Human IL-18 BPa DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human IL-18 BPa DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: IL18BP

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IL-18 BPa DuoSet ELISA, 15 Plate

• IL18 BPa
• IL-18 BPa
• IL18BP
• IL-18BP
• IL18BPa
• interleukin 18 binding protein
• interleukin-18-binding protein
• MC51L-53L-54L homolog gene product
• Tadekinig-alfa

Background

Interleukin 18 binding proteins are secreted glycoproteins which antagonize IL-18 activity by binding IL-18 and blocking its biological activity. Alternative splicing of the IL-18 BP gene produces at least four isoforms that differ in affinity for IL-18. The IL-18 BP isoforms a and c each contain one immunoglobulin (Ig)-like C2-type domain while isoforms b and d lack a complete Ig-like domain.

Publications for IL-18 BPa/IL18BP (DY119)(22)

Publications using DY119

• Papatheodorou, I;Blažková, G;Bosáková, V;Tomášiková, Z;Spearing, E;Klieber, R;Ostašov, P;Štíchová, J;Dvon?ová, M;Mýtniková, A;Emmer, J;Bendí?ková, K;Tomáš, T;Šrámek, V;Kolovos, P;Holubová, M;Helán, M;Vlková, M;Fri?, J;Hortová-Kohoutková, M; Redefining the role of IL-18 in post-surgical recovery and sepsis: a key mediator of inflammation resolution Journal of translational medicine 2025-07-02 [PMID: 40604830] (Human)
• Cecrdlova, E;Krupickova, L;Fialova, M;Novotny, M;Tichanek, F;Svachova, V;Mezerova, K;Viklicky, O;Striz, I; Insights into IL-1 family cytokines in kidney allograft transplantation: IL-18BP and free IL-18 as emerging biomarkers Cytokine 2024-05-25 [PMID: 38801805] (Human)
• KCG Manfrere, MP Torrealba, FM Ferreira, ESA de Sousa, D Miyashiro, FME Teixeira, RWA Custódio, HI Nakaya, YAL Ramos, MN Sotto, A Woetmann, N Ødum, AJDS Duarte, JA Sanches, MN Sato Imbalanced IL-1B and IL-18 Expression in S�zary Syndrome International Journal of Molecular Sciences, 2023-02-28;24(5):. 2023-02-28 [PMID: 36902104] (Human)
• G Hjell, A Szabo, L Mørch-John, R Holst, N Tesli, C Bell, T Fischer-Vi, MCF Werner, SH Lunding, MBEG Ormerod, IT Johansen, I Dieset, S Djurovic, I Melle, T Ueland, OA Andreassen, NE Steen, UK Haukvik Interleukin-18 signaling system links to agitation in severe mental disorders Psychoneuroendocrinology, 2022-03-12;140(0):105721. 2022-03-12 [PMID: 35301151] (Human)
• A Radujkovic, L Kordelas, R Bogdanov, C Müller-Tid, DW Beelen, P Dreger, T Luft Interleukin-18 and Hematopoietic Recovery after Allogeneic Stem Cell Transplantation Cancers (Basel), 2020-09-28;12(10):. 2020-09-28 [PMID: 32998441] (Human)
• W Huang, NJ Queen, TB McMurphy, S Ali, L Cao Adipose PTEN regulates adult adipose tissue homeostasis and redistribution via a PTEN-leptin-sympathetic loop Mol Metab, 2019-09-28;30(0):48-60. 2019-09-28 [PMID: 31767180] (Mouse)
• K Wedervang-, S Friis, V Lonning, RE Smelror, C Johannesse, EJ Reponen, SH Lyngstad, T Lekva, P Aukrust, T Ueland, OA Andreassen, I Agartz, AM Myhre Increased interleukin 18 activity in adolescents with early-onset psychosis is associated with cortisol and depressive symptoms Psychoneuroendocrinology, 2019-11-14;0(0):104513. 2019-11-14 [PMID: 31761332] (Human)
• RE Elphinston, AM Weckman, CR McDonald, V Tran, K Zhong, M Madanitsa, L Kalilani-P, C Khairallah, SM Taylor, SR Meshnick, V Mwapasa, FO Ter Kuile, AL Conroy, KC Kain Early malaria infection, dysregulation of angiogenesis, metabolism and inflammation across pregnancy, and risk of preterm birth in Malawi: A cohort study PLoS Med., 2019-10-01;16(10):e1002914. 2019-10-01 [PMID: 31574087] (Human)
• CR McDonald, AM Weckman, AL Conroy, P Olwoch, P Natureeba, MR Kamya, DV Havlir, G Dorsey, KC Kain Systemic inflammation is associated with malaria and preterm birth in women living with HIV on antiretrovirals and co-trimoxazole Sci Rep, 2019-05-01;9(1):6758. 2019-05-01 [PMID: 31043691] (Human)
• T Keeley, A Kirov, WY Koh, V Demambro, I Bergquist, J Cotter, P Caradonna, ME Siviski, B Best, T Henderson, CJ Rosen, L Liaw, I Prudovsky, DJ Small Resistance to visceral obesity is associated with increased locomotion in mice expressing an endothelial cell-specific fibroblast growth factor 1 transgene Physiol Rep, 2019-04-01;7(7):e14034. 2019-04-01 [PMID: 30972920] (Human)
• A Radujkovic, H Dai, L Kordelas, D Beelen, SP Rachakonda, C Müller-Tid, R Kumar, P Dreger, T Luft Asymmetric dimethylarginine serum levels are associated with early mortality after allogeneic stem cell transplantation Haematologica, 2018-12-04;0(0):. 2018-12-04 [PMID: 30514796] (Human)
• C Baumeier, L Schlüter, S Saussentha, T Laeger, M Rödiger, SA Alaze, L Fritsche, HU Häring, N Stefan, A Fritsche, RW Schwenk, A Schürmann Elevated hepatic DPP4 activity promotes insulin resistance and non-alcoholic fatty liver disease Mol Metab, 2017-08-04;6(10):1254-1263. 2017-08-04 [PMID: 29031724] (Mouse)
• LM Scott, AH Bryant, A Rees, B Down, RH Jones, CA Thornton Production and regulation of interleukin-1 family cytokines at the materno-fetal interface Cytokine, 2017-07-13;0(0):. 2017-07-13 [PMID: 28712670] (Human)
• McDonald C, Darling A, Conroy A, Tran V, Cabrera A, Liles W, Wang M, Aboud S, Urassa W, Fawzi W, Kain K Inflammatory and Angiogenic Factors at Mid-Pregnancy Are Associated with Spontaneous Preterm Birth in a Cohort of Tanzanian Women. PLoS ONE, 2015-08-06;10(8):e0134619. 2015-08-06 [PMID: 26247200] (Human)
• Richards , Kathryn, Doble , Rosella, Wasson , Christop, Haider , Mohammed, Blair , G Eric, Wittmann , Miriam, Macdonald , Andrew Human papillomavirus E7 oncoprotein increases production of the anti-inflammatory interleukin-18 binding protein in keratinocytes. J Virol, 2014-01-29;88(8):4173-9. 2014-01-29 [PMID: 24478434] (Human)
• Conroy A, Gelvez M, Hawkes M, Rajwans N, Liles W, Villar-Centeno L, Kain K Host biomarkers distinguish dengue from leptospirosis in Colombia: a case-control study. BMC Infect Dis, 2014-01-20;14(0):35. 2014-01-20 [PMID: 24444080] (Human)
• Tu T, Kim C, Kang J, Nam-Goong I, Nam C, Kim E, Kim Y, Choi J, Kawada T, Goto T, Park T, Yoon Park J, Choi M, Yu R Levels of 4-1BB transcripts and soluble 4-1BB protein are elevated in the adipose tissue of human obese subjects and are associated with inflammatory and metabolic parameters. Int J Obes (Lond), 2013-11-27;38(8):1075-82. 2013-11-27 [PMID: 24281650] (Mouse)
• Boyd A, Bennuru S, Wang Y, Sanprasert V, Law M, Chaussabel D, Nutman T, Semnani R Quiescent innate response to infective filariae by human Langerhans cells suggests a strategy of immune evasion. Infect Immun, 2013-02-19;81(5):1420-9. 2013-02-19 [PMID: 23429540] (Human)
• Impact of vitamin D supplementation on markers of inflammation in adults with cystic fibrosis hospitalized for a pulmonary exacerbation. Eur J Clin Nutr, 2012-07-18;66(9):1072-4. 2012-07-18 [PMID: 22805498] (Human)
• Zhang H, Hile KL, Asanuma H IL-18 mediates proapoptotic signaling in renal tubular cells through a Fas ligand-dependent mechanism. Am. J. Physiol. Renal Physiol., 2011-04-20;301(1):F171-8. 2011-04-20 [PMID: 21511702] (Human)
• Reeves EP, Williamson M, Byrne B, Bergin DA, Smith SG, Greally P, O'Kennedy R, O'Neill SJ, McElvaney NG IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis. J. Immunol., 2009-12-21;184(3):1642-52. 2009-12-21 [PMID: 20026745] (Human)
• De Jager W, Vastert SJ, Beekman JM, Wulffraat NM, Kuis W, Coffer PJ, Prakken BJ Defective phosphorylation of interleukin-18 receptor beta causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis. Arthritis Rheum., 2009-09-01;60(9):2782-93. 2009-09-01 [PMID: 19714583] (Human)

FAQs for IL-18 BPa/IL18BP (DY119). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: IL18BP