Langerin/CD207 Antibody (817G7) - Azide and BSA Free

Flow Cytometry: Langerin/CD207 Antibody (817G7) [DDX0377P-100]

Flow Cytometry: Langerin/CD207 Antibody (817G7) [DDX0377P-100]

• Reactivity: Hu
• Applications: Flow, Func, Inhibition Activity
• Clone: 817G7
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: Azide and BSA Free
• Concentration: 0.5 mg/ml

Langerin/CD207 Antibody (817G7) - Azide and BSA Free Summary

• Description: Novus Biologicals Mouse Langerin/CD207 Antibody (817G7) - Azide and BSA Free (DDX0377P-100) is a monoclonal antibody validated for use in Flow. Anti-Langerin/CD207 Antibody: Cited in 8 publications. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: human Langerin-transfected eukaryotic cells
• Epitope: Recognizes the CRD domain of the langerin molecule.
• Specificity: human Langerin (extracellular epitope)
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: CD207
• Purity: Ion exchange chromatography

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 1:10-1:1000
  • Functional
  • Inhibition Activity
• Application Notes: Use in Inhibition Activity reported in scientific literature (PMID:33905459) This monoclonal antibody may be used between 5-20 ug/ml. Blocks HIV-gp120

Reactivity Notes

Human

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris-NaCl (pH 8.0)
• Preservative: No Preservative
• Concentration: 0.5 mg/ml
• Purity: Ion exchange chromatography

Notes

This product is manufactured by Eurobio Scientific (formerly Dendritics) and distributed by Novus Biologicals.

Alternate Names for Langerin/CD207 Antibody (817G7) - Azide and BSA Free

• CD207 antigen
• CD207 antigen, langerin
• CD207 molecule, langerin
• CD207
• CLEC4KLangerhans cell specific c-type lectin
• C-type lectin domain family 4 member K
• C-type lectin domain family 4, member K
• Langerin

Background

Langerin (CD207) is a type II membrane-associated C-type lectin known to be expressed exclusively by Langerhans cells. Langerin recognizes mannose residues via its single carbohydrate recognition domain (CRD). Langerin is localized not only on the cell surface, but also intracellularly in close association with Birbeck granules. Transfection of Langerin cDNA into fibroblasts creates a compact network of membrane structures with typical features of Birbeck granules (BG). Langerin is thus a potent inducer of membrane superimposition and zippering leading to BG formation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Langerin/CD207 Antibody (DDX0377P-100)(8)

Publications using DDX0377P-100

• Bertram KM, Truong NR, Smith JB et al. Herpes Simplex Virus type 1 infects Langerhans cells and the novel epidermal dendritic cell, Epi-cDC2s, via different entry pathways PLoS pathogens 2021-04-27 [PMID: 33905459] (In-Cell Western (ICW), Human)
• Luckashenak N et al. Rho-family GTPase Cdc42 controls migration of Langerhans cells in vivo. J Immunol 2013-01-01 [PMID: 23209325]
• Hitzler M et al. Human Langerhans cells control Th cells via programmed death-ligand 1 in response to bacterial stimuli and nickel-induced contact allergy. PLoS One 2012-01-01 [PMID: 23056446]
• Iram N et al. Age-related changes in expression and function of Toll-like receptors in human skin. Development 2012-11-01 [PMID: 23034637]
• Segura E et al. Characterization of resident and migratory dendritic cells in human lymph nodes. J Exp Med 2012-04-09 [PMID: 22430490]
• Douillard P et al. Mouse lymphoid tissue contains distinct subsets of langerin/CD207 dendritic cells, only one of which represents epidermal-derived Langerhans cells. J Invest Dermatol 2005-11-01 [PMID: 16297200]
• Movassagh M et al. Selective accumulation of mature DC-Lamp+ dendritic cells in tumor sites is associated with efficient T-cell-mediated antitumor response and control of metastatic dissemination in melanoma. Cancer Res 2004-03-15 [PMID: 15026362]
• Valladeau J et al. Identification of mouse langerin/CD207 in Langerhans cells and some dendritic cells of lymphoid tissues. J Immunol 2002-01-15 [PMID: 11777972]

Bioinformatics

• Gene Symbol: CD207