Species: Hu
Applications: WB, IHC
Host: Mouse Monoclonal
Species: Hu, Mu, Rt, Bt, Eq, Pm, Pm, Pm, Ma-Op
Applications: IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt, Bt, Ca, Ch, Eq, Ha, Pm, Pm, Rb, Sh, Pm, Fi, Ma-Op
Applications: IHC, ICC/IF
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB
Description
The mGluR proteins (metabotropic glutamate receptors) are members of the G protein-coupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic glutamate receptors). The eight currently known mGluR proteins are mediated by two G proteins with opposing regulation of adenylate cyclase pathways. The activities of mGluR1 and mGluR5 are mediated by a G protein that activates a phosphatidylinositolcalcium second messenger system and generates a calcium-activated chloride current. The remainder of the eight subtypes of mGluR have an activity mediated by a G protein that inhibits adenylate cyclase activity. GLuR-8 is a group III metabotropic glutamate receptor. In response to glutamate stimulation, GLuR-8 activates GTP-binding proteins that modulate second-messenger cascades. Alternative splicing of this integral membrane protein produces three isoforms: a, b and c. Human GLuR-8 maps to q31.3-q32.1 of chromosome 7.
Bioinformatics
| Entrez |
Mouse
Human
Rat
|
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
2918 |
| Alternate Names |
- FLJ41058
- glutamate metabotropic receptor 8
- glutamate receptor, metabotropic 8
- GPRC1HMGLUR8GLUR8
- metabotropic glutamate receptor 8
- MGC126724
- mGlu8
- mGluR8
|
