LXR Antibody [DyLight 405]


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Product Details

Reactivity Hu, Mu, Po, PmSpecies Glossary
Applications WB
Please see the vial label for concentration. If unlisted please contact technical services.

LXR Antibody [DyLight 405] Summary

A synthetic peptide made to an internal portion of the human LXR protein sequence (between residues 50-150). [UniProt# Q13133]
Nuclear (potential)
Predicted Species
Rat (92%), Chicken (90%)
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at 4C in the dark.
DyLight 405
DyLight 405 (A=400, E=420)
50mM Sodium Borate
0.05% Sodium Azide
Please see the vial label for concentration. If unlisted please contact technical services.
Immunogen affinity purified


Application Notes
This LXR antibody is useful for Western blot, where a band is observed at ~50 kDa.

Reactivity Notes

Human, mouse, porcine and monkey. Immunogen sequence has 92% identity to rat and 90% identity to chicken.

Alternate Names for LXR Antibody [DyLight 405]

  • alpha
  • Liver X receptor alpha
  • liver X receptor-alpha
  • LXRA
  • Nuclear receptor subfamily 1 group H member 3
  • nuclear receptor subfamily 1, group H, member 3
  • oxysterols receptor LXR-alpha
  • RLD-1


LXR (liver X receptors - LXR-alpha and LXR-beta, encoded by NR1H3 and NR1H2, respectively) belongs to nuclear hormone receptor superfamily and are ligand-dependent nuclear transcription factors which are activated by oxysterols. LXR beta is ubiquitously expressed whereas LXR alpha is expressed mainly in liver, intestine, adipose tissue and macrophages. LXR-alpha and LXR-beta shares 78% similarity within their ligand-binding domains and form obligate heterodimers with retinoic X receptor (RXR), bind specific response elements within promoters of target genes ABCA1, ABCG1, SREBF1, APOE etc., and regulate their expression. In the unliganded state, LXRs binds with corepressors such as N-CoR which displaces upon ligand binding. Oxysterols (oxidized cholesterol derivatives) are their natural ligands whereas endogenous ligands includes 22(R)-hydroxycholesterol (22-HC), 24(S)-hydroxycholesterol (24(S)-HC), 24,25-EC, 27-hydroxycholesterol etc. LXRs control the major metabolic pathways such as cholesterol homeostasis, lipogenesis, inflammation, toxicity proliferation cell survival/death and different aspacts of acquired/innate immunity.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies


Isotype Controls

Additional LXR Antibody [DyLight 405] Products

LXR NB400-157V

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Research Areas for LXR Antibody (NB400-157V)

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Blogs on LXR.

ABCA1 (ATP-binding cassette transporter A1)
The ABCA1 molecule is a primary gatekeeper for regulating the intracellular transport of cholesterol. It belongs to a larger related multifamily of cAMP-dependent anion transporter cell membrane molecules. These key proteins are responsible for tr...  Read full blog post.

Contact Information

Product PDFs


Gene Symbol NR1H3

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