Mitofusin 1 Antibody (11E9-1H12) [DyLight 550]

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Product Details

Summary
Reactivity Mu, RtSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
Clone
11E9-1H12
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 550

Mitofusin 1 Antibody (11E9-1H12) [DyLight 550] Summary

Immunogen
Mouse Mitofusin-1 [Swiss-Prot# Q811U4]
Localization
Mitochondrion outer membrane; Multi-pass membrane protein
Marker
Mitochondrial Fusion Marker
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Gene
MFN1
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Western Blot
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
This Mitofusin-1 (11E9-1H12) antibody is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry on paraffin-embedded sections and Western blot, where a band can be seen at ~80 kDa.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
80 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Mouse. Rat reactivity reported in scientific literature (PMID: 23658809).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Mitofusin 1 Antibody (11E9-1H12) [DyLight 550]

  • DKFZp762F247
  • EC 3.6.5
  • EC 3.6.5.-
  • FLJ20693
  • Fzo homolog
  • hfzo1
  • hfzo2
  • MFN1
  • MGC41806
  • mitochondrial transmembrane GTPase Fzo-1
  • mitochondrial transmembrane GTPase FZO-2
  • Mitofusin 1
  • mitofusin-1
  • putative transmembrane GTPase
  • Transmembrane GTPase MFN1

Background

When mitochondria are impaired by genetic mutations or viral insertions, they are selectively isolated and destroyed by complicated intracellular mechanisms. The mitochondrial fusion-promoting factor MFN1 is a critical contributor to mediating this selective process. MFN1 is ubiquinated by PINK1 after its recruitment by Parkin, and this post-translational modification is critical in catalyzing mitochondrial repair or removal by other cellular mechanisms. In both Parkinson's and Alzheimer's disease, as well as when viruses attempt to replicate, mitochondrial fission and mitophagy are erroneously regulated due to the mutation or elimination of MFN1. This disruption of mitochondrial repair and regulation is implicated in many of the phenotypic demonstrations of neurodegenerative disorders.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Mitofusin 1 Antibody (NBP1-71775R) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Biotin Labeled NBP1-71775B
DyLight 350 Labeled NBP1-71775UV
DyLight 405 Labeled NBP1-71775V
DyLight 488 Labeled NBP1-71775G
DyLight 650 Labeled NBP1-71775C
DyLight 680 Labeled NBP1-71775FR
DyLight 755 Labeled NBP1-71775IR
FITC Labeled NBP1-71775F
HRP Labeled NBP1-71775H

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Bioinformatics Tool for Mitofusin 1 Antibody (NBP1-71775R)

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Bioinformatics

Gene Symbol MFN1
Entrez