LOXL4 Antibody (4H7) - Azide and BSA Free

Sandwich ELISA: LOXL4 Antibody (4H7) [H00084171-M01] - Detection limit for recombinant GST tagged LOXL4 is 0.3 ng/ml as a capture antibody.

• Reactivity: Hu
• Applications: WB, ELISA
• Clone: 4H7
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: Azide and BSA Free

LOXL4 Antibody (4H7) - Azide and BSA Free Summary

• Immunogen: LOXL4 (NP_115587, 657 a.a. ~ 755 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. ACANFGEQGVTVGCWDTYRHDIDCQWVDITDVGPGNYIFQVIVNPHYEVAESDFSNNMLQCRCKYDGHRVWLHNCHTGNSYPANAELSLEQEQRLRNNL
• Specificity: LOXL4 - lysyl oxidase-like 4
• Isotype: IgG3 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: LOXL4
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Sandwich ELISA
  • Western Blot 1:500
• Application Notes: Antibody Reactive against Recombinant Protein with GST tag on ELISA and Western Blot. GST tag alone is used as a negative control.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: In 1x PBS, pH 7.4
• Preservative: No Preservative
• Purity: IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for LOXL4 Antibody (4H7) - Azide and BSA Free

• EC 1.4.3
• EC 1.4.3.-
• FLJ21889
• LOX L4
• LOXC
• LOXClysyl oxidase related C
• LOXL4
• lysyl oxidase homolog 4
• lysyl oxidase-like 4
• Lysyl oxidase-like protein 4
• Lysyl oxidase-related protein C

Background

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for LOXL4 Antibody (H00084171-M01)(3)

Publications using H00084171-M01

• Wu S, Zheng Q, Xing X et al. Matrix stiffness-upregulated LOXL2 promotes fibronectin production, MMP9 and CXCL12 expression and BMDCs recruitment to assist pre-metastatic niche formation. J Exp Clin Cancer Res 2018-05-04 [PMID: 29728125]
• Wong CC, Zhang H, Gilkes DM et al. Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis. J Mol Med (Berl) 2012-07-01 [PMID: 22231744] (WB, Human)
• Wong CC, Gilkes DM, Zhang H et al. Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Proc Natl Acad Sci U S A. 2011-09-01 [PMID: 21911388]

Reviews for LOXL4 Antibody (H00084171-M01) (2)

Average Rating: 3

(Based on 2 reviews)

We have 2 reviews tested in 1 species: Human.

reviewed by: Carmen Wong WB Human 08/02/2010

Summary

• Application: Western Blot
• Sample Tested: Cancer Cell lysate
• Species: Human

reviewed by: Verified Customer WB Human 06/14/2010

Summary

• Application: Western Blot
• Sample Tested: MDA231, Sample Amount: 100 ug
• Species: Human
• Lot: 7186-447 00AdE

Bioinformatics

• Gene Symbol: LOXL4
• Entrez:
  • 84171(Human)
• OMIM:
  • 607318(Human)
• Uniprot:
  • NP_115587(Human)