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The Interleukin 1 receptor type I (IL-1R1) belongs to the IL-1 receptor family (1). IL-1R1 binds to IL-1 alpha, IL-1 beta, and interleukin-1 receptor antagonist protein (IL-1RA). IL-1RA regulates IL-1 ligand biological activity by a competitive interaction for IL-1R1. Upon IL-1 stimulation, adaptor molecule MyD88 is first recruited to the IL-1R1-IL1R accessory protein complex, followed by the recruitment of two serine-threonine kinases, IRAK4 and IRAK, and the adaptor protein TRAF6, resulting in activation of the NF-kB pathway (2-3). Stimulation of IL-1R1, leads to activation of the transcription factors NF-B, ATF, and AP-1.
![Immunohistochemistry IL-1 RI Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/IL1_RI_AF771_Immunohistochemistry_22597.jpg)
![Flow Cytometry IL-1 RI Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/IL-1_RI_AF269_Flow_Cytometry_9910.jpg)
![Sandwich ELISA IL-1 RI Antibody Pair [HRP]](http://images.novusbio.com/fullsize/IL-1-RI-Antibody-Pair-[HRP]-Sandwich-ELISA-NBP2-79604-img0001.jpg)
![Sandwich ELISA IL-1 RI Antibody Pair [HRP]](http://images.novusbio.com/fullsize/IL-1-RI-Antibody-Pair-[HRP]-Sandwich-ELISA-NBP2-79665-img0001.jpg)
![Sandwich ELISA IL-1 RI Antibody Pair [HRP]](http://images.novusbio.com/fullsize/IL-1-RI-Antibody-Pair-[HRP]-Sandwich-ELISA-NBP2-79625-img0001.jpg)
![N/A IL-1 RI [Biotin]](http://images.novusbio.com/fullsize2/DATA_IL1_RI_DY269_ELISA_1875.jpg)
![N/A IL-1 RI [Biotin]](http://images.novusbio.com/fullsize2/DATA_IL1_RI_DY77105_ELISA_2513.jpg)
![Binding Activity IL-1 RI [Biotin]](http://images.novusbio.com/fullsize/avi11085_recombinant-human-il-1-ri-fc-chimera-avi-tag-protein-cf-binding-activity-111020248335.jpg)
![Neutralization IL-1 RI Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/IL-1_RI_AF771_Block_Neutralize_8962.jpg)
![Neutralization IL-1 RI Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/IL-1_RI_AF269_Block_Neutralize_8838.jpg)
![Immunocytochemistry/ Immunofluorescence IL-1 RI Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af269_human-il-1-ri-affinity-purified-polyclonal-ab-8220249505956.jpg)
![Immunocytochemistry/ Immunofluorescence IL-1 RI Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af269_human-il-1-ri-affinity-purified-polyclonal-ab-44202415425024.jpg)
![SDS-PAGE IL-1 RI [Biotin]](http://images.novusbio.com/fullsize/avi11085_recombinant-human-il-1-ri-fc-chimera-avi-tag-protein-cf-sds-page-1110202484536..jpg)