Matrilin-1 Antibody

Western Blot: Matrilin-1 Antibody [NBP1-76325] - Mouse liver tissue lysate with MATN1 antibody at (A) 1 and (B) 2 ug/mL.

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Concentration: 1 mg/ml

Matrilin-1 Antibody Summary

• Immunogen: Antibody was raised against a 12 amino acid synthetic peptide from near the amino terminus of human MATN1. The immunogen is located within amino acids 120 - 170 of MATN1.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MATN1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
• Control Peptide:

  Matrilin-1 Peptide (NBP1-76325PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Matrilin-1 Antibody

• cartilage matrix protein
• CMP
• CRTM
• MATN1
• matrilin 1, cartilage matrix protein
• Matrilin1
• Matrilin-1

Background

Matrilins (MATNs) are a family of non-collagenous extra-cellular matrix (ECM) proteins consisting of four known members that have been proposed to play key roles in modulating cellular phenotypes during chondrogenesis of mesenchymal stem cells (MSCs). MATN1 and MATN3 are expressed specifically in cartilage and are among the most up-regulated ECM proteins during chondrogenesis. MATN1 is composed of two Willebrand Factor A (vWFA) domains separated by one EGF-like domain, whereas MATN3 is composed of a single N-terminal vWFA domain followed by four epidermal growth factor (EGF) repeats and a coiled-coil domain. MATN1 or MATN3 may play a role in modulating chondrogenesis during the chondrocyte differentiation process. Mutations of this gene have been associated with variety of inherited chondrodysplasias. Recent studies show that the MATN1 promoter region was associated with both susceptibility and disease progression in Adolescent idiopathic scoliosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MATN1
• Entrez:
  • 4146(Human)
  • 17180(Mouse)
  • 297894(Rat)
• Uniprot:
  • NP_002370(Human)