M-CSFR/CD115 Antibody (460615) [FITC]

M-CSFR/CD115 Antibody (460615) [FITC] [FAB3818F] - Vial of FITC conjugated antibody. FITC is optimally excited at 498 nm by the Blue laser (488 nm) and has an emission maximum of 519 nm.

• Reactivity: Mu
• Applications: Flow, CyTOF-ready
• Clone: 460615
• Clonality: Monoclonal
• Host: Rat
• Conjugate: FITC

M-CSFR/CD115 Antibody (460615) [FITC] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse M-CSF R/CD115
  Ala20-Ser511
  Accession # P09581
• Specificity: Detects mouse M-CSF R/CD115 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human M-CSF R/CD115, recombinant mouse (rm) PDGF R beta , or rmFlt-3 Ligand is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Rat
• Gene: CSF1R
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Alternate Names for M-CSFR/CD115 Antibody (460615) [FITC]

• CD115 antigen
• CD115
• c-fms
• colony stimulating factor 1 receptor
• CSF1R
• CSF-1-R
• CSFR
• EC 2.7.10.1
• FMS proto-oncogene
• FMSFIM2
• macrophage colony stimulating factor I receptor
• macrophage colony-stimulating factor 1 receptor
• McDonough feline sarcoma viral (v-fms) oncogene homolog
• M-CSF R
• MCSFR
• M-CSFR
• Proto-oncogene c-Fms

Background

MCSF Receptor is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a member of the CSF1/PDGF receptor family of tyrosine protein kinases and contains 5 immunoglobulin like C2 type domains. CD115 is expressed by cells of the monocytic lineage and by progenitor cells. Mutations in this gene have been associated with a predisposition to myeloid malignancy.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CSF1R