IMPA1 Antibody (984603) [Alexa Fluor® 350]

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clone: 984603
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 350

IMPA1 Antibody (984603) [Alexa Fluor® 350] Summary

• Immunogen: Synthetic peptide containing human IMPA/IMPA1 Peptide
  Accession # P29218
• Specificity: Detects human IMPA/IMPA1 Peptide in direct ELISAs. Detects human, mouse, and rat IMPA/IMPA1 in Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IMPA1 Antibody (984603) [Alexa Fluor® 350]

• EC 3.1.3.25
• IMP 1
• IMP
• IMP1
• IMPA
• IMPA1
• IMPase 1
• inositol monophosphatase 1
• inositol(myo)-1(or 4)-monophosphatase 1
• Inositol-1(or 4)-monophosphatase 1
• Lithium-sensitive myo-inositol monophosphatase A1
• MRT59
• Myo-Inositol Monophosphatase 1

Background

IMPA-1/inositol(myo)-1(or 4)-monophosphatase 1 is a ubiquitous enzyme with broad specificity, which is responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides. IMPA-1 dephosphorylates myo-inositol monophosphatate to modulate intracellular signal transduction. IMPA-1 forms homodimers, and is abundantly expressed in brain. The magnesium-dependent phosphatase activity is inhibited by lithium, thereby depressing myo-inositol production, which may explain the anti-depressive and anti-manic effects of lithium therapy in bipolar disorder.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.