Kir3.4 Antibody

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Western Blot: Kir3.4 Antibody [NBP3-03006] - Analysis of extracts of various cell lines, using Kir3.4 antibody at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. ...read more

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

Kir3.4 Antibody Summary

Immunogen
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Kir3.4 (NP_000881.3).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
KCNJ5
Purity
Affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:2000
Theoretical MW
47 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS with 50% glycerol, pH7.3.
Preservative
0.02% Sodium Azide
Purity
Affinity purified

Alternate Names for Kir3.4 Antibody

  • Cardiac inward rectifier
  • CIRKIR3.4
  • G protein-activated inward rectifier potassium channel 4
  • GIRK-4
  • GIRK4Kir3.4
  • Heart KATP channel
  • Inward rectifier K(+) channel Kir3.4
  • inward rectifier K+ channel KIR3.4
  • IRK-4
  • KATP-1
  • KATP1cardiac ATP-sensitive potassium channel
  • LQT13
  • Potassium channel, inwardly rectifying subfamily J member 5
  • potassium inwardly-rectifying channel, subfamily J, member 5

Background

G-protein regulated inward-rectifier potassium channels (GIRK) are part of a superfamily of inward-rectifier K+ channels. To date four GIRK subunits, designated GIRK1-4 (also designated Kir3.1-4), have been identified in mammals, and GIRK5 has been found in Xenopus oocytes. GIRK channels exist in vivo both as homotetramers and heterotetramers. GIRK channels are modulated by G-proteins; they are also modulated by phosphatidylinositol 4,5-bisphosphate, intracellular sodium, ethanol and mechanical stretch. GIRK1, 2 and 3 are highly abundant in brain. In general, neuronal GIRK channels are involved in the regulation of the excitability of neurons and may contribute to the resting potential.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol KCNJ5