Partial recombinant human Lin28 protein expressed in E. coli. [Swiss-Prot# Q9H9Z2]
Cytoplasm. Nucleus - nucleolus. Notes: Nucleolar localization observed in 10-15% of the nuclei in differentiated myotubes. Shuttles between the cytoplasm and the nucleus. Localizes to cytoplasmic processing bodies and stress granules.
Undifferentiated human embryonic stem cell Marker
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Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
0.1% Sodium Azide
Alternate Names for LIN-28A Antibody
lin-28 homolog (C. elegans)
lin-28 homolog A (C. elegans)
LIN28RNA-binding protein LIN-28
ZCCHC1protein lin-28 homolog A
Zinc finger CCHC domain-containing protein 1
zinc finger, CCHC domain containing 1
Lin28 acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Lin28 is a marker of undifferentiated human embryonic stem cells and has been used to enhance the efficiency of the formation of induced pluripotent stem (iPS) cells from human fibroblasts. Lin28 has also been shown to bind to the let-7 pre-miRNA and block production of the mature let-7 microRNA in mouse embryonic stem cells.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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