Integrin alpha L/CD11a Antibody

Images

 
Western Blot: Integrin alpha L/CD11a Antibody [NBP1-51967] - (0.5ug/ml) staining of Human Spleen lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Immunohistochemistry-Paraffin: Integrin alpha L/CD11a Antibody [NBP1-51967] - (2ug/ml) staining of paraffin embedded Human Lymph Node. Microwaved antigen retrieval with citrate buffer pH 6, HRP-staining.
Immunohistochemistry-Paraffin: Integrin alpha L/CD11a Antibody [NBP1-51967] - (3.8ug/ml) Staining of paraffin embedded Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IHC-P, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

Integrin alpha L/CD11a Antibody Summary

Immunogen
Peptide with sequence C-YQVRIQPSIHDHN corresponding to internal region according to NP_002200.2, NP_001107852.1.
Epitope
C-YQVRIQPSIHDHN
Specificity
This antibody is expected to recognize both reported isoforms (NP_002200.2; NP_001107852.1).
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
ITGAL
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.5-2 ug/ml
  • Immunohistochemistry 4 - 6 ug/ml
  • Immunohistochemistry-Paraffin 4-6 ug/ml
  • Peptide ELISA 1:16000
Application Notes
WB: Approx. 200 kDa band observed in human spleen and tonsil lysates (calculated MW of 129 kDa band according to NP_002200.2). The observed molecular weight corresponds to earlier findings with different antibodies from other sources. IHC-P: Human liver shows selected staining of cells within aggregated splenocytes of the white pulp.
Positive Control
Blood Leukocyte Lysate (NB820-59174)
Appendix Lysate (NB820-59172)
Lymph Node Lysate (NB820-59242)
Publications
Read Publication using NBP1-51967.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Canine.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Integrin alpha L/CD11a Antibody

  • CD11 antigen-like family member A
  • CD11a antigen
  • CD11a
  • CD11Aantigen CD11A (p180), lymphocyte function-associated antigen 1, alphapolypeptide
  • Integrin alpha L
  • integrin alpha-L
  • integrin gene promoter
  • integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen1; alpha polypeptide)
  • ITGAL
  • Leukocyte adhesion glycoprotein LFA-1 alpha chain
  • Leukocyte function-associated molecule 1 alpha chain
  • LFA-1 alpha
  • LFA-1
  • LFA1A
  • LFA-1A
  • Ly-15
  • Ly-21
  • lymphocyte function-associated antigen 1

Background

CD11a is a 180 kD glycoprotein, also known as alpha-L integrin, LFA-1 alpha, Ly-15, or Ly-21. It is a member of the integrin family, primarily expressed on lymphocytes, monocytes/macrophages, and granulocytes. In association with CD18, the CD11a/CD18 complex forms LFA-1. CD11a plays an important role in intercellular adhesion and costimulation by binding its ligands, ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50). The 2D7 antibody can block CD11a-mediated cellular adhesion.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol ITGAL
Entrez
Uniprot