IRAK2 Products

IRAK2 Antibody (JG36-23)
IRAK2 Antibody (JG36-23)
Species: Hu
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Monoclonal
IRAK2 Antibody (600848)
IRAK2 Antibody (600848)
Species: Hu
Applications: WB
Host: Mouse Monoclonal
Formulation Catalog # Availability Price  
IRAK2 Antibody
IRAK2 Antibody
Species: Hu, Mu
Applications: WB, ELISA, ICC/IF
Host: Rabbit Polyclonal
Recombinant Human IRAK2 GST ( ...
Recombinant Human IRAK2 GST (N-Ter...
Species: Hu
Applications: WB, ELISA, PA, PAGE, AP
IRAK2 Recombinant Protein Ant ...
IRAK2 Recombinant Protein Antigen
Species: Hu
Applications: AC
IRAK2 Antibody Blocking Pepti ...
IRAK2 Antibody Blocking Peptide
Species: Mu
Applications: AC


IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kB, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK2 (1). Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-kB activation. IRAKs also associate with Toll-like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-kB activation (2,3).Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory response. IRAK2 is expressed in a variety of human tissues.


Entrez Human
Uniprot Human
Product By Gene ID 3656
Alternate Names
  • interleukin-1 receptor-associated kinase-like 2
  • interleukin-1 receptor associated kinase-2
  • MGC150550
  • IRAK-2
  • interleukin-1 receptor-associated kinase 2

Research Areas for IRAK2

Find related products by research area and learn more about each of the different research areas below.

Innate Immunity
Protein Kinase
Signal Transduction

PTMs for IRAK2

Learn more about PTMs related to IRAK2.


Bioinformatics Tool for IRAK2

Discover related pathways, diseases and genes to IRAK2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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