LXR Antibody [DyLight 405]


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Product Details

Reactivity Hu, Mu, Po, Pm, Rt, ChSpecies Glossary
Applications WB
DyLight 405

LXR Antibody [DyLight 405] Summary

A synthetic peptide made to an internal portion of the human LXR protein sequence (between residues 50-150). [UniProt# Q13133]
Nuclear (potential)
Predicted Species
Rat (92%), Chicken (90%). Backed by our 100% Guarantee.
Immunogen affinity purified
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  • Western Blot
Application Notes
This LXR antibody is useful for Western blot, where a band is observed at ~50 kDa.

Reactivity Notes

Human, mouse, porcine and monkey. Immunogen sequence has 92% identity to rat and 90% identity to chicken.

Packaging, Storage & Formulations

Store at 4C in the dark.
50mM Sodium Borate
0.05% Sodium Azide
Immunogen affinity purified


Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for LXR Antibody [DyLight 405]

  • alpha
  • Liver X receptor alpha
  • liver X receptor-alpha
  • LXRA
  • Nuclear receptor subfamily 1 group H member 3
  • nuclear receptor subfamily 1, group H, member 3
  • oxysterols receptor LXR-alpha
  • RLD-1


LXR (liver X receptors - LXR-alpha and LXR-beta, encoded by NR1H3 and NR1H2, respectively) belongs to nuclear hormone receptor superfamily and are ligand-dependent nuclear transcription factors which are activated by oxysterols. LXR beta is ubiquitously expressed whereas LXR alpha is expressed mainly in liver, intestine, adipose tissue and macrophages. LXR-alpha and LXR-beta shares 78% similarity within their ligand-binding domains and form obligate heterodimers with retinoic X receptor (RXR), bind specific response elements within promoters of target genes ABCA1, ABCG1, SREBF1, APOE etc., and regulate their expression. In the unliganded state, LXRs binds with corepressors such as N-CoR which displaces upon ligand binding. Oxysterols (oxidized cholesterol derivatives) are their natural ligands whereas endogenous ligands includes 22(R)-hydroxycholesterol (22-HC), 24(S)-hydroxycholesterol (24(S)-HC), 24,25-EC, 27-hydroxycholesterol etc. LXRs control the major metabolic pathways such as cholesterol homeostasis, lipogenesis, inflammation, toxicity proliferation cell survival/death and different aspacts of acquired/innate immunity.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

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Secondary Antibodies


Isotype Controls

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LXR NB400-157V

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Research Areas for LXR Antibody (NB400-157V)

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Blogs on LXR.

ABCA1 (ATP-binding cassette transporter A1)
The ABCA1 molecule is a primary gatekeeper for regulating the intracellular transport of cholesterol. It belongs to a larger related multifamily of cAMP-dependent anion transporter cell membrane molecules. These key proteins are responsible for tr...  Read full blog post.

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Gene Symbol NR1H3