Integrin alpha 5/CD49e Antibody (SNAKA52) - BSA Free

• Reactivity: Hu
• Applications: ELISA, Func, B/N
• Clone: SNAKA52
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

Integrin alpha 5/CD49e Antibody (SNAKA52) - BSA Free Summary

• Description: Novus Biologicals Mouse Integrin alpha 5/CD49e Antibody (SNAKA52) - BSA Free (NBP2-50147) is a monoclonal antibody validated for use in ELISA. Anti-Integrin alpha 5/CD49e Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: alpha5 beta1 purified from human placenta.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Mouse
• Gene: ITGA5
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Block/Neutralize
  • ELISA 1:100 - 1:2000
  • Functional
• Application Notes: Positive control(s): HeLa cells. Use in blocking/neutralizing reported in scientific literature (PMID: 27484800).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Protein A purified

Alternate Names for Integrin alpha 5/CD49e Antibody (SNAKA52) - BSA Free

• CD49 antigen-like family member E
• CD49e antigen
• CD49e
• Fibronectin receptor subunit alpha
• fibronectin receptor, alpha subunit
• FNRAVLA5A
• Integrin alpha 5
• integrin alpha-5
• Integrin alpha-F
• integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
• ITGA5
• very late activation protein 5, alpha subunit
• VLA-5 alpha
• VLA-5

Background

CD49e is a type I integral membrane glycoprotein, known as alpha5 integrin, VLA-5 alpha chain. It forms noncovalent heterodimer with integrin beta1 (CD29). CD49e contains two disulfide-linked subunits of 135 kDa and 24 kDa, and is mainly expressed on thymocytes, activated lymphocytes, endothelial cells, osteoblasts, melanoma, and some myeloid leukemia cells. CD49e/CD29 complex binds to fibronection and neural adhesion molecule L1. It mediates monocytes migration, involves in the regulation of cells survival and apoptosis, and co-stimulates T cell activation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Integrin alpha 5/CD49e Antibody (NBP2-50147)(1)

Publication using NBP2-50147

• Mould A, Askari J, Byron A et al. Ligand-induced Epitope Masking: DISSOCIATION OF INTEGRIN a5b1-FIBRONECTIN COMPLEXES ONLY BY MONOCLONAL ANTIBODIES WITH AN ALLOSTERIC MODE OF ACTION. J Biol Chem. [PMID: 27484800] (B/N, Human)

Bioinformatics

• Gene Symbol: ITGA5