IL-17RA/IL-17R Antibody (49M4D2) [DyLight 550]

• Reactivity: Hu
• Applications: WB, IHC
• Clone: 49M4D2
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 550

IL-17RA/IL-17R Antibody (49M4D2) [DyLight 550] Summary

• Description: This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
• Immunogen: Within the range of amino acids 186-267 of human IL-17RA were used as the immunogen for the antibody.
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: IL17RA
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for IL-17RA/IL-17R Antibody (49M4D2) [DyLight 550]

• CD217 antigen
• CD217
• Cdw217
• CDw217interleukin 17 receptor
• hIL-17R
• IL-17 R
• IL-17 RA
• IL-17 receptor A
• IL17RA
• IL-17RA
• IL-17RAMGC10262
• IL17Rinterleukin-17 receptor A
• interleukin 17 receptor A

Background

IL17RA is a gene that codes for a widely expressed protein that functions as a receptor for IL17A (a proinflammatory cytokine secreted by T-lymphocytes) with low affinity, which suggests that additional components are necessary to induce signaling and has a length of 866 amino acids and a weight of approximately 96 kDa. Current studies are being done on several diseases and disorders related to this gene including rheumatoid arthritis, cat eye syndrome, candidiasis, pituitary adenoma, bronchiolitis, cystic fibrosis, Sjogren's syndrome, keratitis, myocarditis, hepatitis B, liver disease, gingivitis, and osteoarthritis. IL17RA has also been shown to have interactions with IL17F, IL17RE, UBC, and TRAF3IP2 in pathways such as the IL-21 signaling, NF-kappaB signaling, and cytokine production pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

FAQs for IL-17RA/IL-17R Antibody (NBP2-25271R). (Showing 1 - 1 of 1 FAQ).

1. I am now using your product NBP2-25271R. What is the excitation wavelength and the corresponding emission wavelength for dylight 550? When I used the emission wavelength of 576nm and 670 nm ,no detection of il17 present. 
   •  The datasheet says that NBP2-25271R (IL-17 RA/IL-17 R Antibody (49M4D2) [DyLight 550]) has been only validated in WB and IHC-P with the human samples. For using this antibody besides the noted applications and species, the users will be automatically qualified for our Innovators' Reward Program; i.e. the next primary antibody free from us. Furthermore, the datasheet indicates that the excitation and emission wavelengths for DyLight 550 are 562 nm and 576 nm, respectively. Therefore for detecting signals that are produced by the dye, the input laser light should be set around 560 nm and the channel for detection of the emitted light of DL550 should be set at ~575nm (yellow color).

Bioinformatics

• Gene Symbol: IL17RA