IRAK2 Antibody (600848) [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: WB
• Clone: 600848
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 750

IRAK2 Antibody (600848) [Alexa Fluor® 750] Summary

• Immunogen: E. coli-derived recombinant human IRAK2
  Ala2-Asn590
  Accession # O43187
• Specificity: Detects human IRAK2 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) IRAK1, 3, or 4 is observed. In Western blots, less than 25% cross-reactivity with rhIRAK1, 3, and 4 is observed.
• Source: N/A
• Isotype: IgG3
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IRAK2 Antibody (600848) [Alexa Fluor® 750]

• interleukin-1 receptor associated kinase-2
• interleukin-1 receptor-associated kinase 2
• interleukin-1 receptor-associated kinase-like 2
• IRAK2
• IRAK-2
• MGC150550

Background

IRAK2 is an approximately 75 kDa, 625 amino acid (aa) member of the IL-1 receptor-associated kinase (IRAK) family. The four IRAKs are ser/thr kinases that regulate signaling from Toll-like and IL-1 receptors. IRAKs contain N-terminal death domains and central kinase domains, but activity of the IRAK2 kinase domain is unknown. IRAK1 provides initial, and IRAK2 sustained, NFkB activation and proinflammatory cytokine production in macrophages, acting downstream of IRAK4. In the region used as an immunogen, human IRAK2 shares 69% and 70% amino acid identity with mouse and rat IRAK2, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • O43187()