IL18R1 Antibody (B-E43) - Azide and BSA Free

Flow Cytometry: IL18R1 Antibody (B-E43) [NBP3-14586] - A typical staining pattern with B-E43 monoclonal antibody on U937 cell line.

• Reactivity: Hu
• Applications: ELISA, Flow, Func
• Clone: B-E43
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: Azide and BSA Free
• Concentration: 1 mg/ml

IL18R1 Antibody (B-E43) - Azide and BSA Free Summary

• Description: Stable at 4C for 12 months.
  
  Hybridoma: Myeloma X63/AG.8653 x Balb/c spleen cells
• Immunogen: Recombinant human IL18R1
• Specificity: recognizes IL18R1, a 63 kDa protein. Cross-reacts with mouse CDw218a protein in cytometry.
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: IL18R1
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Flow Cytometry
  • Functional
• Application Notes: Biological Activity: Inhibits human IFN-gamma secretion induced by IL-18 stimulated cells

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS. Sterile-filtered through 0.22 um.
• Preservative: No Preservative
• Concentration: 1 mg/ml
• Purity: Affinity purified

Alternate Names for IL18R1 Antibody (B-E43) - Azide and BSA Free

• CD218 antigen-like family member A
• CD218a antigen
• CD218a
• CDw218a
• cytokine receptor
• IL-18R1
• IL-18R-1
• IL1R-rp
• IL1RRPIL1 receptor-related protein
• IL-1RrpIL18RA
• interleukin 18 receptor 1
• interleukin-18 receptor 1

Background

IL-18 receptor is composed of an alpha and a beta subunit that combine to form a high affinity receptor for IL-18. IL-18 receptor alpha chain, also known as CDw218a, is a 75-80 kD type I transmembrane protein. It is expressed on NK cells, neutrophils, endothelial cells, and subsets of T and B cells. The expression of CDw218a on lymphocytes is upregulated after activation. The interaction of IL-18 and IL-18 receptor has been reported to be implicated in promotion of Th1 cytokine production and atherogenesis. The H44 antibody is specific for IL-18 receptor alpha chain and has been reported to block IL-18 binding to the receptor and to be useful for the identification of IL-18 receptor by flow cytometry and IHC.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: IL18R1