Integrin beta 3/CD61 Antibody (VI-PL2)

Images

 
Flow Cytometry: Integrin beta 3/CD61 Antibody (VI-PL2) [NBP1-43394] - Analysis using the FITC conjugate of NBP1-43394. Staining of human platelets with Anti-Human CD41 PE and Mouse IgG1 K Isotype Control FITC (left) or ...read more
Flow Cytometry: Integrin beta 3/CD61 Antibody (VI-PL2) [NBP1-43394] - Staining of normal human peripheral blood platelets with 0.06 ug of Mouse IgG1 kappa Isotype Control Purified (NBP1-43319) (left) or 0.06 ug of ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, Func, IHC, IHC-Fr
Clone
VI-PL2
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Integrin beta 3/CD61 Antibody (VI-PL2) Summary

Immunogen
The immunogen for this antibody was CD61.
Specificity
The VI-PL2 monoclonal antibody reacts with human CD61, also known as integrin beta 3 and GPIIIa.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
ITGB3
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • Flow Cytometry <0.125 ug/10^6 cells
  • Functional
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
Application Notes
This VI-PL2 antibody has been tested by flow cytometric analysis of human peripheral blood platelets. This can be used at less than or equal to 0.125 ug per test. Cell number should be determined empirically but can range from 10^5to 10^8cells/test.

Reactivity Notes

This antibody is reactive to Human. This VI-PL2 antibody has also been shown to crossreact with canine and several non-human primate species, including baboon, rhesus, and cynomologus monkey.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Aqueous, may contain carrier protein/stabilizer.
Preservative
0.09% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein A or G purified

Alternate Names for Integrin beta 3/CD61 Antibody (VI-PL2)

  • CD61 antigen
  • CD61
  • GP3A
  • GP3Aplatelet glycoprotein IIIa
  • GPIIIA
  • GPIIIaintegrin beta-3
  • INGRB3
  • Integrin beta 3
  • integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
  • ITG B3
  • ITGB3
  • Platelet membrane glycoprotein IIIa

Background

The VI-PL2 monoclonal antibody reacts with human CD61, also known as integrin beta3 and GPIIIa. CD61 is a 90-110 kDa member of the /beta integrin family expressed by a wide variety of cells, including leukocytes, platelets, endothelial and smooth muscle cells. CD61 binds non-covalently with the alpha integrins CD41 and CD51, to form the alphaIIbbeta3 (CD41/CD61) and alphavbeta3 (CD51/CD61) complexes. Thesealphabeta heterodimers are capable of mediating a variety of cellular responses including adhesion, trafficking, proliferaton and differentiation. The CD41/CD61 integrin has been shown to be involved in platelet aggregation, and binds to fibrinogen, von Willebrand Factor (vWF) and fibronectin. The CD51/CD61 integrin binds to matrix proteins including vitronectin, fibronectin, vWF and fibrinogen, and has been shown to have a strong role in modulating the migration and survival of angiogenic endothelial cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NBP1-43394AF405
Alexa Fluor 488 Labeled NBP1-43394AF488
Alexa Fluor 647 Labeled NBP1-43394AF647
Alexa Fluor 700 Labeled NBP1-43394AF700
Allophycocyanin Labeled NBP1-43394APC
DyLight 350 Labeled NBP1-43394UV
DyLight 405 Labeled NBP1-43394V
DyLight 488 Labeled NBP1-43394G
DyLight 680 Labeled NBP1-43394FR
DyLight 755 Labeled NBP1-43394IR
FITC Labeled NBP2-00247
PE Labeled NBP1-43394PE
PerCP Labeled NBP1-43394PCP

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Bioinformatics

Gene Symbol ITGB3
Entrez
Uniprot