Lysyl Oxidase Homolog 3/LOXL3 Antibody

Product Discontinued

Lysyl Oxidase Homolog 3/LOXL3 Antibody Summary

• Immunogen: LOXL3 (NP_115992, 171 a.a. ~ 271 a.a) partial recombinant protein with GST tag.IRPAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTAR
• Specificity: LOXL3 - lysyl oxidase-like 3
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: LOXL3
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot 1:500
• Application Notes: Antibody reactive against cell lysate and recombinant protein for western blot. It has also been used for ELISA.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: 50% Glycerol
• Preservative: No Preservative
• Purity: Unpurified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Lysyl Oxidase Homolog 3/LOXL3 Antibody

• EC 1.4.3
• EC 1.4.3.-
• EC 1.4.3.13
• LOL3
• LOXL
• LOXL3
• Lysyl Oxidase Homolog 3
• lysyl oxidase-like 3
• Lysyl oxidase-like protein 3

Background

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Lysyl Oxidase Homolog 3/LOXL3 Antibody (H00084695-A01)(1)

Publication using H00084695-A01

• Alarab M, Bortolini MA, Drutz H et al. LOX family enzymes expression in vaginal tissue of premenopausal women with severe pelvic organ prolapse. Int Urogynecol J Pelvic Floor Dysfunct. 2010-06-18 [PMID: 20559617]

Bioinformatics

• Gene Symbol: LOXL3
• Entrez:
  • 84695(Human)
• OMIM:
  • 607163(Human)
• Uniprot:
  • NP_115992()