Species: Hu
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ELISA
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
G-protein regulated inward-rectifier potassium channels (GIRK) are part of a superfamily of inward-rectifier K+ channels. To date four GIRK subunits, designated GIRK1-4 (also designated Kir3.1-4), have been identified in mammals, and GIRK5 has been found in Xenopus oocytes. GIRK channels exist in vivo both as homotetramers and heterotetramers. GIRK channels are modulated by G-proteins; they are also modulated by phosphatidylinositol 4,5-bisphosphate, intracellular sodium, ethanol and mechanical stretch. GIRK1, 2 and 3 are highly abundant in brain. In general, neuronal GIRK channels are involved in the regulation of the excitability of neurons and may contribute to the resting potential.
Bioinformatics
Entrez |
Mouse Rat Human |
Uniprot |
Human Human |
Product By Gene ID |
3762 |
Alternate Names |
- Cardiac inward rectifier
- CIRKIR3.4
- G protein-activated inward rectifier potassium channel 4
- GIRK-4
- GIRK4Kir3.4
- Heart KATP channel
- Inward rectifier K(+) channel Kir3.4
- inward rectifier K+ channel KIR3.4
- IRK-4
- KATP-1
- KATP1cardiac ATP-sensitive potassium channel
- LQT13
- Potassium channel, inwardly rectifying subfamily J member 5
- potassium inwardly-rectifying channel, subfamily J, member 5
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