Integrin beta 3/CD61 Antibody (VI-PL2) [FITC]

Images

 
Flow Cytometry: Integrin beta 3/CD61 Antibody (VI-PL2) [FITC] [NBP2-00247] - Staining of human platelets with Anti-Human CD41 PE and Mouse IgG1 K Isotype Control FITC (left) or Anti-Human CD61 (Integrin beta 3) FITC ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
VI-PL2
Clonality
Monoclonal
Host
Mouse
Conjugate
FITC
Concentration
5 mg/ml

Integrin beta 3/CD61 Antibody (VI-PL2) [FITC] Summary

Immunogen
The immunogen for this antibody was CD61.
Specificity
The VI-PL2 monoclonal antibody reacts with human CD61, also known as integrin beta 3 and GPIIIa.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
ITGB3
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
Application Notes
This VI-PL2 antibody has been tested by flow cytometric analysis of human peripheral blood platelets. This can be used at less than or equal to 0.125 ug per test. Cell number should be determined empirically but can range from 10^5to 10^8cells/test.

Reactivity Notes

This antibody is reactive to Human. This VI-PL2 antibody has also been shown to crossreact with canine and several non-human primate species, including baboon, rhesus, and cynomologus monkey.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS (pH 7.2) with 0.1% gelatin and 0.2% BSA
Preservative
0.09% Sodium Azide
Concentration
5 mg/ml
Purity
Protein A or G purified

Alternate Names for Integrin beta 3/CD61 Antibody (VI-PL2) [FITC]

  • CD61 antigen
  • CD61
  • GP3A
  • GP3Aplatelet glycoprotein IIIa
  • GPIIIA
  • GPIIIaintegrin beta-3
  • INGRB3
  • Integrin beta 3
  • integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
  • ITG B3
  • ITGB3
  • Platelet membrane glycoprotein IIIa

Background

The VI-PL2 monoclonal antibody reacts with human CD61, also known as integrin beta 3 and GPIIIa. CD61 is a 90-110 kDa member of the beta integrin family expressed by a wide variety of cells, including leukocytes, platelets, endothelial and smooth muscle cells. CD61 binds non-covalently with the alpha integrins CD41 and CD51, to form the alpha IIb beta3 (CD41/CD61) and alpha v beta3 (CD51/CD61) complexes. These alpha beta heterodimers are capable of mediating a variety of cellular responses including adhesion, trafficking, proliferaton and differentiation. The CD41/CD61 integrin has been shown to be involved in platelet aggregation, and binds to fibrinogen, von Willebrand Factor (vWF) and fibronectin. The CD51/CD61 integrin binds to matrix proteins including vitronectin, fibronectin, vWF and fibrinogen, and has been shown to have a strong role in modulating the migration and survival of angiogenic endothelial cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol ITGB3
Entrez