LXR alpha/NR1H3 Antibody


Western Blot: LXR alpha/NR1H3 Antibody [NB300-612] - LXRs are expressed in peripheral blood cells. LXR alpha/NR1H3 protein levels in protein extracts from PBMCs from these same donors were detected by Western blotting ...read more
Immunocytochemistry/ Immunofluorescence: LXR alpha/NR1H3 Antibody [NB300-612] - Analysis of LXR alpha (green) showing staining in the nucleus of Hela cells (right) compared to a negative control without primary antibody ...read more
Flow Cytometry: LXR alpha/NR1H3 Antibody [NB300-612] - analysis of LXR alpha was done on HeLa. Cells were fixed with 70% ethanol for 10 minutes, permeabilized with 0.25% Triton X-100 for 20 minutes, and blocked with ...read more
Western Blot: LXR alpha/NR1H3 Antibody [NB300-612] - analysis was performed on nuclear enriched extracts (30 ug lysate) of MCF7 (Lane 1), THP-1 (Lane 2), A549 (Lane 3), SH-SY5Y (Lane 4), HL-60 (Lane 5) and KARPAS 299 ...read more
Immunocytochemistry/ Immunofluorescence: LXR alpha/NR1H3 Antibody [NB300-612] - Analysis of LXR alpha (green) showing staining in the nucleus of MCF-7 cells (right) compared to a negative control without primary ...read more

Product Details

Reactivity Hu, MuSpecies Glossary
Applications WB, Flow, GS, ICC/IF, IHC
1 mg/ml

Order Details

LXR alpha/NR1H3 Antibody Summary

Synthetic peptide corresponding to residues C D(318) F S Y N R E D F A K A(329) of human LXR alpha.
Detects recombinant human LXR alpha. This does not detect recombinant human LXR beta.
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Flow Cytometry 3-5ug/10^6 cells
  • Gel Super Shift Assays 1:1 - 1:100
  • Immunocytochemistry/Immunofluorescence 1:50-1:500
  • Immunohistochemistry 1:10-1:500
  • Western Blot 1:300
Application Notes
WB: Detects an approx. 64 kDa protein representing recombinant human LXR alpha.
IHC usage was reported in the scientific literature (PMID: 17393442).
Gel Shift Assays usage was reported in the scientific literature (PMID: 12470667).
Read Publications using
NB300-612 in the following applications:

  • WB
    3 publications

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 17393442).

Packaging, Storage & Formulations

Store at -20C. Avoid freeze-thaw cycles.
PBS with 1 mg/ml BSA
0.05% Sodium Azide
1 mg/ml
Immunogen affinity purified

Alternate Names for LXR alpha/NR1H3 Antibody

  • alpha
  • Liver X receptor alpha
  • liver X receptor-alpha
  • LXR alpha
  • LXRA
  • NR1H3
  • Nuclear receptor subfamily 1 group H member 3
  • nuclear receptor subfamily 1, group H, member 3
  • oxysterols receptor LXR-alpha
  • RLD-1


Liver X Receptors (LXRs) are oxysterol activated nuclear receptors which are involved in the regulation of cholesterol metabolism and bile acids. Two known isoforms, alpha and beta, are differentially expressed. The alpha isoform is predominantly expressed in liver, whereas the beta isoform expression has been shown to be ubiquitous.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for LXR alpha/NR1H3 Antibody (NB300-612)(9)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: WB.

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Showing Publications 1 - 9 of 9.
Publications using NB300-612 Applications Species
Palma GBH, Kaur M miRNA-128 and miRNA-223 regulate cholesterol-mediated drug resistance in breast cancer IUBMB life 2023-04-18 [PMID: 37070323] (WB, Human) WB Human
(WB, Mouse) WB Mouse
Shen C, Jiang J, Huang C, Zhu W. Gypenoside LVI attenuates foam cell formation by promoting cholesterol export and inhibiting inflammation response Oncotarget 2018-10-05
Bruschi FV, Claudel T, Tardelli M et al. PNPLA3 I148M Variant Impairs Liver X Receptor Signaling and Cholesterol Homeostasis in Human Hepatic Stellate Cells Hepatol Commun 2019-09-01 [PMID: 31497741] (WB, Human) WB Human
Abuirqeba SA The Role of Liver X Receptor in Prostate Cancer Metabolism Thesis 1905-07-13
Poomthavorn P, Wong SHX, Higgins S et al. Activation of a prometastatic gene expression program in hypoxic neuroblastoma cells. Endocr Relat Cancer;16(3):991-1004. 2009-01-01 [PMID: 19423615]
Dang H, Liu Y, Pang W et al. Suppression of 2,3-Oxidosqualene Cyclase by High Fat Diet Contributes to Liver X Receptor-{alpha}-mediated Improvement of Hepatic Lipid Profile. J Biol Chem;284(10):6218-6226. 2009-01-01 [PMID: 19119143]
DiBlasio-Smith EA, Arai M, Quinet EM et al. Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells (BioMed Central). J Transl Med. 2008-01-01 [PMID: 18925943]
Zhang, C et al. NO-1886 suppressing atherosclerosis in high-fat-high-sucrose/high-cholesterol fed Bama minipigs is related to upregulating ATP-binding cassette transporter A1. J Lipid Res. 2006-01-01 [PMID: 16807312]

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WB Video Protocol
ICC/IF Video Protocol

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Gene Symbol NR1H3