Kir3.4 Products

Description

G-protein regulated inward-rectifier potassium channels (GIRK) are part of a superfamily of inward-rectifier K+ channels. To date four GIRK subunits, designated GIRK1-4 (also designated Kir3.1-4), have been identified in mammals, and GIRK5 has been found in Xenopus oocytes. GIRK channels exist in vivo both as homotetramers and heterotetramers. GIRK channels are modulated by G-proteins; they are also modulated by phosphatidylinositol 4,5-bisphosphate, intracellular sodium, ethanol and mechanical stretch. GIRK1, 2 and 3 are highly abundant in brain. In general, neuronal GIRK channels are involved in the regulation of the excitability of neurons and may contribute to the resting potential.

Bioinformatics

Entrez	16521 Mouse 29173 Rat 3762 Human
Uniprot	NP_000881.3 Human P48544 Human
Product By Gene ID	3762
Alternate Names	Cardiac inward rectifier CIRKIR3.4 G protein-activated inward rectifier potassium channel 4 GIRK-4 GIRK4Kir3.4 Heart KATP channel Inward rectifier K(+) channel Kir3.4 inward rectifier K+ channel KIR3.4 IRK-4 KATP-1 KATP1cardiac ATP-sensitive potassium channel LQT13 Potassium channel, inwardly rectifying subfamily J member 5 potassium inwardly-rectifying channel, subfamily J, member 5