IL-17RB Antibody [Biotin]

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB, ELISA(Det)
Clonality
Polyclonal
Host
Goat
Conjugate
Biotin
Concentration
LYOPH

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Catalog# & Conjugate Size Price
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IL-17RB Antibody [Biotin] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse IL‑17 RB
Arg18-Gly286
Accession # Q9JIP3
Specificity
Detects mouse IL‑17 RB in ELISAs and Western blots. In sandwich immunoassays, less than 0.5% cross-reactivity with recombinant human IL‑17 RB, recombinant mouse (rm) IL-17 and rmIL-17 R is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
IL17RB
Purity
Antigen Affinity-purified
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.1 ug/mL
  • ELISA Capture (Matched Antibody Pair) 2-8 ug/mL
  • ELISA Detection (Matched Antibody Pair) 0.1-0.4 ug/mL
  • ELISA Standard (Matched Pair)
Application Notes
ELISA Capture: Mouse IL-17 RB Antibody (Catalog # MAB10401)
ELISA Detection: Mouse IL-17 RB Biotinylated Antibody (Catalog # BAF1040)
Standard: Recombinant Mouse IL-17 RB Fc Chimera (Catalog # 1040-BR)
Readout System
Publications
Read Publications using
BAF1040 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Preservative
No Preservative
Concentration
LYOPH
Purity
Antigen Affinity-purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IL-17RB Antibody [Biotin]

  • CRL4IL-17 receptor homolog 1
  • cytokine receptor CRL4
  • Cytokine receptor-like 4
  • Evi27
  • EVI27IL-17B receptor
  • IL-17 RB
  • IL-17 receptor B
  • IL-17 RH1
  • IL17BRinterleukin 17B receptor
  • IL-17ER
  • IL17RB
  • IL-17RB
  • IL17Rh1
  • IL-17Rh1
  • IL17RH1MGC5245
  • interleukin 17 receptor B
  • interleukin 17 receptor homolog 1
  • interleukin-17 receptor B
  • Interleukin-17B receptor

Background

The interleukin 17 (IL-17) family of cytokines, comprising six members (IL-17, IL-17B through IL-17F), are structurally related proteins with a conserved cysteine-knot structure. These proinflammatory cytokines can induce local cytokine production and are involved in the regulation of the immune response. The cognate receptors activated by some of these cytokines have been identified (1, 2). Interleukin-17B Receptor (IL-17RB), also known as IL-17 Rh1, IL-17E R and EVI27, represents the second receptor of the IL-17 family cytokines to be recognized (2‑4). Mouse IL17B R cDNA encodes a 499 amino acid (aa) residue type I membrane protein with a putative 17 aa signal peptide, a 269 aa extracellular domain, a 21 aa transmembrane domain and a 192 aa cytoplasmic tail. As a result of alternative splicing, a secreted variant of IL-17B R also exists (4). Human and mouse IL‑17B R share 76% aa sequence identity. The IL-17B R protein sequence is only 19.2% and 18.2% identical to the human and mouse IL-17 R sequence, respectively. However, the receptors share many conserved cysteine residues within their extracellular domains as well as additional conserved elements within their cytoplasmic domains. At least three additional type I transmembrane receptors with homology to IL‑17 R, including IL-17 RL (IL-17 RC), IL-17 RD, and IL-17 RE, have been reported (2, 6). By Northern blot analysis, mouse IL-17B R is highly expressed in liver and testes and is expressed at lower levels in kidney and lung. It is also expressed in some hematopoietic cell lines, including selected T cell, B cell, and myeloid cell lines (2‑4). The expression of IL-17B R is significantly up‑regulated under inflammatory conditions (7). IL-17 RB binds strongly to IL-17E and weakly to IL-17B. It does not bind IL-17 or IL-17F. Activation of IL-17B R by its ligands results in the activation of nuclear factor kappa-B (2‑4).

  1. Aggarwal, S. and A.L. Gurney (2002) J. Leukoc. Biol. 71:1.
  2. Moseley, T.A. et al. (2003) Cytokine & Growth Factor Rev. 14:155.
  3. Shi, Y. et al. (2000) J. Biol. Chem. 275:19167.
  4. Lee, J. et al. (2001) J. Biol. Chem. 276:1660.
  5. Tian, E. et al. (2000) Oncogene 19:2098.
  6. Haudenschild, D. et al. (2002) J. Biol. Chem. 277:4309.
  7. Hurst, S.D. et al. (2002) J. Immunol. 169:443.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for IL-17RB Antibody (BAF1040)(4)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 3 applications: Flow Cytometry, IHC, IHC-Fr.


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(2)
IHC
(1)
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Secondary Antibodies

 

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Other Available Formats

Biotin BAF1040

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Bioinformatics

Gene Symbol IL17RB
Uniprot