasing the intracellular calcium ion level (2, 17-21).

Publications for CCL5/RANTES (DY478)(93)

Publications using DY478

• Cheung, EC;Strathdee, D;Stevenson, D;Coomes, J;Blyth, K;Vousden, KH; Regulation of ROS signaling by TIGAR induces cancer-modulating responses in the tumor microenvironment Proceedings of the National Academy of Sciences of the United States of America 2024-12-10 [PMID: 39636862] (Mouse)
• Ho, MH;Tsai, YJ;Chen, CY;Yang, A;Burnouf, T;Wang, Y;Chiang, YH;Hoffer, BJ;Chou, SY; CCL5 is essential for axonogenesis and neuronal restoration after brain injury Journal of biomedical science 2024-09-17 [PMID: 39285280] (Mouse)
• Gabele, L;Bochow, I;Rieke, N;Sieben, C;Michaelsen-Preusse, K;Hosseini, S;Korte, M; H7N7 viral infection elicits pronounced, sex-specific neuroinflammatory responses in vitro Frontiers in cellular neuroscience 2024-08-07 [PMID: 39171200] (Mouse)
• Spielbauer, J;Glotfelty, E;Sarlus, H;Harris, RA;Heijtz, RD;Karlsson, TE; Bacterial peptidoglycan signalling in microglia: Activation by MDP via the NF-?B/MAPK pathway Brain, behavior, and immunity 2024-07-04 [PMID: 38971207] (Mouse)
• Lim, J;Rodriguez, R;Williams, K;Silva, J;Gutierrez, AG;Tyler, P;Baharom, F;Sun, T;Lin, E;Martin, S;Kayser, BD;Johnston, RJ;Mellman, I;Delamarre, L;West, NR;Müller, S;Qu, Y;Heger, K; The exonuclease TREX1 constitutes an innate immune checkpoint limiting cGAS/STING-mediated antitumor immunity Cancer immunology research 2024-03-18 [PMID: 38489753] (Mouse)
• Pereira, M;Ramalho, T;Andrade, WA;Durso, DF;Souza, MC;Fitzgerald, KA;Golenbock, DT;Silverman, N;Gazzinelli, RT; The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection Cell reports 2024-02-15 [PMID: 38367238] (Mouse)
• Moreo, E;Jarit-Cabanillas, A;Robles-Vera, I;Uranga, S;Guerrero, C;Gómez, AB;Mata-Martínez, P;Minute, L;Araujo-Voces, M;Felgueres, MJ;Esteso, G;Uranga-Murillo, I;Arias, M;Pardo, J;Martín, C;Valés-Gómez, M;Del Fresno, C;Sancho, D;Aguiló, N; Intravenous administration of BCG in mice promotes natural killer and T cell-mediated antitumor immunity in the lung Nature communications 2023-10-04 [PMID: 37794033] (Mouse)
• Lin, HY;Cathomas, F;Li, L;Cuttoli, RD;Guevara, C;Bayrak, CS;Wang, Q;Gupta, S;Chan, KL;Shimo, Y;Parise, LF;Yuan, C;Aubry, AV;Chen, F;Wong, J;Morel, C;Huntley, GW;Zhang, B;Russo, SJ;Wang, J; Chemokine receptor 5 signaling in PFC mediates stress susceptibility in female mice bioRxiv : the preprint server for biology 2023-08-21 [PMID: 37662400] (Mouse)
• Nyariki, JN;Kimani, NM;Kibet, PS;Kinuthia, GK;Isaac, AO; Coenzyme Q10 exhibits anti-inflammatory and immune-modulatory thereby decelerating the occurrence of experimental cerebral malaria Molecular and biochemical parasitology 2023-06-27 [PMID: 37385350] (Mouse)
• Scheunemann, JF;Risch, F;Reichwald, JJ;Lenz, B;Neumann, AL;Garbe, S;Frohberger, SJ;Koschel, M;Ajendra, J;Rothe, M;Latz, E;Coch, C;Hartmann, G;Schumak, B;Hoerauf, A;H�bner, MP; Potential of Nucleic Acid Receptor Ligands to Improve Vaccination Efficacy against the Filarial Nematode Litomosoides sigmodontis Vaccines 2023-05-10 [PMID: 37243070] (Mouse)
• Aguilera-Herce, J;Panadero-Medianero, C;S�nchez-Romero, MA;Balbont�n, R;Bernal-Bayard, J;Ramos-Morales, F; Salmonella Type III Secretion Effector SrfJ: A Glucosylceramidase Affecting the Lipidome and the Transcriptome of Mammalian Host Cells International journal of molecular sciences 2023-05-07 [PMID: 37176110] (Mouse)
• S MacLauchla, P Kushwaha, A Tai, J Chen, C Manning, G Swarnkar, Y Abu-Amer, KA Fitzgerald, S Sharma, EM Gravallese STING-dependent interferon signatures restrict osteoclast differentiation and bone loss in mice Proceedings of the National Academy of Sciences of the United States of America, 2023-04-06;120(15):e2210409120. 2023-04-06 [PMID: 37023130] (Mouse)
• M Baran, C Feriotti, A McGinley, SR Carlile, Z Jiang, R Calderon-G, A Dumigan, J Sá-Pessoa, CE Sutton, J Kearney, RM McLoughlin, KHG Mills, KA Fitzgerald, JA Bengeochea, AG Bowie PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection Cell Reports, 2023-04-04;42(4):112341. 2023-04-04 [PMID: 37018072] (Mouse)
• D Levy, SN Abadchi, N Shababi, MR Ravari, NH Pirolli, C Bergeron, A Obiorah, F Mokhtari-E, S Gheshlaghi, JM Abraham, IM Smith, E Powsner, T Solomon, JW Harmon, SM Jay Induced pluripotent stem cell-derived extracellular vesicles promote wound repair in a diabetic mouse model via an anti-inflammatory immunomodulatory mechanism bioRxiv : the preprint server for biology, 2023-03-23;0(0):. 2023-03-23 [PMID: 36993554] (Mouse)
• Gina Córdoba-David, Jorge García-Giménez, Regiane Cardoso Castelo-Branco, Susana Carrasco, Pablo Cannata, Alberto Ortiz et al. Crosstalk between TBK1/IKK epsilon and the type I interferon pathway contributes to tubulointerstitial inflammation and kidney tubular injury Frontiers in Pharmacology 2022-09-23 [PMID: 36386242] (Mouse)
• D Zimmerli, CS Brambillas, F Talens, J Bhin, R Linstra, L Romanens, A Bhattachar, SEP Joosten, AM Da Silva, N Padrao, MD Wellenstei, K Kersten, M de Boo, M Roorda, L Henneman, R de Bruijn, S Annunziato, E van der Bu, AP Drenth, C Lutz, T Endres, M van de Ven, M Eilers, L Wessels, KE de Visser, W Zwart, RSN Fehrmann, MATM van Vugt, J Jonkers MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling Nature Communications, 2022-11-02;13(1):6579. 2022-11-02 [PMID: 36323660] (Mouse)
• J Lee, SY Ahn, CTT Le, DH Lee, J Jung, EJ Ko Protective and vaccine dose-sparing efficacy of Poly I:C-functionalized calcium phosphate nanoparticle adjuvants in inactivated influenza vaccination International immunopharmacology, 2022-09-14;112(0):109240. 2022-09-14 [PMID: 36115278] (Mouse)
• M Pereira, DF Durso, CE Bryant, EA Kurt-Jones, N Silverman, DT Golenbock, RT Gazzinelli The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways Cell Reports, 2022-08-16;40(7):111225. 2022-08-16 [PMID: 35977521] (Mouse)
• T Arsiwala, AS Vogt, AE Barton, V Manolova, F Funk, B Flühmann, MF Bachmann Kupffer Cells and Blood Monocytes Orchestrate the Clearance of Iron-Carbohydrate Nanoparticles from Serum International Journal of Molecular Sciences, 2022-02-28;23(5):. 2022-02-28 [PMID: 35269805] (Mouse)
• MC Morrison, E Gart, WV Duyvenvoor, J Snabel, MJ Nielsen, DJ Leeming, A Menke, R Kleemann Heat-Inactivated Akkermansia muciniphila Improves Gut Permeability but Does Not Prevent Development of Non-Alcoholic Steatohepatitis in Diet-Induced Obese Ldlr-/-.Leiden Mice International Journal of Molecular Sciences, 2022-02-19;23(4):. 2022-02-19 [PMID: 35216439] (Mouse)
• MH Ho, CH Yen, TH Hsieh, TJ Kao, JY Chiu, YH Chiang, BJ Hoffer, WC Chang, SY Chou CCL5 via GPX1 activation protects hippocampal memory function after mild traumatic brain injury Redox Biology, 2021-07-17;46(0):102067. 2021-07-17 [PMID: 34315111] (Mouse)
• P Reniewicz, A Kula, E Makuch, M Ochnik, T Lipi?ski, J Siednienko Ligase Pellino3 Regulates Macrophage Action and Survival in Response to VSV Infection in RIG-I-Dependent Path Oxidative Medicine and Cellular Longevity, 2021-07-01;2021(0):6668463. 2021-07-01 [PMID: 34306313] (Mouse)
• MTP de Oliveir, DS Coutinho, SS Guterres, AR Pohlmann, PMRE Silva, MA Martins, A Bernardi Resveratrol-Loaded Lipid-Core Nanocapsules Modulate Acute Lung Inflammation and Oxidative Imbalance Induced by LPS in Mice Pharmaceutics, 2021-05-10;13(5):. 2021-05-10 [PMID: 34068619] (Mouse)
• L Ntari, C Nikolaou, K Kranidioti, D Papadopoul, E Christodou, P Chouvardas, F Meier, C Geka, MC Denis, N Karagianni, G Kollias Combination of subtherapeutic anti-TNF dose with dasatinib restores clinical and molecular arthritogenic profiles better than standard anti-TNF treatment Journal of Translational Medicine, 2021-04-23;19(1):165. 2021-04-23 [PMID: 33892739] (Mouse)
• Chunmei Ma, Sheng Li, Yingchao Hu, Yan Ma, Yuqing Wu, Chunyan Wu et al. AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis Journal of Experimental Medicine 2021-05-03 [PMID: 33710283] (Mouse)
• E Mai, CM Percopo, AR Limkar, AC Sek, M Ma, HF Rosenberg Respiratory Epithelial Cells Respond to Lactobacillus plantarum but Provide No Cross-Protection against Virus-Induced Inflammation Viruses, 2020-12-22;13(1):. 2020-12-22 [PMID: 33374950] (Mouse)
• D Bonhomme, I Santecchia, F Vernel-Pau, M Caroff, P Germon, G Murray, B Adler, IG Boneca, C Werts Leptospiral LPS escapes mouse TLR4 internalization and TRIF?associated antimicrobial responses through O antigen and associated lipoproteins PLoS Pathog., 2020-08-13;16(8):e1008639. 2020-08-13 [PMID: 32790743] (Mouse)
• MZ Noman, S Parpal, K Van Moer, M Xiao, Y Yu, J Viklund, A De Milito, M Hasmim, M Andersson, RK Amaravadi, J Martinsson, G Berchem, B Janji Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti-PD-1/PD-L1 immunotherapy Sci Adv, 2020-04-29;6(18):eaax7881. 2020-04-29 [PMID: 32494661] (Mouse)
• S Ribes, C Arcilla, M Ott, S Schütze, UK Hanisch, S Nessler, R Nau Pre-treatment with the viral Toll-like receptor 3 agonist poly(I:C) modulates innate immunity and protects neutropenic mice infected intracerebrally with Escherichia coli J Neuroinflammation, 2020-01-17;17(1):24. 2020-01-17 [PMID: 31952519] (Mouse)
• A Gebhardt, V Bergant, D Schnepf, M Moser, A Meiler, D Togbe, C Mackowiak, LS Reinert, SR Paludan, B Ryffel, A Stukalov, P Staeheli, A Pichlmair The alternative cap-binding complex is required for antiviral defense in vivo PLoS Pathog., 2019-12-19;15(12):e1008155. 2019-12-19 [PMID: 31856218] (Mouse)
• L Yue, M Yan, ML Tremblay, TJ Lin, H Li, T Yang, X Song, T Xie, Z Xie PTP1B negatively regulates nitric oxide-mediated Pseudomonas aeruginosa killing by neutrophils PLoS ONE, 2019-09-18;14(9):e0222753. 2019-09-18 [PMID: 31532798] (Mouse)
• VN Camargos, G Foureaux, DC Medeiros, VT da Silveir, CM Queiroz-Ju, ALB Matosinhos, AFA Figueiredo, CDF Sousa, TP Moreira, VF Queiroz, ACF Dias, KTO Santana, I Passos, ALCV Real, LC Silva, FAG Mourão, NT Wnuk, MAP Oliveira, S Macari, T Silva, GP Garlet, JA Jackman, FM Soriani, MFD Moraes, EMAM Mendes, FM Ribeiro, GMJ Costa, AL Teixeira, NJ Cho, ACP Oliveira, MM Teixeira, VV Costa, DG Souza In-depth characterization of congenital Zika syndrome in immunocompetent mice: Antibody-dependent enhancement and an antiviral peptide therapy EBioMedicine, 2019-05-23;0(0):. 2019-05-23 [PMID: 31130472] (Mouse)
• I Santecchia, F Vernel-Pau, O Rasid, J Quintin, M Gomes-Sole, IG Boneca, C Werts Innate immune memory through TLR2 and NOD2 contributes to the control of Leptospira interrogans infection PLoS Pathog., 2019-05-20;15(5):e1007811. 2019-05-20 [PMID: 31107928] (Mouse)
• M William, LP Leroux, V Chaparro, TE Graber, T Alain, M Jaramillo Translational repression of Ccl5 and Cxcl10 by 4E-BP1 and 4E-BP2 restrains the ability of mouse macrophages to induce migration of activated T�cells Eur. J. Immunol., 2019-05-06;0(0):. 2019-05-06 [PMID: 31032899] (Mouse)
• V Ciancarell, L Lembo-Fazi, I Paciello, AK Bruno, S Jaillon, S Berardi, M Barbagallo, S Meron-Suda, D Cohen, A Molinaro, G Rossi, C Garlanda, ML Bernardini Role of a fluid-phase PRR in fighting an intracellular pathogen: PTX3 in Shigella infection PLoS Pathog., 2018-12-07;14(12):e1007469. 2018-12-07 [PMID: 30532257] (Mouse)
• GM Wiedemann, C Aithal, A Kraechan, C Heise, BL Cadilha, J Zhang, P Duewell, R Ballotti, S Endres, C Bertolotto, S Kobold Microphthalmia-Associated Transcription Factor (MITF) Regulates Immune Cell Migration into Melanoma Transl Oncol, 2018-11-28;12(2):350-360. 2018-11-28 [PMID: 30502589] (Mouse)
• XF Zhang, Y Yang, XY Yang, Q Tong MiR-188-3p upregulation results in the inhibition of macrophage proinflammatory activities and atherosclerosis in ApoE-deficient mice Thromb. Res., 2018-09-05;171(0):55-61. 2018-09-05 [PMID: 30253270] (Mouse)
• A Singanayag, N Glanville, JL Girkin, YM Ching, A Marcellini, JD Porter, M Toussaint, RP Walton, LJ Finney, J Aniscenko, J Zhu, MB Trujillo-T, MA Calderazzo, C Grainge, SL Loo, PC Veerati, PS Pathinayak, KS Nichol, AT Reid, PL James, R Solari, PAB Wark, DA Knight, MF Moffatt, WO Cookson, MR Edwards, P Mallia, NW Bartlett, SL Johnston Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations Nat Commun, 2018-06-08;9(1):2229. 2018-06-08 [PMID: 29884817] (Mouse)
• Angelica Martins Batista, Lucia Elena Alvarado-, Silvia Marinho Alves, Gloria Melo, Isabela Resende Pereira, Leonardo Alexandre de Sou Ruivo, Andrea Alice Da Silva, Daniel Gibaldi, Thayse Do E S Protásio Da Silva, Virginia Maria Barros De Lorena, Adriene Siqueira De Melo, Ana Karine De Araújo, Michelle Da Silva Barros, Vláudia Maria Assis Costa, Cynthia C Cardoso, Antonio G Pacheco, Cristina Carrazzon, Wilson Oliveira, Milton Ozório Moraes, Joseli Lannes-Vi Genetic Polymorphism at CCL5 Is Associated With Protection in Chagas' Heart Disease: Antagonistic Participation of CCR1+ and CCR5+ Cells in Chronic Chagasic Cardiomyopathy. Frontiers in Immunology, 2018-04-11;0(0):1664-3224. 2018-04-11 [PMID: 29696014] (Mouse)
• M Ding, A Cavallin, NO Hermansson, P Berntsson, L Jinton, S Rodrigo Bl Comparing Flow Cytometry QBeads PlexScreen Assays with Other Immunoassays for Determining Multiple Analytes SLAS Discov, 2018-04-24;0(0):2472555218771. 2018-04-24 [PMID: 29689168] (Mouse)
• M Rami, R Guillamat-, P Rinne, M Salvermose, L Ring, M Bianchini, X Blanchet, RTA Megens, Y Döring, B Walzog, O Soehnlein, C Weber, A Faussner, S Steffens Chronic Intake of the Selective Serotonin Reuptake Inhibitor Fluoxetine Enhances Atherosclerosis Arterioscler. Thromb. Vasc. Biol., 2018-03-22;0(0):. 2018-03-22 [PMID: 29567680] (Mouse)
• D Fang, K Cui, G Hu, RK Gurram, C Zhong, AJ Oler, R Yagi, M Zhao, S Sharma, P Liu, B Sun, K Zhao, J Zhu Bcl11b, a novel GATA3-interacting protein, suppresses Th1 while limiting Th2 cell differentiation J. Exp. Med., 2018-03-07;0(0):. 2018-03-07 [PMID: 29514917] (Mouse)
• S Paetau, T Rolova, L Ning, CG Gahmberg Neuronal ICAM-5 Inhibits Microglia Adhesion and Phagocytosis and Promotes an Anti-inflammatory Response in LPS Stimulated Microglia Front Mol Neurosci, 2017-12-22;10(0):431. 2017-12-22 [PMID: 29311819] (Mouse)
• EE Hornick, B Banoth, AM Miller, ZR Zacharias, N Jain, ME Wilson, KN Gibson-Cor, KL Legge, GA Bishop, FS Sutterwala, SL Cassel Nlrp12 Mediates Adverse Neutrophil Recruitment during Influenza Virus Infection J. Immunol., 2017-12-27;0(0):. 2017-12-27 [PMID: 29282312] (Mouse)
• M Coorens, VAF Schneider, AM de Groot, A van Dijk, M Meijerink, JM Wells, MR Scheenstra, EJA Veldhuizen, HP Haagsman Cathelicidins Inhibit Escherichia coli-Induced TLR2 and TLR4 Activation in a Viability-Dependent Manner J. Immunol., 2017-07-14;0(0):. 2017-07-14 [PMID: 28710255] (Mouse)
• FD Lorenzo, A Palmigiano, I Paciello, M Pallach, D Garozzo, ML Bernardini, V Cono, MM Yakimov, A Molinaro, A Silipo The Deep-Sea Polyextremophile Halobacteroides lacunaris TB21 Rough-Type LPS: Structure and Inhibitory Activity towards Toxic LPS Mar Drugs, 2017-06-27;15(7):. 2017-06-27 [PMID: 28653982] (Mouse)
• DW Wojkowska, P Szpakowski, A Glabinski Interleukin 17A Promotes Lymphocytes Adhesion and Induces CCL2 and CXCL1 Release from Brain Endothelial Cells Int J Mol Sci, 2017-05-08;18(5):. 2017-05-08 [PMID: 28481289] (Mouse)
• CT Molloy, JS Andonian, HM Seltzer, MC Procario, ME Watson, JB Weinberg Contributions of CD8 T cells to the pathogenesis of mouse adenovirus type 1 respiratory infection Virology, 2017-04-11;507(0):64-74. 2017-04-11 [PMID: 28410483] (Mouse)
• M Losada-Bar, A Umaña-Pére, S Cuervo-Esc, LR Berbert, R Porrozzi, FN Morgado, DA Mendes-da-, W Savino, M Sánchez-Gó, P Cuervo Protein malnutrition promotes dysregulation of molecules involved in T cell migration in the thymus of mice infected with Leishmania infantum Sci Rep, 2017-04-11;7(0):45991. 2017-04-11 [PMID: 28397794] (Mouse)
• LT Hsieh, MV Nastase, H Roedig, J Zeng-Brouw, C Poluzzi, S Schwalm, C Fork, C Tredup, RP Brandes, M Wygrecka, A Huwiler, J Pfeilschif, L Schaefer Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants Int J Mol Sci, 2017-03-09;18(3):. 2017-03-09 [PMID: 28282921] (Human)
• Y Murakami, R Fukui, Y Motoi, T Shibata, SI Saitoh, R Sato, K Miyake The protective effect of the anti-Toll-like receptor 9 antibody against acute cytokine storm caused by immunostimulatory DNA Sci Rep, 2017-03-07;7(0):44042. 2017-03-07 [PMID: 28266597] (Mouse)
• YT Chu, SW Wan, YC Chang, CK Lee, BA Wu-Hsieh, R Anderson, YS Lin Antibodies against nonstructural protein 1 protect mice from dengue virus-induced mast cell activation Lab. Invest, 2017-02-27;0(0):. 2017-02-27 [PMID: 28240747] (Mouse)
• T Hartwig, A Montinaro, S von Karste, A Sevko, S Surinova, A Chakravart, L Taraborrel, P Draber, E Lafont, F Arce Varga, MA El-Bahrawy, SA Quezada, H Walczak The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2 Mol. Cell, 2017-02-16;65(4):730-742.e5. 2017-02-16 [PMID: 28212753] (Mouse)
• SB Fleming, C McCaughan, Z Lateef, A Dunn, LM Wise, NC Real, AA Mercer Deletion of the Chemokine Binding Protein Gene from the Parapoxvirus Orf Virus Reduces Virulence and Pathogenesis in Sheep Front Microbiol, 2017-01-24;8(0):46. 2017-01-24 [PMID: 28174562] (Mouse)
• M Coorens, MR Scheenstra, EJ Veldhuizen, HP Haagsman Interspecies cathelicidin comparison reveals divergence in antimicrobial activity, TLR modulation, chemokine induction and regulation of phagocytosis Sci Rep, 2017-01-19;7(0):40874. 2017-01-19 [PMID: 28102367] (Mouse)
• Andrey Lozhkin NADPH oxidase 4 regulates vascular inflammation in aging and atherosclerosis J. Mol. Cell. Cardiol, 2016-12-14;0(0):. 2016-12-14 [PMID: 27986445] (Mouse)
• Nigel Mackman Protease-Activated Receptor 1 Enhances Poly I:C Induction of the Antiviral Response in Macrophages and Mice J Innate Immun, 2016-11-08;0(0):. 2016-11-08 [PMID: 27820939] (Mouse)
• SW Huang, C Walker, J Pennock, K Else, W Muller, MJ Daniels, C Pellegrini, D Brough, G Lopez-Cast, SM Cruickshan P2X7 receptor-dependent tuning of gut epithelial responses to infection Immunol. Cell Biol, 2016-08-25;95(2):178-188. 2016-08-25 [PMID: 27559003] (Mouse)
• Brown A, Murphy A, Lalor S, Leech J, O'Keeffe K, Mac Aogain M, O'Halloran D, Lacey K, Tavakol M, Hearnden C, Fitzgerald-Hughes D, Humphreys H, Fennell J, van Wamel W, Foster T, Geoghegan J, Lavelle E, Rogers T, McLoughlin R Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection. PLoS Pathog, 2015-11-05;11(11):e1005226. 2015-11-05 [PMID: 26539822] (Mouse)
• Todd D, Gulledge T, Britton E, Oberhofer M, Leyte-Lugo M, Moody A, Shymanovich T, Grubbs L, Juzumaite M, Graf T, Oberlies N, Faeth S, Laster S, Cech N Ethanolic Echinacea purpurea Extracts Contain a Mixture of Cytokine-Suppressive and Cytokine-Inducing Compounds, Including Some That Originate from Endophytic Bacteria. PLoS ONE, 2015-05-01;10(5):e0124276. 2015-05-01 [PMID: 25933416] (Mouse)
• Sottnik J, Dai J, Zhang H, Campbell B, Keller E Tumor-induced pressure in the bone microenvironment causes osteocytes to promote the growth of prostate cancer bone metastases. Cancer Res, 2015-04-08;75(11):2151-8. 2015-04-08 [PMID: 25855383] (Mouse)
• Verheijden K, Willemsen L, Braber S, Leusink-Muis T, Delsing D, Garssen J, Kraneveld A, Folkerts G Dietary galacto-oligosaccharides prevent airway eosinophilia and hyperresponsiveness in a murine house dust mite-induced asthma model. Respir Res, 2015-02-07;16(0):17. 2015-02-07 [PMID: 25849971] (Mouse)
• Lacerda-Queiroz N, Brant F, Rodrigues D, Vago J, Rachid M, Sousa L, Teixeira M, Teixeira A Phosphatidylinositol 3-Kinase gamma is required for the development of experimental cerebral malaria. PLoS ONE, 2015-03-16;10(3):e0119633. 2015-03-16 [PMID: 25775137] (Mouse)
• Kearney C, Cullen S, Tynan G, Henry C, Clancy D, Lavelle E, Martin S Necroptosis suppresses inflammation via termination of TNF- or LPS-induced cytokine and chemokine production. Cell Death Differ, 2015-01-23;22(8):1313-27. 2015-01-23 [PMID: 25613374] (Mouse)
• Barra , Nicole G, Palanivel , Rengasam, Denou , Emmanuel, Chew , Marianne, Gillgrass , Amy, Walker , Tina D, Kong , Josh, Richards , Carl D, Jordana , Manel, Collins , Stephen, Trigatti , Bernardo, Holloway , Alison C, Raha , Sandeep, Steinberg , Gregory, Ashkar , Ali A Interleukin-15 modulates adipose tissue by altering mitochondrial mass and activity. PLoS ONE, 2014-12-17;9(12):e114799. 2014-12-17 [PMID: 25517731] (Mouse)
• Lennard Richard M, Sato S, Suzuki E, Williams S, Nowling T, Zhang X The Fli-1 transcription factor regulates the expression of CCL5/RANTES. J Immunol, 2014-08-06;193(6):2661-8. 2014-08-06 [PMID: 25098295] (Mouse)
• Walsh K, Teijaro J, Brock L, Fremgen D, Collins P, Rosen H, Oldstone M Animal model of respiratory syncytial virus: CD8+ T cells cause a cytokine storm that is chemically tractable by sphingosine-1-phosphate 1 receptor agonist therapy. J Virol, 2014-03-26;88(11):6281-93. 2014-03-26 [PMID: 24672024] (Mouse)
• Teijaro J, Walsh K, Rice S, Rosen H, Oldstone M Mapping the innate signaling cascade essential for cytokine storm during influenza virus infection. Proc Natl Acad Sci U S A, 2014-02-26;111(10):3799-804. 2014-02-26 [PMID: 24572573] (Mouse)
• Menezes-Garcia Z, Oliveira M, Lima R, Soriani F, Cisalpino D, Botion L, Teixeira M, Souza D, Ferreira A Lack of platelet-activating factor receptor protects mice against diet-induced adipose inflammation and insulin-resistance despite fat pad expansion. Obesity (Silver Spring), 2013-12-14;22(3):663-72. 2013-12-14 [PMID: 24339378] (Mouse)
• Paulissen G, El Hour M, Rocks N, Gueders M, Bureau F, Foidart J, Lopez-Otin C, Noel A, Cataldo D Control of allergen-induced inflammation and hyperresponsiveness by the metalloproteinase ADAMTS-12. J Immunol, 2012-09-07;189(8):4135-43. 2012-09-07 [PMID: 22962682] (Mouse)
• Suzukawa M, Morita H, Nambu A, Arae K, Shimura E, Shibui A, Yamaguchi S, Suzukawa K, Nakanishi W, Oboki K, Kajiwara N, Ohno T, Ishii A, Korner H, Cua D, Suto H, Yoshimoto T, Iwakura Y, Yamasoba T, Ohta K, Sudo K, Saito H, Okumura K, Broide D, Matsumoto K, Nakae S Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, Is crucial for murine asthma. J Immunol, 2012-08-31;189(7):3641-52. 2012-08-31 [PMID: 22942422] (Mouse)
• Singh PP, Smith VL, Karakousis PC, Schorey JS Exosomes isolated from mycobacteria-infected mice or cultured macrophages can recruit and activate immune cells in vitro and in vivo. J. Immunol., 2012-06-20;189(2):777-85. 2012-06-20 [PMID: 22723519] (Mouse)
• Chuquimia OD, Petursdottir DH, Rahman MJ, Hartl K, Singh M, Fernandez C The role of alveolar epithelial cells in initiating and shaping pulmonary immune responses: communication between innate and adaptive immune systems. PLoS ONE, 2012-02-29;7(2):e32125. 2012-02-29 [PMID: 22393384] (Mouse)
• Wolf A, Beuerlein K, Eckart C, Weiser H, Dickkopf B, Muller H, Sakurai H, Kracht M Identification and functional characterization of novel phosphorylation sites in TAK1-binding protein (TAB) 1. PLoS ONE, 2011-12-22;6(12):e29256. 2011-12-22 [PMID: 22216226] (Mouse)
• Veliz Rodriguez T, Moalli F, Polentarutti N, Paroni M, Bonavita E, Anselmo A, Nebuloni M, Mantero S, Jaillon S, Bragonzi A, Mantovani A, Riva F, Garlanda C Role of Toll interleukin-1 receptor (IL-1R) 8, a negative regulator of IL-1R/Toll-like receptor signaling, in resistance to acute Pseudomonas aeruginosa lung infection. Infect. Immun., 2011-10-24;80(1):100-9. 2011-10-24 [PMID: 22025515] (Mouse)
• Teijaro JR, Walsh KB, Cahalan S, Fremgen DM, Roberts E, Scott F, Martinborough E, Peach R, Oldstone MB, Rosen H Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection. Cell, 2011-09-16;146(6):980-91. 2011-09-16 [PMID: 21925319] (Mouse)
• Walsh KB, Teijaro JR, Wilker PR Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus. Proc. Natl. Acad. Sci. U.S.A., 2011-06-29;108(29):12018-23. 2011-06-29 [PMID: 21715659] (Mouse)
• Hughes DJ, Kipar A, Leeming GH, Bennett E, Howarth D, Cummerson JA, Papoula-Pereira R, Flanagan BF, Sample JT, Stewart JP Chemokine binding protein M3 of murine gammaherpesvirus 68 modulates the host response to infection in a natural host. PLoS Pathog., 2011-03-17;7(3):e1001321. 2011-03-17 [PMID: 21445235] (Mouse)
• van Neerven S, Regen T, Wolf D, Nemes A, Johann S, Beyer C, Hanisch UK, Mey J Inflammatory chemokine release of astrocytes in vitro is reduced by all-trans retinoic acid. J. Neurochem., 2010-06-16;114(5):1511-26. 2010-06-16 [PMID: 20557428] (Mouse)
• Wan H, Coppens JM, van Helden-Meeuwsen CG, Leenen PJ, Van Rooijen N, Khan NA, Kiekens RC, Benner R, Versnel MA Chorionic gonadotropin alleviates thioglycollate-induced peritonitis by affecting macrophage function. J. Leukoc. Biol., 2009-05-04;86(2):361-70. 2009-05-04 [PMID: 19414540] (Mouse)
• Lin CF, Tsai CC, Huang WC, Wang CY, Tseng HC, Wang Y, Kai JI, Wang SW, Cheng YL IFN-gamma synergizes with LPS to induce nitric oxide biosynthesis through glycogen synthase kinase-3-inhibited IL-10. J. Cell. Biochem., 2008-10-15;105(3):746-55. 2008-10-15 [PMID: 18655171] (Mouse)
• Chou SY, Weng JY, Lai HL, Liao F, Sun SH, Tu PH, Dickson DW, Chern Y Expanded-polyglutamine huntingtin protein suppresses the secretion and production of a chemokine (CCL5/RANTES) by astrocytes. J. Neurosci., 2008-03-26;28(13):3277-90. 2008-03-26 [PMID: 18367595] (Mouse)
• Macedo GC, Magnani DM, Carvalho NB, Bruna-Romero O, Gazzinelli RT, Oliveira SC Central role of MyD88-dependent dendritic cell maturation and proinflammatory cytokine production to control Brucella abortus infection. J. Immunol., 2008-01-15;180(2):1080-7. 2008-01-15 [PMID: 18178848] (Mouse)
• Arias MA, Jaramillo G, Lopez YP, Mejia N, Mejia C, Pantoja AE, Shattock RJ, Garcia LF, Griffin GE Mycobacterium tuberculosis antigens specifically modulate CCR2 and MCP-1/CCL2 on lymphoid cells from human pulmonary hilar lymph nodes. J. Immunol., 2007-12-15;179(12):8381-91. 2007-12-15 [PMID: 18056384] (Human)
• Schell JB, Crane CA, Smith MF, Roberts MR Differential ex vivo nitric oxide production by acutely isolated neonatal and adult microglia. J. Neuroimmunol., 2007-08-15;189(1):75-87. 2007-08-15 [PMID: 17698208] (Mouse)
• Levy BD, Lukacs NW, Berlin AA, Schmidt B, Guilford WJ, Serhan CN, Parkinson JF Lipoxin A4 stable analogs reduce allergic airway responses via mechanisms distinct from CysLT1 receptor antagonism. FASEB J., 2007-07-11;21(14):3877-84. 2007-07-11 [PMID: 17625069] (Mouse)
• Hegde A, Zhang H, Moochhala SM, Bhatia M Neurokinin-1 receptor antagonist treatment protects mice against lung injury in polymicrobial sepsis. J. Leukoc. Biol., 2007-06-12;82(3):678-85. 2007-06-12 [PMID: 17565047] (Mouse)
• Schnyder-Candrian S, Togbe D, Couillin I, Mercier I, Brombacher F, Quesniaux V, Fossiez F, Ryffel B, Schnyder B Interleukin-17 is a negative regulator of established allergic asthma. J. Exp. Med., 2006-11-13;203(12):2715-25. 2006-11-13 [PMID: 17101734] (Mouse)
• Nakamichi K, Saiki M, Kitani H, Kuboyama Y, Morimoto K, Takayama-Ito M, Kurane I Suppressive effect of simvastatin on interferon-beta-induced expression of CC chemokine ligand 5 in microglia. Neurosci. Lett., 2006-09-15;407(3):205-10. 2006-09-15 [PMID: 16978784] (Mouse)
• Tengvall S, Lundqvist A, Eisenberg RJ, Cohen GH, Harandi AM Mucosal administration of CpG oligodeoxynucleotide elicits strong CC and CXC chemokine responses in the vagina and serves as a potent Th1-tilting adjuvant for recombinant gD2 protein vaccination against genital herpes. J. Virol., 2006-06-01;80(11):5283-91. 2006-06-01 [PMID: 16699008] (Mouse)
• Okamatsu Y, Battaglino R, Spate U, Stashenko P MIP-1 gamma promotes receptor-activator-of-NF-kappa-B-ligand-induced osteoclast formation and survival. J. Immunol., 2004-08-01;173(3):2084-90. 2004-08-01 [PMID: 15265944] (Mouse)
• Punturieri A, Alviani RS, Polak T, Copper P, Sonstein J, Curtis JL Specific engagement of TLR4 or TLR3 does not lead to IFN-beta-mediated innate signal amplification and STAT1 phosphorylation in resident murine alveolar macrophages. J. Immunol., 2004-07-15;173(2):1033-42. 2004-07-15 [PMID: 15240691] (Mouse)
• Raghavan S, Nystrom J, Fredriksson M, Holmgren J, Harandi AM Orally administered CpG oligodeoxynucleotide induces production of CXC and CC chemokines in the gastric mucosa and suppresses bacterial colonization in a mouse model of Helicobacter pylori infection. Infect. Immun., 2003-12-01;71(12):7014-22. 2003-12-01 [PMID: 14638791] (Mouse)

FAQs for CCL5/RANTES (DY478). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: Ccl5