Integrin beta 2/CD18 Antibody (10E12) Summary
Purified recombinant fragment of CD18 expressed in E. Coli.
Test in a species/application not listed above to receive a full credit towards a future purchase.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.03% Sodium Azide
This product is unpurified. The exact concentration of antibody is not quantifiable.
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.
Alternate Names for Integrin beta 2/CD18 Antibody (10E12)
- 959 beta subunit precursor)10
- CD18 antigen
- CD18beta 2
- cell surface adhesion glycoprotein (LFA-1
- integrin beta-2
- integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1;macrophage antigen 1 (mac-1) beta subunit)
- integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
- leukocyte cell adhesion molecule CD18
- leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C
- LFA-1 beta
- MAC-1 beta
- p150,95 beta
CD18, integrin b2 subunit, forms heterodimers with four types of CD11 molecule to constitute leukocyte (b2) integrins: aLb2 (CD11a/CD18, LFA-1), aMb2 (CD11b/CD18, Mac-1, CR3), aXb2 (CD11c/CD18) and aDb2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits. These integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1; severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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FAQs for Integrin beta 2/CD18 Antibody (NBP1-47440). (Showing 1 - 1 of 1 FAQ).
Is this antibody (Anti-CD18 antibody 10E12) blocking the CD18 function?
- Unfortunately, our Integrin beta 2/CD18 antibody has not yet been tested in a blocking/neutralizing assay. We do not have any information available on this antibody's use in that specific application and cannot guarantee its performance in it.
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