MNX1/HLXB9 Antibody

Product Discontinued

MNX1/HLXB9 Antibody Summary

• Immunogen: A 20 amino acid synthetic HB9 peptide (HAPADRLRAESPSPPRLLAAHC-NH2), conjugated to Blue Carrier Protein.
• Specificity: Specific for HB9. Confirmed by Immunohistochemical analysis of Normal Term and First Trimester human Placenta as well as western blot analysis of mouse Neuroblastoma and Spinal Cord cells (NSC-34).
• Clonality: Polyclonal
• Host: Sheep
• Gene: MNX1
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Western Blot 1:100-1:2000
• Control:

  MNX1/HLXB9 Overexpression Lysate

Reactivity Notes

This antibody is reactive against Human and Mouse. Not yet tested in other species.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Whole antisera
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Unpurified
• Reconstitution Instructions: Reconstitute with 0.02 ml distilled water.

Alternate Names for MNX1/HLXB9 Antibody

• HB9
• HLXB9motor neuron and pancreas homeobox protein 1
• homeobox HB9
• HOXHB9Homeobox protein HB9
• motor neuron and pancreas homeobox 1
• SCRA1homeo box HB9

Background

The homeobox gene Hb9/Hlxb9, is expressed selectively by motor neurons (MNs) in the developing vertebrate CNS. Hb9, which encodes a factor central to MN development regulates neuronal fate by restricting expression of Lim3 and Even-skipped (Eve), two homeodomain (HD) proteins required for development of distinct neuronal classes. In the vertebrate CNS, HB9/MNR2 transcription factors are specifically expressed in all somatic motoneurons and are necessary to distinguish motoneurons from interneurons. Hb9 is also a transcription factor expressed in lymphoid and pancreatic tissue. In humans, HB9 mutation causes an autosomal dominant form of sacral agenesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MNX1
• Entrez:
  • 3110(Human)
  • 15285(Mouse)
• Uniprot:
  • P50219(Human)