mGluR8 Antibody (476410) [HRP]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC
Clone
476410
Clonality
Monoclonal
Host
Mouse
Conjugate
HRP

mGluR8 Antibody (476410) [HRP] Summary

Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human mGluR8
Gln34-Ser514 (predicted)
Accession # O00222
Specificity
Detects human mGluR8 in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human mGluR1, 2, 3, 4, 5, or 7 is observed.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
GRM8
Purity
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
No Preservative
Purity
Protein A or G purified from hybridoma culture supernatant

Alternate Names for mGluR8 Antibody (476410) [HRP]

  • FLJ41058
  • glutamate metabotropic receptor 8
  • glutamate receptor, metabotropic 8
  • GPRC1H
  • GPRC1HMGLUR8GLUR8
  • GRM8
  • metabotropic glutamate receptor 8
  • MGC126724
  • mGlu8
  • mGluR8

Background

The mGluR proteins (metabotropic glutamate receptors) are members of the G protein-coupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic glutamate receptors). The eight currently known mGluR proteins are mediated by two G proteins with opposing regulation of adenylate cyclase pathways. The activities of mGluR1 and mGluR5 are mediated by a G protein that activates a phosphatidylinositolcalcium second messenger system and generates a calcium-activated chloride current. The remainder of the eight subtypes of mGluR have an activity mediated by a G protein that inhibits adenylate cyclase activity. GLuR-8 is a group III metabotropic glutamate receptor. In response to glutamate stimulation, GLuR-8 activates GTP-binding proteins that modulate second-messenger cascades. Alternative splicing of this integral membrane protein produces three isoforms: a, b and c. Human GLuR-8 maps to q31.3-q32.1 of chromosome 7.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol GRM8