Mitofusin 1 Antibody (11E9-1H12) [FITC]

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Product Details

Summary
Reactivity Mu, RtSpecies Glossary
Applications ICC/IF, IHC, IHC-P
Clone
11E9-1H12
Clonality
Monoclonal
Host
Mouse
Conjugate
FITC

Mitofusin 1 Antibody (11E9-1H12) [FITC] Summary

Immunogen
Mouse Mitofusin-1 [Swiss-Prot# Q811U4]
Localization
Mitochondrion outer membrane; Multi-pass membrane protein
Marker
Mitochondrial Fusion Marker
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Gene
MFN1
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
This Mitofusin-1 (11E9-1H12) antibody is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry on paraffin-embedded sections and Western blot, where a band can be seen at ~80 kDa.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
80 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Mouse. Rat reactivity reported in scientific literature (PMID: 23658809).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Mitofusin 1 Antibody (11E9-1H12) [FITC]

  • DKFZp762F247
  • EC 3.6.5
  • EC 3.6.5.-
  • FLJ20693
  • Fzo homolog
  • hfzo1
  • hfzo2
  • MFN1
  • MGC41806
  • mitochondrial transmembrane GTPase Fzo-1
  • mitochondrial transmembrane GTPase FZO-2
  • Mitofusin 1
  • mitofusin-1
  • putative transmembrane GTPase
  • Transmembrane GTPase MFN1

Background

Mitochondria are dynamic organelles that continuously divide and fuse, and their dynamics/distribution is critical for their role in bioenergetics and cell survival. Mitochondrial fusion process is mediated by mitofusin 1 (MFN1) and mitofusin 2 (MFN2) proteins in the outer membrane as well as OPA1 in the inner mitochondrial membrane. MFN1 is an essential transmembrane GTPase critical to mitochondrial fusion; acts independently of the cytoskeleton, and its overexpression induces formation of mitochondrial networks. MFN1 forms homo-/-heteromultimers (with MFN2), and the multimerization has been proposed to be essential for mitochondrion fusion. MFN1 interacts with VAT1 and is ubiquitinated by MARCH5. A mutation in the GTPase domain disrupts the mitochondrial fusion activity of MFN1/MFN2 and loss of MFN1/2 leads to mitochondrial dysfunction mediated embryonic lethality in mice. MFN proteins have been reported to regulate mitochondrial membrane potential, while silencing of MFN1/2 resulte in mitochondrial fragmentation and increased apoptotic sensitivity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Biotin Labeled NBP1-71775B
DyLight 350 Labeled NBP1-71775UV
DyLight 405 Labeled NBP1-71775V
DyLight 488 Labeled NBP1-71775G
DyLight 550 Labeled NBP1-71775R
DyLight 650 Labeled NBP1-71775C
DyLight 680 Labeled NBP1-71775FR
DyLight 755 Labeled NBP1-71775IR
HRP Labeled NBP1-71775H

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Bioinformatics

Gene Symbol MFN1
Entrez