Lysyl Oxidase Homolog 3/LOXL3 Antibody (1013358) [Alexa Fluor® 350]

• Reactivity: Hu
• Applications: ELISA
• Clone: 1013358
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 350

Lysyl Oxidase Homolog 3/LOXL3 Antibody (1013358) [Alexa Fluor® 350] Summary

• Immunogen: Chinese Hamster Ovary cell line CHO-derived human Lysyl Oxidase Homolog 3/LOXL3 protein
  Met1-Ile753
  Accession # P58215
• Specificity: Detects human Lysyl Oxidase Homolog 3/LOXL3 protein in direct ELISAs.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • ELISA

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Lysyl Oxidase Homolog 3/LOXL3 Antibody (1013358) [Alexa Fluor® 350]

• EC 1.4.3
• EC 1.4.3.-
• EC 1.4.3.13
• LOL3
• LOXL
• LOXL3
• Lysyl Oxidase Homolog 3
• lysyl oxidase-like 3
• Lysyl oxidase-like protein 3

Background

Lysyl oxidase-like protein 3 (LOXL3) is a secreted copper amine oxidase. The N-terminal region of LOXL3 contains four scavenger receptor cysteine-rich (SRCR) domains. The C-terminal region consists of a catalytic domain similar to other lysyl oxidases and a cytokine receptor-like domain (1). The catalytic domain contains conserved residues required for copper binding and formation of a lysyl tyrosylquinone cofactor (2). LOXL3 is expressed primarily in epidermis, kidney, aorta, and chondrocytes (3). The enzyme is expressed at low levels in most other tissues. Like lysyl oxidase, LOXL3 oxidizes the lysine epsilon -amino groups of a number of collagen substrates, and is also active against other primary amines (4). However, LOXL3 does not require proteolytic processing to be activated.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.