MNX1/HLXB9 Products

Description

The homeobox gene Hb9/Hlxb9, is expressed selectively by motor neurons (MNs) in the developing vertebrate CNS. Hb9, which encodes a factor central to MN development regulates neuronal fate by restricting expression of Lim3 and Even-skipped (Eve), two homeodomain (HD) proteins required for development of distinct neuronal classes. In the vertebrate CNS, HB9/MNR2 transcription factors are specifically expressed in all somatic motoneurons and are necessary to distinguish motoneurons from interneurons. Hb9 is also a transcription factor expressed in lymphoid and pancreatic tissue. In humans, HB9 mutation causes an autosomal dominant form of sacral agenesis.

Bioinformatics

Entrez	15285 Mouse 3110 Human
Uniprot	NM_005515 Human NP_005506.3 Human P50219 Human
Product By Gene ID	3110
Alternate Names	HB9 HLXB9motor neuron and pancreas homeobox protein 1 homeobox HB9 HOXHB9Homeobox protein HB9 motor neuron and pancreas homeobox 1 SCRA1homeo box HB9