Kir3.4 Products

Description

G-protein regulated inward-rectifier potassium channels (GIRK) are part of a superfamily of inward-rectifier K+ channels. To date four GIRK subunits, designated GIRK1-4 (also designated Kir3.1-4), have been identified in mammals, and GIRK5 has been found in Xenopus oocytes. GIRK channels exist in vivo both as homotetramers and heterotetramers. GIRK channels are modulated by G-proteins; they are also modulated by phosphatidylinositol 4,5-bisphosphate, intracellular sodium, ethanol and mechanical stretch. GIRK1, 2 and 3 are highly abundant in brain. In general, neuronal GIRK channels are involved in the regulation of the excitability of neurons and may contribute to the resting potential.

Bioinformatics

Entrez	3762 Human 16521 Mouse 29173 Rat
Uniprot	P48544 Human NP_000881.3 Human
Product By Gene ID	3762
Alternate Names	KATP-1 Potassium channel, inwardly rectifying subfamily J member 5 IRK-4 Cardiac inward rectifier GIRK-4 inward rectifier K+ channel KIR3.4 Inward rectifier K(+) channel Kir3.4 G protein-activated inward rectifier potassium channel 4 Heart KATP channel KATP1cardiac ATP-sensitive potassium channel CIRKIR3.4 GIRK4Kir3.4 LQT13 potassium inwardly-rectifying channel, subfamily J, member 5

Diseases related to Kir3.4

Discover more about diseases related to Kir3.4.

Hyperaldosteronism
Adenoma
Conn Syndrome
Hypertensive Disease
Hyperplasia
Neoplasms
Tumors Of Adrenal Cortex
Adrenal Gland Neoplasms
Cardiac Fibrillation
Cardiac Arrhythmia
Adrenal Cortical Adenoma
Infarction
Myocardial Infarction
Atrial Fibrillation
Malignant Neoplasm Of Adrenal Cortex
Adrenal Hyperplasia
Pheochromocytoma
Endocrine Hypertension
Obesity
Carcinoma

Pathways for Kir3.4

View related products by pathway and learn more about each of the pathways below.

Pathogenesis
Membrane Depolarization
Cell Proliferation
Secretion
Aldosterone Secretion
Insulin Secretion
Transport
Regulation Of Signaling
Reverse Transcription
Translation
Nutrient Import
Lipid Homeostasis
Diestrus
Bioluminescence
Membrane Hyperpolarization
Dna Repair
Ion Transport
Cortisol Secretion
Energy Homeostasis
Regulation Of Aldosterone Secretion

Bioinformatics Tool for Kir3.4

Discover related pathways, diseases and genes to Kir3.4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.