IRAK2 Products

Antibodies
IRAK2 Antibody
IRAK2 Antibody
NB100-56447
Species: Hu, Mu
Applications: WB
Host: Rabbit Polyclonal
IRAK2 Antibody (600848)
IRAK2 Antibody (600848)
MAB6690
Species: Hu
Applications: WB
Host: Mouse Monoclonal
IRAK2 Antibody (1A6)
IRAK2 Antibody (1A6)
H00003656-M04
Species: Hu, Mu, Rt
Applications: WB, ELISA
Host: Mouse Monoclonal
Proteins
IRAK2 Partial Recombinant Pro ...
IRAK2 Partial Recombinant Protein
H00003656-Q01
Species: Hu
Applications: WB, ELISA, PA
IRAK2 Recombinant Protein Ant ...
IRAK2 Recombinant Protein Antigen
NBP2-38629PEP
Species: Hu
Applications: AC
IRAK2 Peptide
IRAK2 Peptide
NBP1-76424PEP
Species: Mu
Applications: AC
RNAi
IRAK2 RNAi
IRAK2 RNAi
H00003656-R02
Species: Hu

Description

IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kB, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK2 (1). Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-kB activation. IRAKs also associate with Toll-like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-kB activation (2,3).Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory response. IRAK2 is expressed in a variety of human tissues.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 3656
Alternate Names
  • interleukin-1 receptor-associated kinase-like 2
  • interleukin-1 receptor associated kinase-2
  • MGC150550
  • IRAK-2
  • interleukin-1 receptor-associated kinase 2

Research Areas for IRAK2

Find related products by research area and learn more about each of the different research areas below.

Immunology
Innate Immunity
Protein Kinase
Signal Transduction

PTMs for IRAK2

Learn more about PTMs related to IRAK2.

Phosphorylation
Methylation
Ubiquitination

Bioinformatics Tool for IRAK2

Discover related pathways, diseases and genes to IRAK2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.