MOG Antibody

Western Blot: MOG Antibody [NB300-948] - (0.03ug/ml) staining of Human Amygdala lysate (35ug protein in RIPA buffer). Detected by chemiluminescence.

• Reactivity: Hu, Po, Mu, Rt, Bv
• Applications: WB, ELISA
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

MOG Antibody Summary

• Description: Novus Biologicals Goat MOG Antibody (NB300-948) is a polyclonal antibody validated for use in WB and ELISA. Anti-MOG Antibody: Cited in 3 publications. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Peptide with sequence C-AGQFLEELRNPF corresponding to C-Terminus according to NP_996532.2, NP_996535.2, NP_001008229.1.
• Marker: Oligodendrocyte Marker
• Specificity: This antibody is expected to recognise NP_996532.2 (isf a1), NP_996535.2 (isf a2) and NP_001008229.1 (isf a3)
• Predicted Species: Mouse (100%), Rat (100%), Bovine (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: MOG
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:16000
  • Western Blot 0.03 - 1 ug/ml
• Application Notes: Western Blot: Approx 26kDa band observed in Human Brain lysates (calculated MW of 25.4kDa according to NP_001008229.1). Recommended concentration: 0.03-0.1ug/ml. Primary incubation was for 1 hour.

Reactivity Notes

Use in Porcine reported in scientific literature (PMID:35027884) .

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for MOG Antibody

• MGC26137
• MOG Ig-AluB
• MOG
• MOGIG2
• myelin oligodendrocyte glycoprotein
• myelin-oligodendrocyte glycoprotein

Background

The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for MOG Antibody (NB300-948)(3)

Publications using NB300-948

• Ahmed S, Travis S, DIaz-Bahamonde F et al. Early Influences of Microbiota on White Matter Development in Germ-Free Piglets Frontiers in Cellular Neuroscience 2021-12-27 [PMID: 35027884] (WB, Porcine)
• Wang Z, Baharani A, Wei Z et al. Low Field Magnetic Stimulation Promotes Myelin Repair and Cognitive Recovery in Chronic Cuprizone Mouse Model Clinical and experimental pharmacology & physiology 2021-02-26 [PMID: 33638234]
• Zai G, King N, Wigg K et al. Genetic study of the myelin oligodendrocyte glycoprotein (MOG) gene in schizophrenia. Genes Brain Behav 2005-02-01 [PMID: 15660663]

Bioinformatics

• Gene Symbol: MOG
• Entrez:
  • 4340(Human)
  • 17441(Mouse)
  • 24558(Rat)
• Uniprot:
  • NP_002424()