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HAF007). A specific band was detected for M-CSF R/CD115 at approximately 130 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_lightbox" target="_blank">
329-MR) inhibits Recombinant Human M-CSF (Catalog # 216-MC) induced proliferation in the M-NFS-60 mouse myelogenous leukemia lymphoblast cell line in a dose-dependent manner (orange line). Inhibition of Recombinant Human M-CSF R/CD115 (1 ng/mL) activity elicited by Recombinant Human M-CSF R/CD115 Fc Chimera (30 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human M-CSF R/CD115 Monoclonal Antibody (Catalog # MAB3291). The ND50 is typically 4-16 ng/mL." class="big_lightbox" target="_blank">
VC001). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using VisUCyte Antigen Retrieval Reagent-Basic (Catalog # VCTS021). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cell surface and cytoplasm in lymphocytes. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents." class="big_lightbox" target="_blank">
MCSF Receptor is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a member of the CSF1/PDGF receptor family of tyrosine protein kinases and contains 5 immunoglobulin like C2 type domains. CD115 is expressed by cells of the monocytic lineage and by progenitor cells. Mutations in this gene have been associated with a predisposition to myeloid malignancy.
![Western Blot M-CSFR/CD115 Antibody (61701) [Unconjugated]](http://images.novusbio.com/images/antibody/M-CSF_R_MAB3291_Western_Blot_7396.jpg)
![Immunocytochemistry M-CSFR/CD115 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/M-CSF_R_AF3818_Immunocytochemistry_10191.jpg)
![N/A M-CSFR/CD115 [Biotin]](http://images.novusbio.com/fullsize/elisa/DATA_MCSF_R_DY329_ELISA_1932.jpg)
![ELISA M-CSFR/CD115 [Biotin]](http://images.novusbio.com/fullsize/dyc3268-2_human-phospho-m-csf-r-duoset-ic-elisa-2-plate-elisa-3012202093930.png)
![Binding Activity M-CSFR/CD115 [Biotin]](http://images.novusbio.com/fullsize/protein/MCSF_R_AVI10339_3020.jpg)
![Neutralization M-CSFR/CD115 Antibody (61701) [Unconjugated]](http://images.novusbio.com/images/antibody/M-CSF_R_MAB3291_Block_Neutralize_2359.jpg)
![Immunohistochemistry M-CSFR/CD115 Antibody (61701) [Unconjugated]](http://images.novusbio.com/images/antibody/mab3291_human-m-csf-r-cd115-mab-clone-61701-immunohistochemistry-10102023145649..jpg)
![Western Blot M-CSFR/CD115 Antibody (61701) [Unconjugated]](http://images.novusbio.com/fullsize/mab3291_human-m-csf-r-cd115-mab-clone-61701-western-blot-12122025549581.jpg)
![ELISA M-CSFR/CD115 [Biotin]](http://images.novusbio.com/fullsize/dyc3268-2_human-phospho-m-csf-r-duoset-ic-elisa-2-plate-elisa-3012202094033.png)
![ELISA M-CSFR/CD115 [Biotin]](http://images.novusbio.com/fullsize/dyc3268-2_human-phospho-m-csf-r-duoset-ic-elisa-2-plate-elisa-3012202094215.png)
![SDS-Page M-CSFR/CD115 [Biotin]](http://images.novusbio.com/fullsize/protein/MCSF_R_AVI10339_2898.jpg)
