Integrin alpha V beta 5 Antibody (P5H9)

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Integrin alpha V beta 5 was detected in immersion fixed HT1080 human fibrosarcoma cell line using Human Integrin alpha V beta 5 Monoclonal Antibody (Catalog # MAB2528) at 10 µg/mL for 3 hours at room temperature. ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, IP, B/N, CyTOF-ready, ICC/IF
Clone
P5H9
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Integrin alpha V beta 5 Antibody (P5H9) Summary

Immunogen
HT1080 human fibrosarcoma cell line
Specificity
Detects human Integrin alpha V beta 5. Recognizes the human Integrin alpha V beta 5 heterodimer and does not recognize the alpha V subunit in association with any other beta subunits.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ITGAV
Purity
Protein A or G purified from hybridoma culture supernatant
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 2.5 ug/10^6 cells
  • Immunoprecipitation
  • Adhesion Blockade
  • CyTOF-ready
  • Immunocytochemistry 8-25 ug/mL
Publications
Read Publications using
MAB2528 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A or G purified from hybridoma culture supernatant
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Integrin alpha V beta 5 Antibody (P5H9)

  • CD51
  • Integrin alpha V beta 5
  • integrin subunit alpha V
  • ITGAV
  • MSK8
  • VNRA
  • VTNR

Background

Integrins are heterodimeric receptors comprised of an alpha and a beta subunit. Integrin alpha V (CD51) associates with several different beta subunits, but Integrin beta 5 associates exclusively with the alpha V subunit. Integrin alpha V beta 5, also known as Integrin alpha V beta S and Integrin alpha V beta 3B, is a transmembrane heterodimeric protein that functions as a receptor for Vitronectin. It is expressed on hepatoma cells, fibroblasts and carcinoma cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Integrin alpha V beta 5 Antibody (MAB2528)(11)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 4 applications: Flow Cytometry, ICC, IHC, Neutralization.


Filter By Application
Flow Cytometry
(6)
ICC
(1)
IHC
(1)
Neutralization
(3)
All Applications
Filter By Species
Human
(11)
All Species
Showing Publications 1 - 10 of 11. Show All 11 Publications.
Publications using MAB2528 Applications Species
M Garcia-Mou, N Martinez-V, M Gonzalez-H, L Marrodán, M Cascallo, R Alemany, A Patiño-Gar, MM Alonso The oncolytic adenovirus VCN-01 promotes anti-tumor effect in primitive neuroectodermal tumor models Sci Rep, 2019;9(1):14368. 2019 [PMID: 31591461] (Flow Cytometry, Human) Flow Cytometry Human
E Peterman, P Gibieža, J Schafer, VA Skeberdis, A Kaupinis, M Valius, X Heiligenst, I Hurbain, G Raposo, R Prekeris The post-abscission midbody is an intracellular signaling organelle that regulates cell proliferation Nat Commun, 2019;10(1):3181. 2019 [PMID: 31320617] (ICC, Human) ICC Human
H Huang, Y Dong, Y Zhang, D Ru, Z Wu, J Zhang, M Shen, Y Duan, Y Sun GSH-sensitive Pt(IV) prodrug-loaded phase-transitional nanoparticles with a hybrid lipid-polymer shell for precise theranostics against ovarian cancer Theranostics, 2019;9(4):1047-1065. 2019 [PMID: 30867815] (Flow Cytometry, Human) Flow Cytometry Human
J Wei, A Marisetty, B Schrand, K Gabrusiewi, Y Hashimoto, M Ott, Z Grami, LY Kong, X Ling, HG Caruso, S Zhou, YA Wang, GN Fuller, JT Huse, E Gilboa, N Kang, X Huang, R Verhaak, S Li, AB Heimberger Osteopontin mediates glioblastoma-associated macrophage infiltration and is a therapeutic target J. Clin. Invest., 2018;0(0):. 2018 [PMID: 30307407] (Neutralization, Human) Neutralization Human
K Miyano, H Cabral, Y Miura, Y Matsumoto, Y Mochida, H Kinoh, K Iwata, O Nagano, H Saya, N Nishiyama, K Kataoka, T Yamasoba cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells J Control Release, 2017;0(0):. 2017 [PMID: 28666729] (Flow Cytometry, Human) Flow Cytometry Human
ME Burgett, JD Lathia, P Roth, AS Nowacki, DS Galileo, E Pugacheva, P Huang, A Vasanji, M Li, T Byzova, T Mikkelsen, S Bao, JN Rich, M Weller, CL Gladson Direct contact with perivascular tumor cells enhances integrin �v?3 signaling and migration of endothelial cells Oncotarget, 2016;7(28):43852-43867. 2016 [PMID: 27270311] (Neutralization, Human) Neutralization Human
Shen Y, Yang F, Wang H, Cai Z, Xu Y, Zhao A, Su Y, Zhang G, Zhu S Arg-Gly-Asp (RGD)-Modified E1A/E1B Double Mutant Adenovirus Enhances Antitumor Activity in Prostate Cancer Cells In Vitro and in Mice. PLoS ONE, 2016;11(1):e0147173. 2016 [PMID: 26799485] (Flow Cytometry, Human) Flow Cytometry Human
Dixon K, O'Flynn J, van der Kooij S, van Kooten C Phagocytosis of apoptotic or necrotic cells differentially regulates the transcriptional expression of IL-12 family members in dendritic cells. J Leukoc Biol, 2014;96(2):313-24. 2014 [PMID: 24782489] (Flow Cytometry, Human) Flow Cytometry Human
Mathieu M, Iampietro M, Chuchana P, Guerit D, Djouad F, Noel D, Jorgensen C Involvement of angiopoietin-like 4 in matrix remodeling during chondrogenic differentiation of mesenchymal stem cells. J Biol Chem, 2014;289(12):8402-12. 2014 [PMID: 24505142] (IHC, Human) IHC Human
Wang L, Pedroja BS, Meyers EE, Garcia AL, Twining SS, Bernstein AM Degradation of internalized alphaVbeta5 integrin is controlled by uPAR bound uPA: effect on beta1 integrin activity and alpha-SMA stress fiber assembly. PLoS ONE, 2012;7(3):e33915. 2012 [PMID: 22470492] (Neutralization, Human) Neutralization Human
Show All 11 Publications.

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 FAB2528U
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Alexa Fluor 647 FAB2528R
Alexa Fluor 700 FAB2528N
Alexa Fluor 750 FAB2528S
Allophycocyanin FAB2528A
Phycoerythrin FAB2528P

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Gene Symbol ITGAV
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