Langerin/CD207 Antibody (306G9) - Azide and BSA Free

Immunohistochemistry: Langerin/CD207 Antibody (306G9) [DDX0368P-100] - IHC staining ofLangerhans cellsinporcine skin tissuesection

Flow Cytometry: Langerin/CD207 Antibody (306G9) [DDX0368P-100] - Facs analysis of mouseLangerin-transfected COP5cells stained with 306G9antibody

Immunohistochemistry: Langerin/CD207 Antibody (306G9) [DDX0368P-100] - IHC staining of human skinfrozen section with 306G9antibody

Immunohistochemistry: Langerin/CD207 Antibody (306G9) [DDX0368P-100] - IHC staining of human skinparaffin section with 306G9antibody

Flow Cytometry: Langerin/CD207 Antibody (306G9) [DDX0368P-100] - Facs double-stainingof porcine skinderivedDCs

• Reactivity: Hu, Mu, Rt, Po
• Applications: Flow, IHC
• Clone: 306G9
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: Azide and BSA Free
• Concentration: 0.5 mg/ml

Langerin/CD207 Antibody (306G9) - Azide and BSA Free Summary

• Description: Novus Biologicals Mouse Langerin/CD207 Antibody (306G9) - Azide and BSA Free (DDX0368P-100) is a monoclonal antibody validated for use in IHC and Flow. Anti-Langerin/CD207 Antibody: Cited in 12 publications. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Langerin/CD207 was used as immunogen.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: CD207
• Purity: Ion exchange chromatography

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 1:10-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500

Reactivity Notes

Mouse, Human, Porcine, Rat

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris-NaCl (pH 8.0)
• Preservative: No Preservative
• Concentration: 0.5 mg/ml
• Purity: Ion exchange chromatography

Notes

This product is manufactured by Eurobio Scientific (formerly Dendritics) and distributed by Novus Biologicals.

Alternate Names for Langerin/CD207 Antibody (306G9) - Azide and BSA Free

• CD207 antigen
• CD207 antigen, langerin
• CD207 molecule, langerin
• CD207
• CLEC4KLangerhans cell specific c-type lectin
• C-type lectin domain family 4 member K
• C-type lectin domain family 4, member K
• Langerin

Background

Langerin (CD207) is a type II membrane-associated C-type lectin known to be expressed exclusively by Langerhans cells. Langerin recognizes mannose residues via its single carbohydrate recognition domain (CRD). Langerin is localized not only on the cell surface, but also intracellularly in close association with Birbeck granules. Transfection of Langerin cDNA into fibroblasts creates a compact network of membrane structures with typical features of Birbeck granules (BG). Langerin is thus a potent inducer of membrane superimposition and zippering leading to BG formation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Langerin/CD207 Antibody (DDX0368P-100)(12)

Publications using DDX0368P-100

• Robinson H, Jarrett P, Vedhara K et al. The effect of expressive writing on wound healing: Immunohistochemistry analysis of skin tissue two weeks after punch biopsy wounding Journal of Psychosomatic Research 2022-10-01 [PMID: 35917660] (IHC-Fr, Human)
• Debeer S et al. Comparative histology and immunohistochemistry of porcine versus human skin. Eur J Dermatol 2013-07-01 [PMID: 24047577]
• Luckashenak N et al. Rho-family GTPase Cdc42 controls migration of Langerhans cells in vivo. J Immunol 2013-01-01 [PMID: 23209325]
• Hitzler M et al. Human Langerhans cells control Th cells via programmed death-ligand 1 in response to bacterial stimuli and nickel-induced contact allergy. PLoS One 2012-01-01 [PMID: 23056446]
• Iram N et al. Age-related changes in expression and function of Toll-like receptors in human skin. Development 2012-11-01 [PMID: 23034637]
• Segura E et al. Characterization of resident and migratory dendritic cells in human lymph nodes. J Exp Med 2012-04-09 [PMID: 22430490]
• Bobr A et al. Acute ablation of Langerhans cells enhances skin immune responses. J Immunol 2010-10-15 [PMID: 20855870]
• deJong MA et al. Herpes simplex virus type 2 enhances HIV-1 susceptibility by affecting Langerhans cell function. J Immunol 2010-08-01 [PMID: 20592277]
• Nfon CK et al. Langerhans cells in porcine skin. Vet Immunol Immunopathol 2008-12-15 [PMID: 18805593]
• Movassagh M et al. Selective accumulation of mature DC-Lamp+ dendritic cells in tumor sites is associated with efficient T-cell-mediated antitumor response and control of metastatic dissemination in melanoma. Cancer Res 2004-03-15 [PMID: 15026362]
• Valladeau J et al. Identification of mouse langerin/CD207 in Langerhans cells and some dendritic cells of lymphoid tissues. J Immunol 2002-01-15 [PMID: 11777972]
• Henri S et al. The dendritic cell populations of mouse lymph nodes. J Immunol 2001-07-15 [PMID: 11441078]

Bioinformatics

• Gene Symbol: CD207