Integrin alpha 3/CD49c Antibody (IA3) [Alexa Fluor® 488] Summary
Human milk epithelial cell line
Detects human Integrin alpha 3/CD49c.
Test in a species/application not listed above to receive a full credit towards a future purchase.
- Flow Cytometry 0.25-1 ug/10^6 cells
Flow Cytometry: Please use 0.25-1 ug of conjugated antibody per 10e6 cells.
Packaging, Storage & Formulations
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
0.09% Sodium Azide
Please see the vial label for concentration. If unlisted please contact technical services.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Integrin alpha 3/CD49c Antibody (IA3) [Alexa Fluor® 488]
- antigen identified by monoclonal J143
- CD49 antigen-like family member C
- CD49c antigen
- Galactoprotein B3
- Integrin alpha 3
- integrin alpha-3
- integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
- very late activation protein 3 receptor, alpha-3 subunit
- VLA-3 subunit alpha
(Very Late Antigen 3) is a member of the integrin family, beta 1 subfamily,
of cell membrane adhesion molecules (1-3). Integrins are
nondisulfide-linked transmembrane (TM) heterodimers that contain an alpha -
and beta -subunit (1). VLA-3 is composed of an alpha 3 and beta 1 subunit. The
alpha 3/CD49c subunit is a 130-150 kDa type I TM glycoprotein. It only
associates with the beta 1 integrin subunit. It is synthesized as a 1051 amino acid (aa) precursor that undergoes proteolytic cleavage to
generate a disulfide-linked 110 kDa, 843 aa extracellular heavy chain
and a 30 kDa, 176 aa TM/cytoplasmic light chain (1, 4, 5, 6). The heavy
chain contains seven 60 aa repeats that fold into a propeller-like
structure (7). Sequences involving the first three repeats are
associated with ligand binding (1). The light chain has two cytoplasmic
alternate splice forms. The A form cytoplasmic domain is 52 aa, while
the B form cytoplasmic domain is 37 aa (5). Human alpha 3 heavy chain is 88% aa identical to mouse heavy chain. VLA-3 is known to bind fibronectin, collagen, and laminin-1, 5, 8, 10 and 11 (1). It also binds tetraspanins such as CD9,
CD63 and CD151. CD151 binding may actually stabilize VLA-3, enabling it
to bind to additional factors (8).
- Tsuji, T. et al. (2004) J. Membr. Biol. 200:115.
- Gu, J. and N. Taniguchi (2004) Glycoconj. J. 21:9.
- Kreidberg, J.A. (2000) Curr. Opin. Cell Biol. 12:548.
- Takada, Y. et al. (1991) J. Cell. Biol. 115:257.
- de Melker, A.A. et al. (1997) Lab. Invest. 76:547.
- Krokhin, O.V. et al. (2003) Biochemistry 42:12950.
- Springer, T.A. (2002) Curr. Opin. Struct. Biol. 12:802.
- Nishiuchi, R. et al. (2005) Proc. Natl. Acad. Sci. USA 102:1939.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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