IL-21R Antibody

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, CyTOF-ready
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Catalog# & Conjugate Size Price
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Catalog# & Formulation Size Price

IL-21R Antibody Summary

Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human IL‑21 R Subunit
Cys20-Pro236
Accession # Q9HBE5
Specificity
Detects human IL‑21 R Subunit in direct ELISAs and Western blots. In direct ELISAs, approximately 45% cross-reactivity with recombinant mouse IL‑21 R is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
IL21R
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.1 ug/mL
  • Flow Cytometry 2.5 ug/10^6 cells
  • CyTOF-ready
Publications
Read Publications using
AF991 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Immunogen affinity purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IL-21R Antibody

  • CD360 antigen
  • CD360
  • IL-21 R
  • IL-21 receptor
  • IL21R
  • IL-21R
  • interleukin 21 receptor
  • interleukin-21 receptor
  • MGC10967
  • NILR
  • Novel interleukin receptor

Background

Interleukin-21 (IL-21) and its receptor play an important role in the regulation of the immune system. IL-21 R, also called NILR (novel interleukin receptor), is a type I cytokine receptor with 4 conserved cysteine residues and an extracellular WSXWS motif. It is most closely related to IL-2 R beta, IL-4 R alpha  and IL-9 R. The gene for human IL-21 R has been mapped to chromosome 16p12. Human IL-21 R is a 538 amino acid (aa) residue type I transmembrane protein with a 19 aa signal peptide, a 217 aa extracellular domain, a 19 aa transmembrane domain and a 283 aa cytoplasmic domain. IL-21 R is expressed on lymphoid tissues, peripheral B cells and cell lines of T, B and NK lineage. The common gamma  chain ( gamma c) is required for IL-21 R signaling. The IL-21/IL-21 R interaction appears to play an important role in B and T cell proliferation after antigen stimulation and NK cell maturation.

  1. Parrish-Novak, et al. (2000) Nature 408:57.
  2. Ozaki, K. et al. (2000) Proc. Natl. Acad. Sci. USA 97:11439.
  3. Dumoutier, L. et al. (2000) Proc. Natl. Acad. Sci. USA 97:10144.
  4. Asao, H. et al. (2001) J. Immunol. 167:1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for IL-21R Antibody (AF991)(6)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: Flow Cytometry, Functional Assay, Western Blot.


Filter By Application
Flow Cytometry
(2)
Functional Assay
(1)
Western Blot
(3)
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Filter By Species
Human
(6)
All Species
Showing Publications 1 - 6 of 6.
Publications using AF991 Applications Species
Kaltenmeier C, Gawanbacht A, Beyer T, Lindner S, Trzaska T, van der Merwe J, Harter G, Gruner B, Fabricius D, Lotfi R, Schwarz K, Schutz C, Honig M, Schulz A, Kern P, Bommer M, Schrezenmeier H, Kirchhoff F, Jahrsdorfer B CD4+ T cell-derived IL-21 and deprivation of CD40 signaling favor the in vivo development of granzyme B-expressing regulatory B cells in HIV patients. J Immunol, 2015;194(8):3768-77. 2015 [PMID: 25780036] (Functional Assay, Human) Functional Assay Human
de Totero D, Capaia M, Fabbi M, Croce M, Meazza R, Cutrona G, Zupo S, Loiacono F, Truini M, Ferrarini M, Ferrini S Heterogeneous expression and function of IL-21R and susceptibility to IL-21-mediated apoptosis in follicular lymphoma cells. Exp. Hematol., 2010;38(5):373-83. 2010 [PMID: 20193734] (Western Blot, Human) Western Blot Human
Ansen S, Butler MO, Berezovskaya A, Murray AP, Stevenson K, Nadler LM, Hirano N Dissociation of its opposing immunologic effects is critical for the optimization of antitumor CD8+ T-cell responses induced by interleukin 21. Clin. Cancer Res., 2008;14(19):6125-36. 2008 [PMID: 18829491] (Flow Cytometry, Human) Flow Cytometry Human
Baan CC, Balk AH, Dijke IE, Korevaar SS, Peeters AM, de Kuiper RP, Klepper M, Zondervan PE, Maat LA, Weimar W Interleukin-21: an interleukin-2 dependent player in rejection processes. Transplantation, 2007;83(11):1485-92. 2007 [PMID: 17565322] (Flow Cytometry, Human) Flow Cytometry Human
Caruso R, Fina D, Peluso I, Fantini MC, Tosti C, Del Vecchio Blanco G, Paoluzi OA, Caprioli F, Andrei F, Stolfi C, Romano M, Ricci V, MacDonald TT, Pallone F, Monteleone G IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis. J. Immunol., 2007;178(9):5957-65. 2007 [PMID: 17442980] (Western Blot, Human) Western Blot Human
Jungel A, Distler JH, Kurowska-Stolarska M, Seemayer CA, Seibl R, Forster A, Michel BA, Gay RE, Emmrich F, Gay S, Distler O Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis. Arthritis Rheum., 2004;50(5):1468-76. 2004 [PMID: 15146416] (Western Blot, Human) Western Blot Human

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Product General Protocols

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Biotin BAF991

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Bioinformatics

Gene Symbol IL21R
Uniprot