Meprin beta Subunit/MEP1B Antibody - BSA Free

Immunohistochemistry-Paraffin: Meprin beta Subunit/MEP1B Antibody [NBP2-37865] - Staining in human small intestine and liver tissues using anti-MEP1B antibody. Corresponding MEP1B RNA-seq data are presented for the same tissues.

Immunohistochemistry-Paraffin: Meprin beta Subunit/MEP1B Antibody [NBP2-37865] - Staining of human liver shows low expression as expected.

Immunohistochemistry-Paraffin: Meprin beta Subunit/MEP1B Antibody [NBP2-37865] - Staining of human small intestine shows high expression.

Immunohistochemistry-Paraffin: Meprin beta Subunit/MEP1B Antibody [NBP2-37865] -Staining of human skeletal muscle shows no positivity in myocytes as expected.

Immunohistochemistry-Paraffin: Meprin beta Subunit/MEP1B Antibody [NBP2-37865] -Staining of human tonsil shows no positivity in non-germinal center cells as expected.

• Reactivity: Hu
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

Meprin beta Subunit/MEP1B Antibody - BSA Free Summary

• Immunogen: This antibody was developed against a recombinant protein corresponding to amino acids: MTTDNGNYFWDRPSKVGTVALFPNGTQFRRGGGYGTSAFITHERLKSRDFIKGDDVYILLTVEDISHLNSTQIQLTPAPSVQDLCSKTTCKNDGVCTVRDGKAECRC
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MEP1B
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:20 - 1:50
  • Immunohistochemistry-Paraffin 1:20 - 1:50
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.
• Control Peptide:

  Meprin beta Subunit/MEP1B Protein (NBP2-37865PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for Meprin beta Subunit/MEP1B Antibody - BSA Free

• EC 3.4.24.63
• endopeptidase-2
• MEP1B
• meprin A subunit beta
• meprin A, beta
• Meprin B
• Meprin beta Subunit
• N-benzoyl-L-tyrosyl-p-amino-benzoic acid hydrolase beta subunit
• N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta
• PABA peptide hydrolase
• PPH beta

Background

Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes and in leukocytes and certain cancer cells. Mature meprins are oligomers of evolutionarily related, separately encoded alpha and/or beta subunits. Homooligomers of meprin-alpha are secreted; oligomers containing meprin-beta are associated with the plasma membrane. Substrates include bioactive peptides and extracellular matrix proteins.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MEP1B
• Uniprot:
  • Q16820()