Hu, Mu, RtApplications:
WB, ICC/IF, IHC, IHC-PHost:
Hu, Mu, Rt, BvApplications:
WB, IA, IHC, IHC-Fr, IHC-P, IPHost:
WB, Flow, CyTOF-readyHost:
Platelet membrane glycoprotein Integrin beta-3 (GP IIIa) forms a Ca2+-dependent heterodimer complex with GP IIb. The GP IIb-IIIa complex constitutes the fibrinogen and fibronectin receptor on stimulated platelets. A biochemically and immunologically similar membrane glycoprotein complex is present on endothelial cells. Homology suggests that GP IIIa is a member of a family of cell-surface adhesion receptors. (1) Data provide further support for the key role of the cytoplasmic domain of the beta3 integrin in cell adhesion and suggest a potential role for the beta3C integrin subunit in modulating cell-matrix interactions (2). It has been demonstrated that the beta 3 subunit of alpha IIb beta 3 was phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Data suggest that tyrosine phosphorylation of an integrin beta subunit may be important in initiating outside-in signaling cascades by inducing association of signaling components directly with the integrin (3). be important in initiating outside-in signaling cascades by inducing association of signaling components directly with the integrin (3).
|Product By Gene ID
- ITG B3
- CD61 antigen
- GP3Aplatelet glycoprotein IIIa
- GPIIIaintegrin beta-3
- Platelet membrane glycoprotein IIIa
- integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Bioinformatics Tool for Integrin beta 3/CD61
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