Recombinant Mouse IL-21 Protein

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications PAGE, HPLC
Concentration
Lyoph

Order Details

Recombinant Mouse IL-21 Protein Summary

Description
Recombinant bioactive protein containing 130 amino acids for Mouse IL-21

Source:E. coli
Amino Acid Sequence:(Q9ES17)

Details of Functionality
The bioactivity is determined by a dose-dependent proliferation of lymphocytes co-stimulated with anti-CD3E and is typically 2-50 ng/ml.
Source
E. coli
Protein/Peptide Type
Biologically Active Protein
Gene
IL21
Purity
>95%, by SDS-PAGE
Endotoxin Note
<0.01 ng/ug

Applications/Dilutions

Theoretical MW
15.095 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at -20 to -80C. Avoid freeze-thaw cycles.
Buffer
Lyophilized from 20 mM NaHCO3, pH 8.5
Concentration
Lyoph
Purity
>95%, by SDS-PAGE
Reconstitution Instructions
When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile H2O to a concentration of 0.1 mg/ml, which can be further diluted into other aqueous solutions.

Alternate Names for Recombinant Mouse IL-21 Protein

  • IL21
  • IL-21
  • IL-21Za11interleukin-21
  • interleukin 21
  • interleukin-21 isoform

Background

Mouse Interleukin-21 (m-IL-21), expressed by activated CD4(+) T cells, is the newest member of the common gamma-chain family of cytokines, which also includes IL-2, IL-4, IL-7, IL-9, and IL-13. Its private receptor, IL-21R, is expressed on T, B, and NK cells. Within the B cell lineage, IL-21 regulates IgG1 production and cooperates with IL-4 for the production of multiple Ab classes in vivo. IL-21R has been shown to activate the Janus kinase/signal transducers and activators of transcription signaling pathways upon ligand binding. Initial studies have demonstrated that IL-21 has pleiotropic effects on the proliferation, the differentiation, and the effector functions of B, T, natural killer, and dendritic cells. Recombinant mouse IL-21, produced in E.coli, is a single, non-glycosylated polypeptide chain containing 130 amino acids and having a total molecular mass of 15,095 Daltons.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 2 years from date of receipt.

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Bioinformatics

Gene Symbol IL21
Entrez