Recombinant Human, Mouse IL-15 Fc, Mutant Protein [Biotin]

• Reactivity: Hu, Mu
• Applications: PAGE
• Conjugate: Biotin
• Concentration: LYOPH

Recombinant Human, Mouse IL-15 Fc, Mutant Protein [Biotin] Summary

• Description: Extracellular domain of human IL-15 (aa 49-162) including mutations at Q149D and Q156D fused to the N-terminus of the Fc region of mouse IgG2a.
  
  Source: CHO cells

  NCBI: NP_751914

• Source: CHO
• Protein/Peptide Type: Recombinant Protein
• Gene: IL15
• Purity: >98%, by SDS-PAGE
• Endotoxin Note: <0.06EU/ug protein (LAL test; Lonza).

Applications/Dilutions

• Dilutions:
  • SDS-Page

Reactivity Notes

The extracellular domain of human IL-15 (aa 49-162) including mutations at Q149D and Q156D is fused to the N-terminus of the Fc region of mouse IgG2a.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Lyophilized from PBS
• Preservative: 0.09% Sodium Azide
• Concentration: LYOPH
• Purity: >98%, by SDS-PAGE

Alternate Names for Recombinant Human, Mouse IL-15 Fc, Mutant Protein [Biotin]

• IL15
• IL-15
• IL-15MGC9721
• interleukin 15
• interleukin-15

Background

IL-15 (14-15 kD) is a member of the four alpha-helical bundle family of cytokines. It is very similar to IL-2, except that IL-15 has an IL-15 alpha receptor subunit. IL-15 plays an important role in the growth and differentiation of T and B lymphocytes, natural killer cells, macrophages, and monocytes as well as activation of a number of important intracellular signaling molecules. This implies that IL-15 could be essential for the immune responses, allograft rejection, and the pathogenesis of autoimmune diseases.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: IL15