Human. Immunogen has 98% identity with mouse, rat and bovine. Immunogen has 91% identity to Xenopus and Zebrafish.
Manufactured by Genomic Antibody Technology™. GAT FAQs
Alternate Names for JMJD6/PSR Antibody
bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Histone arginine demethylase JMJD6
JmjC domain-containing protein 6
jumonji domain containing 6
Jumonji domain-containing protein 6
Peptide-lysine 5-dioxygenase JMJD6
Jumonji domain containing 6 is a histone demethylating enzyme, which is active on arginine residues, but not lysines. Its activity destabilizes heterochromatin structures and activates gene expressions in euchromatin. In endothelial cells, the activity of JMJD6 is necessary for angiogenesis. If JMJD6 expression is reduced, the VEGF-receptor (Flt-1) is incorrectly spliced, leading to increased soluble Flt-1 which binds VEGF and PlGF and inhibits angiogenesis. JMJD6 also hydroxylates RNA splicing factors, and is important in embryonic differentiation. It most likely interacts specifically with single-stranded RNA, which may contribute to its early differentiation importance.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.