IL-1 RI Antibody (40101)

Images

 
Immunohistochemistry-Paraffin: IL-1 RI Antibody (40101) [NBP1-50304] - Analysis of anti-IL1R1 antibody with human placenta at concentration 10 ug/ml.
Immunohistochemistry-Paraffin: IL-1 RI Antibody (40101) [NBP1-50304] - Analysis of anti-IL1R1 antibody with sheep tonsil. Image from verified customer review.

Product Details

Summary
Reactivity Hu, ShSpecies Glossary
Applications ELISA, IHC-P, RIA, WB (-)
Clone
40101
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
0.77 mg/ml

Order Details

IL-1 RI Antibody (40101) Summary

Immunogen
The extracellular domain of the type I human IL-1 receptor.
Specificity
These antibodies react with cell surface and soluble human IL-1 receptor; Specific epitopes are unknown, but they do partially inhibit (30-50%) binding of one another to IL-1 receptor. They do not block binding of IL-1 to receptor, and they do not cross-react with receptors for human IL-2 or IL-4.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
IL1R1
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA 1:100 - 1:2000
  • Immunohistochemistry-Paraffin 10 ug/ml
  • Radioimmunoassay 1:100 - 1:2000
Reviewed Applications
Read 1 Review rated 4
using
NBP1-50304 in the following applications:

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4) Sourced in Ascites.
Preservative
No Preservative
Concentration
0.77 mg/ml
Purity
Protein G purified

Alternate Names for IL-1 RI Antibody (40101)

  • CD121 antigen-like family member A
  • CD121a antigen
  • CD121a
  • IL-1 RI
  • IL1R
  • IL1R1
  • IL1RI
  • IL-1RI
  • IL1RT1
  • IL-1RT1
  • IL-1RT-1
  • Interleukin 1 Receptor 1
  • interleukin 1 receptor, type I
  • interleukin receptor 1
  • interleukin-1 receptor type 1
  • p80

Background

The Interleukin 1 receptor type I (IL-1R1) belongs to the IL-1 receptor family (1). IL-1R1 binds to IL-1 alpha, IL-1 beta, and interleukin-1 receptor antagonist protein (IL-1RA). IL-1RA regulates IL-1 ligand biological activity by a competitive interaction for IL-1R1. Upon IL-1 stimulation, adaptor molecule MyD88 is first recruited to the IL-1R1-IL1R accessory protein complex, followed by the recruitment of two serine-threonine kinases, IRAK4 and IRAK, and the adaptor protein TRAF6, resulting in activation of the NF-kB pathway (2-3). Stimulation of IL-1R1, leads to activation of the transcription factors NF-B, ATF, and AP-1 (4-5).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for IL-1 RI Antibody (NBP1-50304) (0)

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Review for IL-1 RI Antibody (NBP1-50304) (1) 41

Average Rating: 4
(Based on 1 review)
We have 1 review tested in 1 species: Other.
We have 1 review tested in 1 application: IHC-P.

Reviews using NBP1-50304:
Filter by Applications
IHC-P
(1)
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Filter by Species
Other
(1)
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Images Ratings Applications Species Date Details
Immunohistochemistry-Paraffin IL-1 RI NBP1-50304
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reviewed by:
Anonymous
IHC-P Other 08/18/2014
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Summary

ApplicationImmunohistochemistry-Paraffin
Sample Testedsheep tonsil
SpeciesOther

Primary Anitbody

Dilution Ratio1:150

Details

Fixation DetailsFFPE antigen retrieval pH6 overnight at 60C

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FAQs for IL-1 RI Antibody (NBP1-50304) (0)

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Secondary Antibodies

 

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Recent Reviews

4
5
0
4
1
3
0
2
0
1
0

Anonymous
08/18/2014
Application: IHC-P
Species: Other

Bioinformatics

Gene Symbol IL1R1
Entrez
Uniprot