Species: Hu, Mu, Rt
Applications: WB, ELISA, Flow, ICC/IF, IP, KD
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, KO
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Description
MFN1 (Mitofusin-1) is a nuclear encoded mitochondrial membrane protein that mediates mitochondrial fusion and morphology in mammalian cells. MFN1 and MFN2 are homologs of the Drosophila protein Fuzzy Onion (Fzo) that interact with each other to facilitate mitochondrial targeting. MFN1 is ubiquitously expressed,with slightly higher leves detectedl in kidney and heart. MFN2 may be overexpressed in some tumors, such as lung cancers.
Mitochondrial fusion occurs in many cell types and is a fundamental component of mitochondria morphology, which is balanced between fusion and fission. Mitochondrial dysfunction is a major cause of neuronal death in degenerative disorders, such as Parkinson's disease, and can be triggered by an imbalance in the dynamic equilibrium between mitochondrial fission and fusion.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
|
| Product By Gene ID |
55669 |
| Alternate Names |
- DKFZp762F247
- EC 3.6.5
- EC 3.6.5.-
- FLJ20693
- Fzo homolog
- hfzo1
- hfzo2
- MGC41806
- mitochondrial transmembrane GTPase Fzo-1
- mitochondrial transmembrane GTPase FZO-2
- mitofusin 1
- mitofusin-1
- putative transmembrane GTPase
- Transmembrane GTPase MFN1
|
