Biological Strategies: Western Blot: CDT2 Antibody [NB100-40840] - Detection of Human DTL/CDT2 by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa and 293T cells prepared using NETN lysis buffer. ...read more
Immunohistochemistry: CDT2 Antibody [NB100-40840] - Sample: FFPE section of mouse renal cell carcinoma. Antibody: Affinity purified rabbit anti-DTL/CDT2 used at a dilution of 1:200 (1ug/ml). Detection: DAB
Independent Antibodies: Western Blot: CDT2 Antibody [NB100-40840] - Detection of Human DTL/CDT2 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 ug for WB; 1 mg for IP, ...read more
Immunohistochemistry: CDT2 Antibody [NB100-40840] - Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-DTL/CDT2 used at a dilution of 1:200 (1ug/ml). Detection: DAB
The immunogen recognized by this antibody maps to a region between residue 680 and the C-terminus (residue 730) of human Denticleless Homolog (Chromatin Licensing and DNA Replicating Factor 2) using the numbering given in entry NP_057532.1 (GeneID 51514)
Immunogen affinity purified
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CDT2RA-regulated nuclear matrix-associated protein
DCAF2DDB1 and CUL4 associated factor 2
DDB1- and CUL4-associated factor 2
denticleless homolog (Drosophila)
L2DTLRA regulated nuclear matrix associated protein
Lethal(2) denticleless protein homolog
RAMPdenticleless protein homolog
Retinoic acid-regulated nuclear matrix-associated protein
DTL promotes genomic stability through two distinct mechanisms. First, it is an essential component of the CUL4-DDB1 complex that controls CDT1 levels, thereby preventing rereplication. Second, it is required for the early G2/M checkpoint.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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