Mouse myeloma cell line NS0-derived recombinant human LIGHT/TNFSF14 Asp74-Val240 Accession # O43557
Detects human LIGHT/TNFSF14 in direct ELISAs and Western blots. In Western blots, approximately 5% cross-reactivity with recombinant human (rh) APRIL is observed and less than 1% cross-reactivity with rhFas Ligand, rhTRAIL, and rhTNF-alpha is observed.
<0.10 EU per 1 μg of the antibody by the LAL method.
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Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Reconstitute at 0.2 mg/mL in sterile PBS.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for LIGHT/TNFSF14 Antibody [Unconjugated]
delta transmembrane LIGHT
Herpes virus entry mediator ligand
Herpesvirus entry mediator ligand
HVEMLherpesvirus entry mediator-ligand
ligand for herpesvirus entry mediator
LIGHTherpesvirus entry mediator A
tumor necrosis factor (ligand) superfamily, member 14
tumor necrosis factor ligand superfamily member 14
tumor necrosis factor receptor-like 2
tumor necrosis factor superfamily member LIGHT
Human LIGHT is a type II membrane protein that is a member of the TNF superfamily. LIGHT is an acronym which stands for "is homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes". LIGHT has also been called HVEM-L and LT-gamma. Under the new TNF nomenclature, it is called TNFSF14. LIGHT is a 240 amino acid (aa) protein that contains a 37 aa cytoplasmic domain, a 22 aa transmembrane region, and a 181 aa extracellular domain. Similar to other TNF ligand family members, LIGHT is predicted to assemble as a homotrimer. LIGHT is produced by activated T cells and was first identified by its ability to compete with HSV glycoprotein D for HVEM binding. LIGHT has also been shown to bind to the lymphotoxin beta receptor (LT beta R) and the decoy receptor (DcR3/TR6). LIGHT overexpression in tumor cells induces apoptosis, which can be enhanced by IFN-gamma. The full roles of LIGHT remain to be elucidated.
Mauri, D.N. et al. (1998) Immunity 8:21.
Zhai, Y. et al. (1998) J. Clin. Invest. 102:1142.
Harrop, J.A. et al. (1998) J. Biol. Chem. 273:27548.
Yu, K-Y. et al. (1999) J. Biol. Chem. 274:13733.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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