IL-1 beta/IL-1F2 Antibody [Unconjugated]

Western blot shows lysates of THP‑1 human acute monocytic leukemia cell line untreated (-)ortreated (+) with 200 nM PMA for 24 hoursand 10 μg/mL LPS for 4 hours andRAW 264.7 mouse monocyte/macrophagecell line untreated (-)or treated (+) with10 μg/mL LPS for 24 hours. PVDF membrane was probed with 0.25 µg/mL of Goat Anti-Mouse IL‑1 beta /IL‑1F2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-401-NA) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF017). A specific band was detected for IL‑1 beta /IL‑1F2 at approximately 35 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

IL‑1 beta /IL‑1F2 was detected in immersion fixed MCF‑7 human breast cancer cell line using Goat Anti-Mouse IL‑1 beta /IL‑1F2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-401-NA) at 8 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL001) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

IL‑1 beta /IL‑1F2 was detected in perfusion fixed frozen sections of mouse thymus using Goat Anti-Mouse IL‑1 beta /IL‑1F2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-401-NA) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.

Simple Western lane view shows lysates of RAW 264.7 mouse monocyte/macrophage cell line untreated (-) or treated (+) with 10 µg/mL LPS for 24 hours, loaded at 0.5 mg/mL. A specific band was detected for IL‑1 beta /IL‑1F2 at approximately 40 kDa (as indicated) using 2.5 µg/mL of Goat Anti-Mouse IL‑1 beta /IL‑1F2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-401-NA) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.

Recombinant MouseIL‑1 beta /IL‑1F2 (Catalog # 401-ML) stimulates proliferation in the the D10.G4.1 mouse helper T cell line in a dose-dependent manner (orange line) as measured by Resazurin (Catalog # AR002). Proliferation elicited by Recombinant Mouse IL‑1 beta /IL‑1F2 (50 pg/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Mouse IL-1 beta /IL-1F2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-401-NA). The ND50 is typically ≤0.25 µg/mL.

IL‑1 beta /IL‑1F2 was detected in perfusion fixed paraffin-embedded sections of Mouse Intestine using Goat Anti-Mouse IL‑1 beta /IL‑1F2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-401-NA) at 5 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Sheep IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC006). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using VisUCyte Antigen Retrieval Reagent-Basic (Catalog # VCTS021). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm in epithelial cells. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

• Reactivity: Mu
• Applications: WB, Simple Western, IHC, B/N, ICC/IF
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: LYOPH

IL-1 beta/IL-1F2 Antibody [Unconjugated] Summary

• Immunogen: E. coli-derived recombinant mouse IL-1 beta /IL-1F2
  Val118-Ser269
  Accession # NP_032387
• Specificity: Detects mouse IL-1 beta /IL-1F2 in direct ELISAs and Western blots.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: IL1B
• Purity Statement: Antigen Affinity-purified
• Endotoxin Note: <0.10 EU per 1 μg of the antibody by the LAL method.

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry 5-15 ug/mL
  • Immunohistochemistry 5-15 ug/mL
  • Neutralization ≤0.25 ug/mL
  • Simple Western 2.5 ug/mL
  • Western Blot 0.25 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IL-1 beta/IL-1F2 Antibody [Unconjugated]

• catabolin
• IL1 beta
• IL-1 beta
• IL-1
• IL1B
• IL-1b
• IL1-BETA
• IL-1F2
• IL1F2IL-1 beta
• interleukin 1, beta
• interleukin-1 beta
• preinterleukin 1 beta
• pro-interleukin-1-beta

Background

IL-1 is a name that designates two pleiotropic cytokines, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2, IL1B), which are the products of distinct genes. IL-1 alpha and IL-1 beta are structurally related polypeptides that share approximately 17% amino acid (aa) identity in mouse. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL-1 alpha and IL-1 beta are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1 RI binds directly to IL-1 alpha or IL-1 beta and then associates with IL-1 R accessory protein (IL-1 R3/IL-1 R AcP) to form a high-affinity receptor complex that is competent for signal transduction. IL-1 RII has high affinity for IL-1 beta but functions as a decoy receptor and negative regulator of IL-1 beta activity. IL-1ra functions as a competitive antagonist by preventing IL-1 alpha and IL-1 beta from interacting with IL-1 RI. Intracellular cleavage of the IL-1 beta precursor by Caspase-1/ICE is a key step in the inflammatory response. The 17 kDa molecular weight mature mouse IL-1 beta shares 90% aa sequence identity with cotton rat and rat and 67%-78% with canine, equine, feline, human, porcine, and rhesus macaque IL-1 beta . IL-1 beta functions in a central role in immune and inflammatory responses, bone remodeling, fever, carbohydrate metabolism, and GH/IGF-I physiology. IL-1 beta dysregulation is implicated in many pathological conditions including sepsis, rheumatoid arthritis, inflammatory bowel disease, acute and chronic myelogenous leukemia, insulin-dependent diabetes mellitus, atherosclerosis, neuronal injury, and aging-related diseases.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for IL-1 beta/IL-1F2 Antibody (AF-401-NA)(271)

Publications using AF-401-NA

• Sin, R;Sotogaku, N;Ohnishi, YN;Shuto, T;Kuroiwa, M;Kawahara, Y;Sugiyama, K;Murakami, Y;Kanai, M;Funakoshi, H;Chakraborti, A;Bibb, JA;Nishi, A; Inhibition of STAT-mediated cytokine responses to chemically-induced colitis prevents inflammation-associated neurobehavioral impairments Brain, behavior, and immunity 2023-08-23 [PMID: 37625556] (Western Blot, Mouse)
• Bai, Y;Min, R;Chen, P;Mei, S;Deng, F;Zheng, Z;Jiang, C;Miao, R;Wu, Z;Zhang, P;Pan, Y;Lieberman, J;Liu, X; Disulfiram blocks inflammatory TLR4 signaling by targeting MD-2 Proceedings of the National Academy of Sciences of the United States of America 2023-08-01 [PMID: 37487070] (Western Blot, Mouse)
• Zhang, Z;Song, J;Kwon, SH;Wang, Z;Park, SG;Piao, X;Ryu, JH;Kim, N;Kim, OS;Kim, SH;Koh, JT; Pirfenidone Inhibits Alveolar Bone Loss in Ligature-Induced Periodontitis by Suppressing the NF-?B Signaling Pathway in Mice International journal of molecular sciences 2023-05-12 [PMID: 37240020] (IHC, Mouse)
• Weerasinghe, H;Simm, C;Djajawi, TM;Tedja, I;Lo, TL;Simpson, DS;Shasha, D;Mizrahi, N;Olivier, FAB;Speir, M;Lawlor, KE;Ben-Ami, R;Traven, A; Candida auris uses metabolic strategies to escape and kill macrophages while avoiding robust activation of the NLRP3 inflammasome response Cell reports 2023-05-18 [PMID: 37204928] (Western Blot, Mouse)
• Ren, M;Chen, J;Xu, H;Li, W;Wang, T;Chi, Z;Lin, Y;Zhang, A;Chen, G;Wang, X;Sun, X;Liang, G;Wang, J;Luo, W; Ergolide covalently binds NLRP3 and inhibits NLRP3 inflammasome-mediated pyroptosis International immunopharmacology 2023-05-12 [PMID: 37182452] (Western Blot, Transgenic Mouse, Mouse)
• Liu, L;Feng, L;Gao, J;Hu, J;Li, A;Zhu, Y;Zhang, C;Qiu, B;Shen, Z; Parthenolide targets NLRP3 to treat inflammasome-related diseases International immunopharmacology 2023-06-01 [PMID: 37167640] (Bioassay, Mouse)
• Huang, LS;Anas, M;Xu, J;Zhou, B;Toth, PT;Krishnan, Y;Di, A;Malik, AB; Endosomal trafficking of two-pore K+ efflux channel TWIK2 to plasmalemma mediates NLRP3 inflammasome activation and inflammatory injury eLife 2023-05-09 [PMID: 37158595] (Mouse)
• Siopi, E;Galerne, M;Rivagorda, M;Saha, S;Moigneu, C;Moriceau, S;Bigot, M;Oury, F;Lledo, PM; Gut microbiota changes require vagus nerve integrity to promote depressive-like behaviors in mice Molecular psychiatry 2023-05-02 [PMID: 37131071] (Western Blot, Mouse)
• JH Kang, SB Lee, J Seok, DH Kim, G Ma, J Park, AJ Jeong, SK Ye, TB Kang Novel Activity of ODZ10117, a STAT3 Inhibitor, for Regulation of NLRP3 Inflammasome Activation International Journal of Molecular Sciences, 2023-03-23;24(7):. 2023-03-23 [PMID: 37047051] (Western Blot, Mouse)
• A Ta, R Ricci-Azev, SO Vasudevan, SS Wright, P Kumari, MS Havira, M Surendran, VA Rathinam, SK Vanaja A bacterial autotransporter impairs innate immune responses by targeting the transcription factor TFE3 Nature Communications, 2023-04-11;14(1):2035. 2023-04-11 [PMID: 37041208] (Western Blot, Mouse)
• S Bollenbeck, K Heitman, B Czaya, M Easter, MJ Hirsch, S Vang, E Harris, ES Helton, JW Barnes, C Faul, S Krick Phosphate induces inflammation and exacerbates injury from cigarette smoke in the bronchial epithelium Scientific Reports, 2023-03-25;13(1):4898. 2023-03-25 [PMID: 36966182] (IHC, Mouse)
• J Li, Q Lin, X Shao, S Li, X Zhu, J Wu, S Mou, L Gu, Q Wang, M Zhang, K Zhang, J Lu, Z Ni HIF1alpha-BNIP3-mediated mitophagy protects against renal fibrosis by decreasing ROS and inhibiting activation of the NLRP3 inflammasome Cell Death & Disease, 2023-03-17;14(3):200. 2023-03-17 [PMID: 36928344] (ICC, IHC, Western Blot, Mouse)
• TT Lin, CY Jiang, L Sheng, L Wan, W Fan, JC Li, XD Sun, CJ Xu, L Hu, XF Wu, Y Han, WT Liu, YB Pan Suppressing high mobility group box-1 release alleviates morphine tolerance via the adenosine 5&#039;-monophosphate-activated protein kinase/heme oxygenase-1 pathway Neural regeneration research, 2023-09-01;18(9):2067-2074. 2023-09-01 [PMID: 36926733] (Western Blot, Mouse)
• Y Chen, J Pu, X Li, L Lian, C Ge, Z Liu, W Wang, L Hou, W Chen, J Li Aim2 Deficiency Ameliorates Lacrimal Gland Destruction and Corneal Epithelium Defects in an Experimental Dry Eye Model Investigative Ophthalmology & Visual Science, 2023-03-01;64(3):26. 2023-03-01 [PMID: 36920364] (Western Blot, Mouse)
• A Hooftman, CG Peace, DG Ryan, EA Day, M Yang, AF McGettrick, M Yin, EN Montano, L Huo, JE Toller-Kaw, V Zecchini, TAJ Ryan, A Bolado-Car, AM Casey, HA Prag, ASH Costa, G De Los San, M Ishimori, DJ Wallace, S Venuturupa, E Nikitopoul, N Frizzell, C Johansson, A Von Kriegs, MP Murphy, C Jefferies, C Frezza, LAJ O'Neill Macrophage fumarate hydratase restrains mtRNA-mediated interferon production Nature, 2023-03-08;615(7952):490-498. 2023-03-08 [PMID: 36890227] (Western Blot, Mouse)
• WJ Zhong, J Zhang, JX Duan, CY Zhang, SC Ma, YS Li, NS Yang, HH Yang, JB Xiong, CX Guan, ZX Jiang, ZJ You, Y Zhou TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury Journal of Translational Medicine, 2023-03-06;21(1):179. 2023-03-06 [PMID: 36879273] (Western Blot, Mouse)
• A Filippini, V Salvi, V Dattilo, C Magri, S Castrezzat, R Veerhuis, D Bosisio, M Gennarelli, I Russo LRRK2 Kinase Inhibition Attenuates Astrocytic Activation in Response to Amyloid beta1-42 Fibrils Biomolecules, 2023-02-06;13(2):. 2023-02-06 [PMID: 36830676] (Western Blot, Mouse)
• Y Wang, D Sadike, B Huang, P Li, Q Wu, N Jiang, Y Fang, G Song, L Xu, W Wang, M Xie Regulatory T cells alleviate myelin loss and cognitive dysfunction by regulating neuroinflammation and microglial pyroptosis via TLR4/MyD88/NF-kappaB pathway in LPC-induced demyelination Journal of Neuroinflammation, 2023-02-18;20(1):41. 2023-02-18 [PMID: 36803990] (IHC, Mouse)
• X Shu, C Wei, WY Tu, K Zhong, S Qi, A Wang, L Bai, SX Zhang, B Luo, ZZ Xu, K Zhang, C Shen Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome Cell Reports, 2023-02-16;42(2):112133. 2023-02-16 [PMID: 36800288] (Western Blot, Mouse)
• A Ramadan, Z Cao, M Gadjeva, TS Zaidi, VA Rathinam, N Panjwani The NLRP3 Inflammasome Is Required for Protection Against Pseudomonas Keratitis Investigative Ophthalmology & Visual Science, 2023-02-01;64(2):11. 2023-02-01 [PMID: 36749596] (Western Blot, Mouse)
• G Lin, N Li, D Li, L Chen, H Deng, S Wang, J Tang, W Ouyang Carnosic acid inhibits NLRP3 inflammasome activation by targeting both priming and assembly steps International immunopharmacology, 2023-02-02;116(0):109819. 2023-02-02 [PMID: 36738671] (Western Blot, Mouse)
• MB Reynolds, HS Hong, BC Michmerhui, AE Lawrence, L Zhang, JS Knight, CA Lyssiotis, BH Abuaita, MX O'Riordan Cardiolipin coordinates inflammatory metabolic reprogramming through regulation of Complex II disassembly and degradation Science Advances, 2023-02-03;9(5):eade8701. 2023-02-03 [PMID: 36735777] (Western Blot, Mouse)
• L González-C, J P Green, I Cuadrado, Á Amesty, S Oramas-Roy, David Brou, A Estévez-Br, S Hortelano, B de Las Her Phenolic and quinone methide nor-triterpenes as selective NLRP3 inflammasome inhibitors Bioorganic chemistry, 2023-01-14;132(0):106362. 2023-01-14 [PMID: 36657273] (Western Blot, Mouse)
• HW Xu, WF Li, SS Hong, JJ Shao, JH Chen, N Chattipako, D Wu, W Luo, G Liang Tabersonine, a natural NLRP3 inhibitor, suppresses inflammasome activation in macrophages and attenuate NLRP3-driven diseases in mice Acta pharmacologica Sinica, 2023-01-10;0(0):. 2023-01-10 [PMID: 36627344] (Western Blot, Mouse)
• G Lee, H Ahn, JH Yun, J Park, E Lee, S Oh, GS Lee JC2-11, a benzylideneacetophenone derivative, attenuates inflammasome activation Scientific Reports, 2022-12-28;12(1):22484. 2022-12-28 [PMID: 36577816] (Western Blot, Mouse)
• SK Juin, S Pushpakuma, SC Tyagi, U Sen Glucosidase inhibitor, Nimbidiol ameliorates renal fibrosis and dysfunction in type-1 diabetes Scientific Reports, 2022-12-15;12(1):21707. 2022-12-15 [PMID: 36522378] (Western Blot, Mouse)
• LM Branco, MP Amaral, H Boekhoff, ABF de Lima, IS Farias, SL Lage, GJS Pereira, BS Franklin, KR Bortoluci Lysosomal cathepsins act in concert with Gasdermin-D during NAIP/NLRC4-dependent IL-1beta secretion Cell Death & Disease, 2022-12-08;13(12):1029. 2022-12-08 [PMID: 36481780] (Mouse)
• C Oh, L Li, A Verma, AD Reuven, EA Miao, JB Bliska, Y Aachoui Neutrophil inflammasomes sense the subcellular delivery route of translocated bacterial effectors and toxins Cell Reports, 2022-11-22;41(8):111688. 2022-11-22 [PMID: 36417874] (Western Blot, Mouse, Transgenic Mouse)
• YH Wu, ST Mo, IT Chen, FY Hsieh, SL Hsieh, J Zhang, MZ Lai Caspase-8 inactivation drives autophagy-dependent inflammasome activation in myeloid cells Science Advances, 2022-11-11;8(45):eabn9912. 2022-11-11 [PMID: 36367942] (Western Blot, Transgenic Mouse)
• MSJ Mangan, F Gorki, K Krause, A Heinz, A Pankow, T Ebert, D Jahn, K Hiller, V Hornung, M Maurer, FI Schmidt, R Gerhard, E Latz Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever PloS Biology, 2022-11-07;20(11):e3001351. 2022-11-07 [PMID: 36342970] (Western Blot, Human)
• SL Kim, MW Shin, SW Kim Lipocalin 2 activates the NLRP3 inflammasome via LPS?induced NF?kappaB signaling and plays a role as a pro?inflammatory regulator in murine macrophages Molecular Medicine Reports, 2022-10-20;26(6):. 2022-10-20 [PMID: 36263611] (Western Blot, Mouse)
• Q Lin, D Zhang, J Zhang, W Luo, Z Xu, J Yao, L Wang Identification of lncRNA DLEU2 as a potential diagnostic biomarker and anti-inflammatory target for ulcerative colitis Frontiers in Pharmacology, 2022-09-14;13(0):991448. 2022-09-14 [PMID: 36188540] (Western Blot, Human)
• P Sharma, K Karnam, A Mahale, K Sedmaki, V Krishna Ve, OP Kulkarni HDAC5 RNA interference ameliorates acute renal injury by upregulating KLF2 and inhibiting NALP3 expression in a mouse model of oxalate nephropathy International immunopharmacology, 2022-09-29;112(0):109264. 2022-09-29 [PMID: 36183679] (Western Blot, Mouse)
• AA Abdelrahma, KL Bunch, PV Sandow, PN Cheng, RB Caldwell, RW Caldwell Systemic Administration of Pegylated Arginase-1 Attenuates the Progression of Diabetic Retinopathy Cells, 2022-09-16;11(18):. 2022-09-16 [PMID: 36139465] (Western Blot, Mouse)
• M Duhalde Ve, D Olivera, G Gastão Dav, M Bertullo, V Noya, G Fabiano de, S Primon Mur, I Castro, AP Arévalo, M Crispo, G Galliussi, S Russo, D Charbonnie, F Rammauro, M Jeldres, C Alamón, V Varela, C Batthyany, M Bollati-Fo, P Oppezzo, O Pritsch, JL Proença-Mó, HI Nakaya, E Trias, L Barbeito, I Anegon, MC Cuturi, P Moraes-Vie, M Segovia, M Hill PD-1/PD-L1 blockade abrogates a dysfunctional innate-adaptive immune axis in critical beta-coronavirus disease Science Advances, 2022-09-21;8(38):eabn6545. 2022-09-21 [PMID: 36129987] (Neutralization, Mouse)
• I de Castro, A Bianchi, NU Deshpande, P Sharma, S Mehra, VT Garrido, SJ Saigh, J England, PJ Hosein, D Kwon, NB Merchant, J Datta Neutrophil-mediated fibroblast-tumor cell il-6/stat-3 signaling underlies the association between neutrophil-to-lymphocyte ratio dynamics and chemotherapy response in localized pancreatic cancer: A hybrid clinical-preclinical study Elife, 2022-09-15;11(0):. 2022-09-15 [PMID: 36107485] (Neutralization, Mouse)
• Y Zhu, H Zhang, H Mao, S Zhong, Y Huang, S Chen, K Yan, Z Zhao, X Hao, Y Zhang, H Yao, X Huang, M Wang, W Zhang, J Li, G Meng, X Qin, Z Ye, J Shen, Y Song, Y Xu, Z Yang, L Wang, Y Zhang, L Wen FAAH served a key membrane-anchoring and stabilizing role for NLRP3 protein independently of the endocannabinoid system Cell Death and Differentiation, 2022-09-14;0(0):. 2022-09-14 [PMID: 36104448] (Western Blot, Mouse)
• SM Ruwanpura, L McLeod, LF Dousha, HJ Seow, AC West, AJ West, T Weng, M Alanazi, M MacDonald, PT King, PG Bardin, C Gabay, DM Klinman, S Bozinovski, R Vlahos, GP Anderson, S Rose-John, MI Saad, BJ Jenkins Cross-talk between IL-6 trans-signaling and AIM2 inflammasome/IL-1beta axes bridge innate immunity and epithelial apoptosis to promote emphysema Proceedings of the National Academy of Sciences of the United States of America, 2022-08-29;119(36):e2201494119. 2022-08-29 [PMID: 36037355] (Western Blot, Mouse)
• H Shi, Y Zhu, C Xing, S Li, Z Bao, L Lei, D Lin, Y Wang, H Chen, X Xu An injectable thermosensitive hydrogel for dual delivery of diclofenac and Avastin� to effectively suppress inflammatory corneal neovascularization International journal of pharmaceutics, 2022-08-05;0(0):122081. 2022-08-05 [PMID: 35934166] (IHC, Rabbit)
• AQ Dong, YP Yang, SM Jiang, XY Yao, D Qi, CJ Mao, XY Cheng, F Wang, LF Hu, CF Liu Pramipexole inhibits astrocytic NLRP3 inflammasome activation via Drd3-dependent autophagy in a mouse model of Parkinson&#039;s disease Acta pharmacologica Sinica, 2022-07-27;0(0):. 2022-07-27 [PMID: 35896696] (Western Blot, Mouse)
• AB Lopez-Rodr, C Decouty-Pe, V Farré-Alin, A Palomino-A, P Narros-Fer, J Egea Activation of NLRP3 Is Required for a Functional and Beneficial Microglia Response after Brain Trauma Pharmaceutics, 2022-07-26;14(8):. 2022-07-26 [PMID: 35893807] (Western Blot, Mouse)
• JH Ma, E Lee, SH Yoon, H Min, JH Oh, I Hwang, Y Sung, JH Ryu, J Bok, JW Yu Therapeutic effect of NLRP3 inhibition on hearing loss induced by systemic inflammation in a CAPS-associated mouse model EBioMedicine, 2022-07-20;82(0):104184. 2022-07-20 [PMID: 35870427] (Western Blot, Mouse)
• W Chen, S Chen, C Yan, Y Zhang, R Zhang, M Chen, S Zhong, W Fan, S Zhu, D Zhang, X Lu, J Zhang, Y Huang, L Zhu, X Li, D Lv, Y Fu, H Iv, Z Ling, L Ma, H Jiang, G Long, J Zhu, D Wu, B Wu, B Sun Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion Nature Immunology, 2022-07-06;23(7):1021-1030. 2022-07-06 [PMID: 35794369] (Western Blot, Mouse)
• W Yu, Z Wang, X Yu, Y Zhao, Z Xie, K Zhang, Z Chi, S Chen, T Xu, D Jiang, X Guo, M Li, J Zhang, H Fang, D Yang, Y Guo, X Yang, X Zhang, Y Wu, W Yang, D Wang Kir2.1-mediated membrane potential promotes nutrient acquisition and inflammation through regulation of nutrient transporters Nature Communications, 2022-06-21;13(1):3544. 2022-06-21 [PMID: 35729093] (Western Blot, Mouse)
• Y Jin, Y Liu, L Xu, J Xu, Y Xiong, Y Peng, K Ding, S Zheng, N Yang, Z Zhang, L Li, L Tan, H Song, J Fu Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis Cell Death & Disease, 2022-05-31;13(5):512. 2022-05-31 [PMID: 35641492] (Western Blot, Mouse)
• Q Zhang, W Liu, H Wang, H Zhou, K Bulek, X Chen, CJ Zhang, J Zhao, R Zhang, C Liu, Z Kang, RA Bermel, G Dubyak, DW Abbott, TS Xiao, LE Nagy, X Li TH17 cells promote CNS inflammation by sensing danger signals via Mincle Nature Communications, 2022-05-03;13(1):2406. 2022-05-03 [PMID: 35504893] (Western Blot, Mouse)
• L Zhou, S Yang, X Zou Farrerol Alleviates Myocardial Ischemia/Reperfusion Injury by Targeting Macrophages and NLRP3 Frontiers in Pharmacology, 2022-04-13;13(0):879232. 2022-04-13 [PMID: 35496295] (Western Blot, Mouse)
• LK Billingham, JS Stoolman, K Vasan, AE Rodriguez, TA Poor, M Szibor, HT Jacobs, CR Reczek, A Rashidi, P Zhang, J Miska, NS Chandel Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation Nature Immunology, 2022-04-28;0(0):. 2022-04-28 [PMID: 35484407] (Western Blot, Mouse)
• ES Jung, K Suh, J Han, H Kim, HS Kang, WS Choi, I Mook-Jung Amyloid-beta activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk-AMPK pathway Aging Cell, 2022-04-27;0(0):e13623. 2022-04-27 [PMID: 35474599] (Western Blot, Mouse)
• F Li, L Lin, Y He, G Sun, D Dong, B Wu BMAL1 regulates Propionibacterium acnes-induced skin inflammation via REV-ERBalpha in mice International journal of biological sciences, 2022-03-21;18(6):2597-2608. 2022-03-21 [PMID: 35414779] (Western Blot, Mouse)
• K Molnár, B Nógrádi, R Kristóf, Á Mészáros, K Pajer, L Siklós, A Nógrádi, I Wilhelm, IA Krizbai Motoneuronal inflammasome activation triggers excessive neuroinflammation and impedes regeneration after sciatic nerve injury Journal of Neuroinflammation, 2022-03-19;19(1):68. 2022-03-19 [PMID: 35305649] (Western Blot, Mouse)
• CMA Rego, AF Francisco, CN Boeno, MV Paloschi, JA Lopes, MDS Silva, HM Santana, SN Serrath, JE Rodrigues, CTL Lemos, RSS Dutra, JN da Cruz, CBR Dos Santos, S da S Setúb, MRM Fontes, AM Soares, WL Pires, JP Zuliani Inflammasome NLRP3 activation induced by Convulxin, a C-type lectin-like isolated from Crotalus durissus terrificus snake venom Scientific Reports, 2022-03-18;12(1):4706. 2022-03-18 [PMID: 35304541] (ELISA, Human)
• B Czaya, K Heitman, I Campos, C Yanucil, D Kentrup, D Westbrook, O Gutierrez, JL Babitt, G Jung, IB Salusky, M Hanudel, C Faul Hyperphosphatemia increases inflammation to exacerbate anemia and skeletal muscle wasting independently of FGF23-FGFR4 signaling Elife, 2022-03-18;11(0):. 2022-03-18 [PMID: 35302487] (Neutralization, Mouse)
• MF Mohamed, K Gupta, JW Goldufsky, R Roy, LT Callaghan, DM Wetzel, TM Kuzel, J Reiser, SH Shafikhani CrkII/Abl phosphorylation cascade is critical for NLRC4 inflammasome activity and is blocked by Pseudomonas aeruginosa ExoT Nature Communications, 2022-03-11;13(1):1295. 2022-03-11 [PMID: 35277504] (Western Blot, Mouse)
• K Eislmayr, A Bestehorn, L Morelli, M Borroni, LV Walle, M Lamkanfi, P Kovarik Nonredundancy of IL-1alpha and IL-1beta is defined by distinct regulation of tissues orchestrating resistance versus tolerance to infection Science Advances, 2022-03-02;8(9):eabj7293. 2022-03-02 [PMID: 35235356] (Western Blot, Mouse)
• YT Wang, TY Liu, CH Shen, SY Lin, CC Hung, LC Hsu, GC Chen K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy Cell Reports, 2022-02-22;38(8):110354. 2022-02-22 [PMID: 35196483] (Western Blot, Mouse)
• Y Jiao, J Nan, B Mu, Y Zhang, N Zhou, S Yang, S Zhang, W Lin, F Wang, A Xia, Z Cao, P Chen, Z Pan, G Lin, S Pan, H Bin, L Li, S Yang Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis European Journal of Medicinal Chemistry, 2022-02-11;232(0):114194. 2022-02-11 [PMID: 35183871] (Western Blot, Mouse)
• T Xu, W Yu, H Fang, Z Wang, Z Chi, X Guo, D Jiang, K Zhang, S Chen, M Li, Y Guo, J Zhang, D Yang, Q Yu, D Wang, X Zhang Ubiquitination of NLRP3 by gp78/Insig-1 restrains NLRP3 inflammasome activation Cell Death and Differentiation, 2022-02-02;0(0):. 2022-02-02 [PMID: 35110683] (Western Blot, Human)
• K Tóth, N Lénárt, P Berki, R Fekete, E Szabadits, B Pósfai, C Cserép, A Alatshan, S Benk?, D Kiss, CA Hübner, A Gulyás, K Kaila, Z Környei, Á Dénes The NKCC1 ion transporter modulates microglial phenotype and inflammatory response to brain injury in a cell-autonomous manner PloS Biology, 2022-01-27;20(1):e3001526. 2022-01-27 [PMID: 35085235] (IHC, Mouse)
• S Wang, K Jing, H Wu, X Li, C Yang, T Li, H Tang, T Zou, Y She, HF Liu Activation of Transcription Factor EB Alleviates Tubular Epithelial Cell Injury via Restoring Lysosomal Homeostasis in Diabetic Nephropathy Oxidative Medicine and Cellular Longevity, 2022-01-12;2022(0):2812493. 2022-01-12 [PMID: 35082964] (Western Blot, Mouse)
• S Murthy, S Baruah, JL Bowen, K Keck, BA Wagner, GR Buettner, DB Sykes, J Klesney-Ta TREM-1 is required for enhanced OpZ-induced superoxide generation following priming Journal of leukocyte biology, 2022-01-24;0(0):. 2022-01-24 [PMID: 35075692] (Western Blot, Mouse)
• D Szabó, P Tod, F Gölöncsér, V Román, B Lendvai, L Otrokocsi, B Sperlágh Maternal P2X7 receptor inhibition prevents autism-like phenotype in male mouse offspring through the NLRP3-IL-1beta pathway Brain, Behavior, and Immunity, 2022-01-20;0(0):. 2022-01-20 [PMID: 35065198] (In Vivo, Mouse)
• MA Munoz, EK Fletcher, OP Skinner, J Jurczyluk, E Kristianto, MP Hodson, S Sun, FH Ebetino, DR Croucher, PM Hansbro, JR Center, MJ Rogers Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages Elife, 2021-12-30;10(0):. 2021-12-30 [PMID: 34967731] (Western Blot, Mouse)
• NC Williams, DG Ryan, ASH Costa, EL Mills, MP Jedrychows, SM Cloonan, C Frezza, LA O'Neill Signalling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1alpha in lipopolysaccharide-activated macrophages The Journal of Biological Chemistry, 2021-12-17;0(0):101501. 2021-12-17 [PMID: 34929172] (Western Blot, Mouse)
• K Yuan, J Zheng, X Shen, Y Wu, Y Han, X Jin, X Huang Sensory nerves promote corneal inflammation resolution via CGRP mediated transformation of macrophages to the M2 phenotype through the PI3K/AKT signaling pathway International immunopharmacology, 2021-12-11;102(0):108426. 2021-12-11 [PMID: 34906854] (IHC, Western Blot, Mouse)
• Z Wei, X Zhan, K Ding, G Xu, W Shi, L Ren, Z Fang, T Liu, X Hou, J Zhao, H Li, J Li, Z Li, Q Li, L Lin, Y Yang, X Xiao, Z Bai, J Cao Dihydrotanshinone I Specifically Inhibits NLRP3 Inflammasome Activation and Protects Against Septic Shock In Vivo Frontiers in Pharmacology, 2021-10-14;12(0):750815. 2021-10-14 [PMID: 34721038] (Western Blot, Mouse)
• P Chen, Q Bai, Y Wu, Q Zeng, X Song, Y Guo, P Zhou, Y Wang, X Liao, Q Wang, Z Ren, Y Wang The Essential Oil of Artemisia argyi H.L�v. and Vaniot Attenuates NLRP3 Inflammasome Activation in THP-1 Cells Frontiers in Pharmacology, 2021-09-16;12(0):712907. 2021-09-16 [PMID: 34603026] (Western Blot, Mouse)
• H Ahn, H Lee, G Lee, J Park, HW Sung, E Lee, GS Lee Parabens disrupt non-canonical inflammasome activation International immunopharmacology, 2021-09-30;101(0):108196. 2021-09-30 [PMID: 34601332] (Western Blot, Mouse)
• B Wen, YY Dang, SH Wu, YM Huang, KY Ma, YM Xu, XL Zheng, XY Dai Antiatherosclerotic effect of dehydrocorydaline on ApoE-/- mice: inhibition of macrophage inflammation Acta pharmacologica Sinica, 2021-09-22;0(0):. 2021-09-22 [PMID: 34552216] (Western Blot, Mouse)
• S Jiang, NM Maphis, J Binder, D Chisholm, L Weston, W Duran, C Peterson, A Zimmerman, MA Mandell, SD Jett, E Bigio, C Geula, N Mellios, JP Weick, GA Rosenberg, E Latz, MT Heneka, K Bhaskar Proteopathic tau primes and activates interleukin-1beta via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway Cell Reports, 2021-09-21;36(12):109720. 2021-09-21 [PMID: 34551296] (Western Blot, Mouse)
• Y Tang, KT Kline, XS Zhong, Y Xiao, H Lian, J Peng, X Liu, DW Powell, G Tang, Q Li Chronic colitis upregulates microRNAs suppressing brain-derived neurotrophic factor in the adult heart PLoS ONE, 2021-09-20;16(9):e0257280. 2021-09-20 [PMID: 34543287] (Neutralization, Rat)
• D Reimers, M Vallejo-Mu, MJ Casarejos, A Jimenez-Es, R Gonzalo-Go, E Bazan Immunohistochemical Study of ASC Expression and Distribution in the Hippocampus of an Aged Murine Model of Alzheimer&#039;s Disease International Journal of Molecular Sciences, 2021-08-13;22(16):. 2021-08-13 [PMID: 34445402] (Western Blot, Mouse)
• X Li, X Zhang, J Xia, L Zhang, B Chen, G Lian, C Yun, J Yang, Y Yan, P Wang, X Wang, B Liu, H Liu, H Liang, Y Pang, X Wang, C Jiang Macrophage HIF-2alpha suppresses NLRP3 inflammasome activation and alleviates insulin resistance Cell Reports, 2021-08-24;36(8):109607. 2021-08-24 [PMID: 34433035] (ChIP, ICC, Western Blot, Mouse)
• P Ortiz-Rome, A González-S, G Egea, LA Pérez-Jura, V Campuzano Co-Treatment With Verapamil and Curcumin Attenuates the Behavioral Alterations Observed in Williams-Beuren Syndrome Mice by Regulation of MAPK Pathway and Microglia Overexpression Frontiers in Pharmacology, 2021-08-03;12(0):670785. 2021-08-03 [PMID: 34413771] (IHC, Mouse)
• H Ahn, G Lee, J Kim, J Park, SG Kang, SI Yoon, E Lee, GS Lee NLRP3 Triggers Attenuate Lipocalin-2 Expression Independent with Inflammasome Activation Cells, 2021-07-02;10(7):. 2021-07-02 [PMID: 34359830] (Western Blot, Mouse)
• XY Wu, JY Lv, SQ Zhang, X Yi, ZW Xu, YX Zhi, BX Zhao, JX Pang, KKL Yung, SW Liu, PZ Zhou ML365 inhibits TWIK2 channel to block ATP-induced NLRP3 inflammasome Acta pharmacologica Sinica, 2021-08-02;0(0):. 2021-08-02 [PMID: 34341510] (Western Blot, Mouse)
• S Rastogi, S Ellinwood, J Augenstrei, KD Mayer-Barb, V Briken Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF PloS Pathogens, 2021-07-29;17(7):e1009712. 2021-07-29 [PMID: 34324582] (Western Blot, Mouse)
• S Nizami, V Millar, K Arunasalam, T Zarganes-T, D Brough, G Tresadern, PE Brennan, JB Davis, D Ebner, E Di Daniel A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation Scientific Reports, 2021-07-28;11(1):15319. 2021-07-28 [PMID: 34321581] (Western Blot, Mouse)
• CC Lin, YR Shen, CC Chang, XY Guo, YY Young, TY Lai, IS Yu, CY Lee, TH Chuang, HY Tsai, LC Hsu Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation Nature Communications, 2021-06-29;12(1):3878. 2021-06-29 [PMID: 34188032] (Western Blot, Mouse)
• B Ratitong, M Marshall, E Pearlman &amp;beta-Glucan-stimulated neutrophil secretion of IL-1&amp;alpha is independent of GSDMD and mediated through extracellular vesicles Cell Reports, 2021-05-18;35(7):109139. 2021-05-18 [PMID: 34010648] (Neutralization, Human)
• SL Vijayaraj, R Feltham, M Rashidi, D Frank, Z Liu, DS Simpson, G Ebert, A Vince, MJ Herold, A Kueh, JS Pearson, LF Dagley, JM Murphy, AI Webb, KE Lawlor, JE Vince The ubiquitylation of IL-1&amp;beta limits its cleavage by caspase-1 and targets it for proteasomal degradation Nature Communications, 2021-05-11;12(1):2713. 2021-05-11 [PMID: 33976225] (Western Blot, Mouse)
• S Xia, Z Zhang, VG Magupalli, JL Pablo, Y Dong, SM Vora, L Wang, TM Fu, MP Jacobson, A Greka, J Lieberman, J Ruan, H Wu Gasdermin D pore structure reveals preferential release of mature interleukin-1 Nature, 2021-04-21;0(0):. 2021-04-21 [PMID: 33883744] (Western Blot, Mouse)
• X Wang, Z Li, Y Bai, R Zhang, R Meng, F Chen, H Wang, TR Billiar, X Xiao, B Lu, Y Tang A small molecule binding HMGB1 inhibits caspase-11-mediated lethality in sepsis Cell Death & Disease, 2021-04-14;12(4):402. 2021-04-14 [PMID: 33854044] (Flow Cytometry, Proximity Ligation Assay, Western Blot, Mouse)
• B Zhou, DW Abbott Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases Cell Reports, 2021-04-13;35(2):108998. 2021-04-13 [PMID: 33852854] (Western Blot, Mouse)
• C Zhang, H Yue, P Sun, L Hua, S Liang, Y Ou, D Wu, X Wu, H Chen, Y Hao, W Hu, Z Yang Discovery of chalcone analogues as novel NLRP3 inflammasome inhibitors with potent anti-inflammation activities European Journal of Medicinal Chemistry, 2021-04-01;219(0):113417. 2021-04-01 [PMID: 33845232] (Western Blot, Mouse)
• A Shimada, S Hasegawa-I Increased cytokine expression in the choroid plexus stroma and epithelium in response to endotoxin-induced systemic inflammation in mice Toxicology reports, 2021-03-10;8(0):520-528. 2021-03-10 [PMID: 33747797] (IHC, Mouse)
• MN Lee, Y Lee, D Wu, M Pae Luteolin inhibits NLRP3 inflammasome activation via blocking ASC oligomerization The Journal of nutritional biochemistry, 2021-03-08;0(0):108614. 2021-03-08 [PMID: 33705947] (Western Blot, Mouse)
• Z Li, Y Cao, Y Li, Y Zhao, X Chen Vaccine delivery alerts innate immune systems for more immunogenic vaccination JCI Insight, 2021-04-08;0(0):. 2021-04-08 [PMID: 33690222] (Western Blot, Mouse)
• J Li, H Zhang, Y Dong, X Wang, G Wang Omega-3FAs Can Inhibit the Inflammation and Insulin Resistance of Adipose Tissue Caused by HHcy Induced Lipids Profile Changing in Mice Frontiers in Physiology, 2021-02-12;12(0):628122. 2021-02-12 [PMID: 33643070] (Western Blot, Mouse)
• Y Mishima, T Osaki, A Shimada, S Kamiya, S Hasegawa-I Sex-dependent differences in the gut microbiota following chronic nasal inflammation in adult mice Scientific Reports, 2021-02-25;11(1):4640. 2021-02-25 [PMID: 33633180] (IHC, Mouse)
• Y Shi, Q Lv, M Zheng, H Sun, F Shi NLRP3 inflammasome inhibitor INF39 attenuated NLRP3 assembly in macrophages International immunopharmacology, 2021-01-25;92(0):107358. 2021-01-25 [PMID: 33508701] (ICC, Western Blot, Mouse)
• S Estfanous, K Krause, MNK Anne, M Eltobgy, K Caution, A Abu Khweek, K Hamilton, A Badr, K Daily, C Carafice, D Baetzhold, X Zhang, T Li, H Wen, MA Gavrilin, H Haffez, S Soror, AO Amer Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo Scientific Reports, 2021-01-13;11(1):855. 2021-01-13 [PMID: 33441602] (Western Blot, Mouse)
• Q Lin, S Li, N Jiang, H Jin, X Shao, X Zhu, J Wu, M Zhang, Z Zhang, J Shen, W Zhou, L Gu, R Lu, Z Ni Inhibiting NLRP3 inflammasome attenuates apoptosis in contrast-induced acute kidney injury through the upregulation of HIF1A and BNIP3-mediated mitophagy Autophagy, 2020-12-19;0(0):1-16. 2020-12-19 [PMID: 33345685] (Western Blot, Mouse)
• B Nógrádi, Á Nyúl-Tóth, M Kozma, K Molnár, R Patai, L Siklós, I Wilhelm, IA Krizbai Upregulation of Nucleotide-Binding Oligomerization Domain-, LRR- and Pyrin Domain-Containing Protein 3 in Motoneurons Following Peripheral Nerve Injury in Mice Frontiers in Pharmacology, 2020-11-26;11(0):584184. 2020-11-26 [PMID: 33328988] (Western Blot, Mouse)
• J Nilsson, M Hörnberg, A Schmidt-Ch, K Linde, M Nilsson, M Carlus, SF Erttmann, S Mayans, D Holmberg NKT cells promote both type 1 and type 2 inflammatory responses in a mouse model of liver fibrosis Scientific Reports, 2020-12-11;10(1):21778. 2020-12-11 [PMID: 33311540] (Western Blot, Mouse)
• W Wang, D Hu, Y Feng, C Wu, Y Song, W Liu, A Li, Y Wang, K Chen, M Tian, F Xiao, Q Zhang, W Chen, P Pan, P Wan, Y Liu, H Lan, K Wu, J Wu Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome BMC Biol, 2020-11-26;18(1):182. 2020-11-26 [PMID: 33243234] (Western Blot, Human)
• DR Sweet, NT Vasudevan, L Fan, CE Booth, KS Keerthy, X Liao, V Vinayachan, Y Takami, D Tugal, N Sharma, ER Chan, L Zhang, Y Qing, SL Gerson, C Fu, A Wynshaw-Bo, P Sangwung, L Nayak, P Holvoet, K Matoba, Y Lu, G Zhou, MK Jain Myeloid Kr�ppel-like factor 2 is a critical regulator of metabolic inflammation Nat Commun, 2020-11-18;11(1):5872. 2020-11-18 [PMID: 33208733] (Western Blot, Mouse)
• R Kajino-Sak, T Fujishita, MM Taketo, M Aoki Synthetic lethality between MyD88 loss and mutations in Wnt/&amp;beta-catenin pathway in intestinal tumor epithelial cells Oncogene, 2020-11-12;0(0):. 2020-11-12 [PMID: 33177648] (In Vivo, Mouse)
• H Ahn, GS Lee Riboflavin, vitamin B2, attenuates NLRP3, NLRC4, AIM2, and non-canonical inflammasomes by the inhibition of caspase-1 activity Sci Rep, 2020-11-05;10(1):19091. 2020-11-05 [PMID: 33154451] (Western Blot, Human)
• T Matsuoka, G Yoshimatsu, N Sakata, R Kawakami, T Tanaka, T Yamada, Y Yoshida, S Hasegawa, S Kodama Inhibition of NLRP3 inflammasome by MCC950 improves the metabolic outcome of islet transplantation by suppressing IL-1&amp;beta and islet cellular death Sci Rep, 2020-10-21;10(1):17920. 2020-10-21 [PMID: 33087823] (IHC, Mouse)
• YH Kim, MS Kwak, B Lee, JM Shin, S Aum, IH Park, MG Lee, JS Shin Secretory autophagy machinery and vesicular trafficking are involved in HMGB1 secretion Autophagy, 2020-10-05;0(0):1-18. 2020-10-05 [PMID: 33017561] (Western Blot, Mouse)
• Q Zhao, Y Bi, J Guo, YX Liu, J Zhong, LR Pan, Y Tan, XJ Yu Pristimerin protects against inflammation and metabolic disorder in mice through inhibition of NLRP3 inflammasome activation Acta Pharmacol Sin, 2020-09-28;0(0):. 2020-09-28 [PMID: 32989235] (Immunoprecipitation, Western Blot, Mouse)
• A Volchuk, A Ye, L Chi, BE Steinberg, NM Goldenberg Indirect regulation of HMGB1 release by gasdermin D Nat Commun, 2020-09-11;11(1):4561. 2020-09-11 [PMID: 32917873] (Western Blot, Mouse)
• TM Tucey, J Verma, FAB Olivier, TL Lo, AAB Robertson, T Naderer, A Traven Metabolic competition between host and pathogen dictates inflammasome responses to fungal infection PLoS Pathog., 2020-08-04;16(8):e1008695. 2020-08-04 [PMID: 32750090] (Western Blot, Human, Mouse)
• KM von Herrma, FL Anderson, EM Martinez, AL Young, MC Havrda Slc6a3-dependent expression of a CAPS-associated Nlrp3 allele results in progressive behavioral abnormalities and neuroinflammation in aging mice J Neuroinflammation, 2020-07-17;17(1):213. 2020-07-17 [PMID: 32680528] (IHC, Mouse)
• YH Park, EF Remmers, W Lee, AK Ombrello, LK Chung, Z Shilei, DL Stone, MI Ivanov, NA Loeven, KS Barron, P Hoffmann, M Nehrebecky, YZ Akkaya-Ulu, E Sag, B Balci-Peyn, I Aksentijev, A Gül, CN Rotimi, H Chen, JB Bliska, S Ozen, DL Kastner, D Shriner, JJ Chae Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis Nat. Immunol., 2020-06-29;0(0):. 2020-06-29 [PMID: 32601469] (Western Blot, Mouse)
• K Bulek, J Zhao, Y Liao, N Rana, D Corridoni, A Antanavici, X Chen, H Wang, W Qian, WA Miller-Lit, S Swaidani, F Tang, BB Willard, K McCrae, Z Kang, GR Dubyak, F Cominelli, A Simmons, TT Pizarro, X Li Epithelial-derived gasdermin D mediates nonlytic IL-1&amp;beta release during experimental colitis J. Clin. Invest., 2020-08-03;0(0):. 2020-08-03 [PMID: 32597834] (IP, Human)
• Y Huang, H Wang, Y Hao, H Lin, M Dong, J Ye, L Song, Y Wang, Q Li, B Shan, Y Jiang, H Li, Z Shao, G Kroemer, H Zhang, L Bai, T Jin, C Wang, Y Ma, Y Cai, C Ding, S Liu, Y Pan, W Jiang, R Zhou Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity Nat. Cell Biol., 2020-05-04;0(0):. 2020-05-04 [PMID: 32367047] (Bioassay, Mouse)
• S Xiong, Z Hong, LS Huang, Y Tsukasaki, S Nepal, A Di, M Zhong, W Wu, Z Ye, X Gao, GN Rao, D Mehta, J Rehman, AB Malik IL-1beta suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury J. Clin. Invest., 2020-07-01;130(7):3684-3698. 2020-07-01 [PMID: 32298238] (Immunoprecipitation, Western Blot, Mouse)
• Y Wang, H Li, F Li ELMO2 association with G&amp;alphai2 regulates pancreatic cancer cell chemotaxis and metastasis PeerJ, 2020-04-06;8(0):e8910. 2020-04-06 [PMID: 32292657] (Western Blot, Mouse)
• CA Donado, AB Cao, DP Simmons, BA Croker, PJ Brennan, MB Brenner A Two-Cell Model for IL-1&amp;beta Release Mediated by Death-Receptor Signaling Cell Rep, 2020-04-07;31(1):107466. 2020-04-07 [PMID: 32268091] (Western Blot, Mouse)
• F Cao, X Tian, Z Li, Y Lv, J Han, R Zhuang, B Cheng, Y Gong, B Ying, S Jin, Y Gao Suppression of NLRP3 Inflammasome by Erythropoietin via the EPOR/JAK2/STAT3 Pathway Contributes to Attenuation of Acute Lung Injury in Mice Front Pharmacol, 2020-03-19;11(0):306. 2020-03-19 [PMID: 32265704] (Western Blot, Mouse)
• H Tozaki-Sai, I Sasaki, T Yamashita, M Hosoi, TA Kato, M Tsuda Involvement of exchange protein directly activated by cAMP and tumor progression locus 2 in IL-1&amp;beta production in microglial cells following activation of &amp;beta-adrenergic receptors J. Pharmacol. Sci., 2020-03-21;0(0):. 2020-03-21 [PMID: 32253104] (Western Blot, Mouse)
• S Hamarsheh, L Osswald, BS Saller, S Unger, D De Feo, JM Vinnakota, M Konantz, FM Uhl, H Becker, M Lübbert, K Shoumariye, C Schürch, G Andrieux, N Venhoff, A Schmitt-Gr, S Duquesne, D Pfeifer, MA Cooper, C Lengerke, M Boerries, J Duyster, CM Niemeyer, M Erlacher, BR Blazar, B Becher, O Gro beta , T Brummer, R Zeiser Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation Nat Commun, 2020-04-03;11(1):1659. 2020-04-03 [PMID: 32246016] (Western Blot, Mouse)
• Q Li, Y Cao, C Dang, B Han, R Han, H Ma, J Hao, L Wang Inhibition of double-strand DNA-sensing cGAS ameliorates brain injury after ischemic stroke EMBO Mol Med, 2020-04-01;12(4):e11002. 2020-04-01 [PMID: 32239625] (IHC, Mouse)
• BR Kim, BJ Kim, YH Kook, BJ Kim Mycobacterium abscessus infection leads to enhanced production of type 1 interferon and NLRP3 inflammasome activation in murine macrophages via mitochondrial oxidative stress PLoS Pathog., 2020-03-25;16(3):e1008294. 2020-03-25 [PMID: 32210476] (Neutralization, Mouse)
• R Nakata, Y Nakamura, S Hosomi, H Okuda, Y Nishida, N Sugita, S Itani, Y Nadatani, K Otani, F Tanaka, N Kamata, K Taira, Y Nagami, T Tanigawa, T Watanabe, H Yamagami, T Nakanishi, Y Fujiwara Slco2a1 deficiency exacerbates experimental colitis via inflammasome activation in macrophages: a possible mechanism of chronic enteropathy associated with SLCO2A1 gene Sci Rep, 2020-03-17;10(1):4883. 2020-03-17 [PMID: 32184453] (Western Blot, Mouse)
• S Subbarao, J Sanchez-Ga, N Krishnan, AR Shenoy, BD Robertson Genetic and pharmacological inhibition of inflammasomes reduces the survival of Mycobacterium tuberculosis strains in macrophages Sci Rep, 2020-02-28;10(1):3709. 2020-02-28 [PMID: 32111888] (Western Blot, Mouse)
• Z Zas?ona, E Flis, MM Wilk, RG Carroll, EM Palsson-Mc, MM Hughes, C Diskin, K Banahan, DG Ryan, A Hooftman, A Misiak, J Kearney, G Lochnit, W Bertrams, T Greulich, B Schmeck, OJ McElvaney, KHG Mills, EC Lavelle, M Wygrecka, EM Creagh, LAJ O'Neill Caspase-11 promotes allergic airway inflammation Nat Commun, 2020-02-26;11(1):1055. 2020-02-26 [PMID: 32103022] (Western Blot, Human)
• K Das Gupta, MR Shakespear, JEB Curson, AMV Murthy, A Iyer, MP Hodson, D Ramnath, VA Tillu, JB von Pein, RC Reid, K Tunny, DM Hohenhaus, SV Moradi, GM Kelly, T Kobayashi, JH Gunter, AJ Stevenson, W Xu, L Luo, A Jones, WA Johnston, A Blumenthal, K Alexandrov, BM Collins, JL Stow, DP Fairlie, MJ Sweet Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2 Cell Rep, 2020-02-25;30(8):2712-2728.e8. 2020-02-25 [PMID: 32101747] (Western Blot, Mouse)
• B Liu, Y Lu, X Chen, PG Muthuraj, X Li, M Pattabiram, J Zempleni, SD Kachman, SK Natarajan, J Yu Protective Role of Shiitake Mushroom-Derived Exosome-Like Nanoparticles in D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice Nutrients, 2020-02-13;12(2):. 2020-02-13 [PMID: 32069862] (Western Blot, Mouse)
• Y Wooff, N Fernando, JHC Wong, C Dietrich, R Aggio-Bruc, JA Chu-Tan, AAB Robertson, SL Doyle, SM Man, R Natoli Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration Sci Rep, 2020-02-10;10(1):2263. 2020-02-10 [PMID: 32041990] (IHC, Western Blot, Mouse)
• D Fox, A Mathur, Y Xue, Y Liu, WH Tan, S Feng, A Pandey, C Ngo, JA Hayward, II Atmosukart, JD Price, MD Johnson, N Jessberger, AAB Robertson, G Burgio, DC Tscharke, EM Fox, DL Leyton, NO Kaakoush, E Märtlbauer, SH Leppla, SM Man Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome Nat Commun, 2020-02-06;11(1):760. 2020-02-06 [PMID: 32029733] (Western Blot, Mouse)
• J Wang, H Liu, G Xie, W Cai, J Xu Identification of hub genes and key pathways of dietary advanced glycation end products?induced non?alcoholic fatty liver disease by bioinformatics analysis and animal experiments Mol Med Rep, 2019-12-09;21(2):685-694. 2019-12-09 [PMID: 31974594] (IHC, Mouse)
• J Kim, H Ahn, S Yu, JH Ahn, HJ Ko, MN Kweon, EJ Hong, BS An, E Lee, GS Lee I&amp;kappaB? controls NLRP3 inflammasome activation via upregulation of the Nlrp3 gene Cytokine, 2020-01-07;127(0):154983. 2020-01-07 [PMID: 31918161] (Western Blot, Mouse)
• A Bhatta, M Atianand, Z Jiang, J Crabtree, J Blin, KA Fitzgerald A Mitochondrial Micropeptide Is Required for Activation of the Nlrp3 Inflammasome J. Immunol., 2019-12-13;0(0):. 2019-12-13 [PMID: 31836654] (Western Blot, Mouse)
• M Speir, CJ Nowell, AA Chen, JA O'Donnell, IS Shamie, PR Lakin, AA D'Cruz, RO Braun, JJ Babon, RS Lewis, M Bliss-More, I Shlomovitz, S Wang, LH Cengia, AI Stoica, R Hakem, MA Kelliher, LA O'Reilly, H Patsiouras, KE Lawlor, E Weller, NE Lewis, AW Roberts, M Gerlic, BA Croker Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation Nat. Immunol., 2019-12-09;21(1):54-64. 2019-12-09 [PMID: 31819256] (Western Blot, Mouse)
• M Di Gioia, R Spreafico, JR Springstea, MM Mendelson, R Joehanes, D Levy, I Zanoni Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation Nat. Immunol., 2019-11-25;0(0):. 2019-11-25 [PMID: 31768073] (Western Blot, Mouse)
• T Yoshizaki, S Itoh, S Yamaguchi, T Numata, A Nambu, N Kimura, H Suto, K Okumura, K Sudo, A Yamaguchi, S Nakae IL-25 exacerbates autoimmune aortitis in IL-1 receptor antagonist-deficient mice Sci Rep, 2019-11-19;9(1):17067. 2019-11-19 [PMID: 31745167] (IHC, Mouse)
• Y Chen, H Wang, J Shen, R Deng, X Yao, Q Guo, A Lu, B Sun, Y Zhang, G Meng Gasdermin D Drives the Nonexosomal Secretion of Galectin-3, an Insulin Signal Antagonist J. Immunol., 2019-10-09;0(0):. 2019-10-09 [PMID: 31597705] (Western Blot, Mouse)
• MM Hughes, A Hooftman, S Angiari, P Tummala, Z Zaslona, MC Runtsch, AF McGettrick, CE Sutton, C Diskin, M Rooke, S Takahashi, S Sundararaj, MG Casarotto, JE Dahlstrom, EM Palsson-Mc, SC Corr, KHG Mills, RJS Preston, N Neamati, Y Xie, JB Baell, PG Board, LAJ O'Neill Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation Cell Rep, 2019-10-01;29(1):151-161.e5. 2019-10-01 [PMID: 31577945] (Western Blot, Mouse)
• P Wang, X Qi, G Xu, J Liu, J Guo, X Li, X Ma, H Sun CCL28 promotes locomotor recovery after spinal cord injury via recruiting regulatory T cells Aging (Albany NY), 2019-09-26;11(18):7402-7415. 2019-09-26 [PMID: 31557129] (Neutralization, Mouse)
• P Samir, S Kesavardha, DM Patmore, S Gingras, RKS Malireddi, R Karki, CS Guy, B Briard, DE Place, A Bhattachar, BR Sharma, A Nourse, SV King, A Pitre, AR Burton, S Pelletier, RJ Gilbertson, TD Kanneganti DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome Nature, 2019-09-11;0(0):. 2019-09-11 [PMID: 31511697] (Western Blot, Mouse)
• MK Akula, MX Ibrahim, EG Ivarsson, OM Khan, IT Kumar, M Erlandsson, C Karlsson, X Xu, M Brisslert, C Brakebusch, D Wang, M Bokarewa, VI Sayin, MO Bergo Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions Nat Commun, 2019-09-04;10(1):3975. 2019-09-04 [PMID: 31484924] (Western Blot, Mouse)
• Mian Wu, M Zhang, Y Ma, F Liu, S Chen, J Lu, H Chen Chaetocin attenuates gout in mice through inhibiting HIF-1? and NLRP3 inflammasome-dependent IL-1? secretion in macrophages Arch. Biochem. Biophys., 2019-06-28;0(0):. 2019-06-28 [PMID: 31255694] (Western Blot, Mouse)
• Q Lin, S Li, N Jiang, X Shao, M Zhang, H Jin, Z Zhang, J Shen, Y Zhou, W Zhou, L Gu, R Lu, Z Ni PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation Redox Biol, 2019-06-11;26(0):101254. 2019-06-11 [PMID: 31229841] (IHC, Mouse)
• MR Spalinger, TS Schmidt, M Schwarzfis, L Hering, K Atrott, S Lang, C Gottier, A Geirnaert, C Lacroix, X Dai, DJ Rawlings, AC Chan, C von Mering, G Rogler, M Scharl Protein tyrosine phosphatase non-receptor type 22 modulates colitis in a microbiota-dependent manner J. Clin. Invest., 2019-05-20;130(0):2527-2541. 2019-05-20 [PMID: 31107248] (Western Blot, Mouse)
• LS da Costa, A Outlioua, A Anginot, K Akarid, D Arnoult RNA viruses promote activation of the NLRP3 inflammasome through cytopathogenic effect-induced potassium efflux Cell Death Dis, 2019-04-25;10(5):346. 2019-04-25 [PMID: 31024004] (Western Blot, Mouse)
• DM Ojcius, A Jafari, L Yeruva, CW Schindler, AA Abdul-Sate Dicer regulates activation of the NLRP3 inflammasome PLoS ONE, 2019-04-23;14(4):e0215689. 2019-04-23 [PMID: 31013297] (Western Blot, Mouse)
• R Meng, L Gu, Y Lu, K Zhao, J Wu, H Wang, J Han, Y Tang, B Lu High mobility group box 1 enables bacterial lipids to trigger receptor-interacting protein kinase 3 (RIPK3)-mediated necroptosis and apoptosis in mice J. Biol. Chem., 2019-04-18;0(0):. 2019-04-18 [PMID: 31000631] (Western Blot, Mouse)
• H Ahn, BC Han, J Kim, SG Kang, PH Kim, KH Jang, SH So, SH Lee, GS Lee Nonsaponin fraction of Korean Red Ginseng attenuates cytokine production via inhibition of TLR4 expression J Ginseng Res, 2018-04-04;43(2):291-299. 2018-04-04 [PMID: 30976167] (Western Blot, Mouse)
• P Zhang, L Cao, R Zhou, X Yang, M Wu The lncRNA Neat1 promotes activation of inflammasomes in macrophages Nat Commun, 2019-04-02;10(1):1495. 2019-04-02 [PMID: 30940803] (Western Blot, Mouse)
• VS Tapia, MJD Daniels, P Palazón-Ri, M Dewhurst, NM Luheshi, J Rivers-Aut, J Green, E Redondo-Ca, P Kaldis, G Lopez-Cast, D Brough The three cytokines IL-1?, IL-18, and IL-1? share related but distinct secretory routes J. Biol. Chem., 2019-04-02;294(21):8325-8335. 2019-04-02 [PMID: 30940725] (Western Blot, Mouse)
• J Lee, E Jung, M Heur Injury induces endothelial to mesenchymal transition in the mouse corneal endothelium in vivo via FGF2 Mol. Vis., 2019-01-20;25(0):22-34. 2019-01-20 [PMID: 30804659] (Western Blot, Mouse)
• S Morita-Tak, K Nakahara, S Hasegawa-I, A Isonishi, K Tatsumi, H Okuda, T Tanaka, M Kitabatake, T Ito, A Wanaka Responses of perivascular macrophages to circulating lipopolysaccharides in the subfornical organ with special reference to endotoxin tolerance J Neuroinflammation, 2019-02-14;16(1):39. 2019-02-14 [PMID: 30764851] (IHC-Fr, Mouse)
• Z Erlich, I Shlomovitz, L Edry-Botze, H Cohen, D Frank, H Wang, AM Lew, KE Lawlor, Y Zhan, JE Vince, M Gerlic Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model Nat. Immunol., 2019-02-11;0(0):. 2019-02-11 [PMID: 30742078] (Western Blot, Mouse)
• WL Hwang, HY Lan, WC Cheng, SC Huang, MH Yang Tumor stem-like cell-derived exosomal RNAs prime neutrophils for facilitating tumorigenesis of colon cancer J Hematol Oncol, 2019-01-25;12(1):10. 2019-01-25 [PMID: 30683126] (Neutralization, Mouse)
• H Cui, S Banerjee, S Guo, N Xie, J Ge, D Jiang, M Zörnig, VJ Thannickal, G Liu Long noncoding RNA Malat1 regulates differential activation of macrophage and response to lung injury JCI Insight, 2019-02-21;0(0):. 2019-02-21 [PMID: 30676324] (Western Blot, Mouse)
• RT Gunaratna, A Santos, L Luo, C Nagi, I Lambertz, M Spier, CJ Conti, RS Fuchs-Youn Dynamic role of the codon 72 p53 single-nucleotide polymorphism in mammary tumorigenesis in a humanized mouse model Oncogene, 2019-01-16;0(0):. 2019-01-16 [PMID: 30651598] (IHC-P, Mouse)
• D Kurundkar, AR Kurundkar, NB Bone, EJ Becker, W Liu, B Chacko, V Darley-Usm, JW Zmijewski, VJ Thannickal SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury JCI Insight, 2019-01-10;4(1):. 2019-01-10 [PMID: 30626741] (Western Blot, Mouse)
• C Widmann, C Gandin, A Petit-Pait, M Lazdunski, C Heurteaux The Traditional Chinese Medicine MLC901 inhibits inflammation processes after focal cerebral ischemia Sci Rep, 2018-12-24;8(1):18062. 2018-12-24 [PMID: 30584250] (IHC, Mouse)
• A Mathur, S Feng, JA Hayward, C Ngo, D Fox, II Atmosukart, JD Price, K Schauer, E Märtlbauer, AAB Robertson, G Burgio, EM Fox, SH Leppla, NO Kaakoush, SM Man A multicomponent toxin from Bacillus cereus incites inflammation and shapes host outcome via the NLRP3 inflammasome Nat Microbiol, 2018-12-10;0(0):. 2018-12-10 [PMID: 30531979] (Western Blot, Mouse)
• JE Vince, D De Nardo, W Gao, AJ Vince, C Hall, K McArthur, D Simpson, S Vijayaraj, LM Lindqvist, P Bouillet, MA Rizzacasa, SM Man, J Silke, SL Masters, G Lessene, DCS Huang, DHD Gray, BT Kile, F Shao, KE Lawlor The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1? Activation Cell Rep, 2018-11-27;25(9):2339-2353.e4. 2018-11-27 [PMID: 30485804] (Western Blot, Mouse)
• B Koch, AA Barugahare, TL Lo, C Huang, RB Schittenhe, DR Powell, TH Beilharz, A Traven A Metabolic Checkpoint for the Yeast-to-Hyphae Developmental Switch Regulated by Endogenous Nitric Oxide Signaling Cell Rep, 2018-11-20;25(8):2244-2258.e7. 2018-11-20 [PMID: 30463019] (Western Blot, Mouse)
• D Sharma, A Malik, C Guy, P Vogel, TD Kanneganti TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy J. Clin. Invest., 2018-11-19;0(0):. 2018-11-19 [PMID: 30457980] (Western Blot, Mouse)
• L Kasper, A König, PA Koenig, MS Gresnigt, J Westman, RA Drummond, MS Lionakis, O Gro beta , J Ruland, JR Naglik, B Hube The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes Nat Commun, 2018-10-15;9(1):4260. 2018-10-15 [PMID: 30323213]
• S Wang, Y Lin, X Yuan, F Li, L Guo, B Wu REV-ERB? integrates colon clock with experimental colitis through regulation of NF-?B/NLRP3 axis Nat Commun, 2018-10-12;9(1):4246. 2018-10-12 [PMID: 30315268] (Western Blot, Mouse)
• JT Benjamin, DJ Moore, C Bennett, R van der Me, A Royce, R Loveland, JL Wynn Cutting Edge: IL-1? and Not IL-1? Drives IL-1R1-Dependent Neonatal Murine Sepsis Lethality J. Immunol., 2018-10-10;0(0):. 2018-10-10 [PMID: 30305325] (Western Blot, Mouse)
• Z Zhang, X Shao, N Jiang, S Mou, L Gu, S Li, Q Lin, Y He, M Zhang, W Zhou, Z Ni Caspase-11-mediated tubular epithelial pyroptosis underlies contrast-induced acute kidney injury Cell Death Dis, 2018-09-24;9(10):983. 2018-09-24 [PMID: 30250284] (IHC-P, Mouse)
• Y Chen, X He, X Yuan, J Hong, O Bhat, G Li, PL Li, J Guo NLRP3 Inflammasome Formation and Activation in Nonalcoholic Steatohepatitis: Therapeutic Target for Antimetabolic Syndrome Remedy FTZ Oxid Med Cell Longev, 2018-07-22;2018(0):2901871. 2018-07-22 [PMID: 30140364] (IHC, Mouse)
• M Monteleone, AC Stanley, KW Chen, DL Brown, JS Bezbradica, JB von Pein, CL Holley, D Boucher, MR Shakespear, R Kapetanovi, V Rolfes, MJ Sweet, JL Stow, K Schroder Interleukin-1? Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion Cell Rep, 2018-08-07;24(6):1425-1433. 2018-08-07 [PMID: 30089254] (ICC, Mouse)
• C Marchetti, B Swartzwelt, MI Koenders, T Azam, IW Tengesdal, N Powers, DM de Graaf, CA Dinarello, LAB Joosten NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis Arthritis Res. Ther., 2018-08-03;20(1):169. 2018-08-03 [PMID: 30075804] (Western Blot, Mouse)
• M Shahid, MY Lee, A Yeon, E Cho, V Sairam, L Valdiviez, S You, J Kim Menthol, a unique urinary volatile compound, is associated with chronic inflammation in interstitial cystitis Sci Rep, 2018-07-18;8(1):10859. 2018-07-18 [PMID: 30022124] (Western Blot, Mouse)
• H He, H Jiang, Y Chen, J Ye, A Wang, C Wang, Q Liu, G Liang, X Deng, W Jiang, R Zhou Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity Nat Commun, 2018-06-29;9(1):2550. 2018-06-29 [PMID: 29959312] (Western Blot, Mouse)
• E Lee, I Hwang, S Park, S Hong, B Hwang, Y Cho, J Son, JW Yu MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration Cell Death Differ., 2018-05-21;0(0):. 2018-05-21 [PMID: 29786072] (Western Blot, Mouse)
• SB Kwak, S Koppula, EJ In, X Sun, YK Kim, MK Kim, KH Lee, TB Kang Artemisia Extract Suppresses NLRP3 and AIM2 Inflammasome Activation by Inhibition of ASC Phosphorylation Mediators Inflamm., 2018-03-04;2018(0):6054069. 2018-03-04 [PMID: 29686531] (Western Blot, Mouse)
• LG Coleman, R Maile, SW Jones, BA Cairns, FT Crews HMGB1/IL-1? complexes in plasma microvesicles modulate immune responses to burn injury PLoS ONE, 2018-03-30;13(3):e0195335. 2018-03-30 [PMID: 29601597] (Western Blot, Mouse)
• YK Kim, S Koppula, DW Shim, EJ In, SB Kwak, MK Kim, SH Yu, KH Lee, TB Kang Inhibitory Effect and Mechanism ofArctium lappaExtracton NLRP3Inflammasome Activation Evid Based Complement Alternat Med, 2018-01-18;2018(0):6346734. 2018-01-18 [PMID: 29576797] (Western Blot, Mouse)
• C Cochain, E Vafadarnej, P Arampatzi, P Jaroslav, H Winkels, K Ley, D Wolf, AE Saliba, A Zernecke Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine Atherosclerosis Circ. Res., 2018-03-15;0(0):. 2018-03-15 [PMID: 29545365] (IHC, Mouse)
• Y Huang, H Jiang, Y Chen, X Wang, Y Yang, J Tao, X Deng, G Liang, H Zhang, W Jiang, R Zhou Tranilast directly targets NLRP3 to treat inflammasome-driven diseases EMBO Mol Med, 2018-04-01;0(0):. 2018-04-01 [PMID: 29531021] (Western Blot, Mouse)
• LH Chu, M Indramohan, RA Ratsimandr, A Gangopadhy, EP Morris, DM Monack, A Dorfleutne, C Stehlik The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages Nat Commun, 2018-03-08;9(1):996. 2018-03-08 [PMID: 29520027] (Western Blot, Mouse)
• W Zhuang, C Wang, X Shi, S Qiu, S Zhang, B Xu, M Chen, W Jiang, H Dong, Y Qiao MCMV triggers ROS/NLRP3-associated inflammasome activation in the inner ear of mice and cultured spiral ganglion neurons, contributing to sensorineural hearing loss Int. J. Mol. Med., 2018-03-06;0(0):. 2018-03-06 [PMID: 29512778] (Western Blot, Mouse)
• RG Carroll, Z Zas?ona, S Galván-Peñ, EL Koppe, DC Sévin, S Angiari, M Triantafil, K Triantafil, LK Modis, LA O'Neill An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation J. Biol. Chem., 2018-02-20;293(15):5509-5521. 2018-02-20 [PMID: 29463677] (Western Blot, Mouse)
• JC Santos, MS Dick, B Lagrange, D Degrandi, K Pfeffer, M Yamamoto, E Meunier, P Pelczar, T Henry, P Broz LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation EMBO J., 2018-02-19;0(0):. 2018-02-19 [PMID: 29459437] (Western Blot, Mouse)
• D Boucher, M Monteleone, RC Coll, KW Chen, CM Ross, JL Teo, GA Gomez, CL Holley, D Bierschenk, KJ Stacey, AS Yap, JS Bezbradica, K Schroder Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity J. Exp. Med., 2018-02-06;0(0):. 2018-02-06 [PMID: 29432122] (Western Blot, Mouse)
• JL Ross, LF Queme, JE Lamb, KJ Green, MP Jankowski Sex differences in primary muscle afferent sensitization following ischemia and reperfusion injury Biol Sex Differ, 2018-01-03;9(1):2. 2018-01-03 [PMID: 29298725] (Western Blot, Mouse)
• K Zenke, M Muroi, KI Tanamoto AKT1 distinctively suppresses MyD88-depenedent and TRIF-dependent Toll-like receptor signaling in a kinase activity-independent manner Cell. Signal., 2017-12-11;43(0):32-39. 2017-12-11 [PMID: 29242168] (Western Blot, Mouse)
• S Ghosh, C Wallerath, S Covarrubia, V Hornung, S Carpenter, KA Fitzgerald The PYHIN Protein p205 Regulates the Inflammasome by Controlling Asc Expression J. Immunol., 2017-09-20;0(0):. 2017-09-20 [PMID: 28931603] (Western Blot, Mouse)
• JC Rivera, B Noueihed, A Madaan, I Lahaie, J Pan, J Belik, S Chemtob Tetrahydrobiopterin (BH4) deficiency is associated with augmented inflammation and microvascular degeneration in the retina J Neuroinflammation, 2017-09-06;14(1):181. 2017-09-06 [PMID: 28874201] (IHC, Mouse)
• F Albalawi, W Lu, JM Beckel, JC Lim, SA McCaughey, CH Mitchell The P2X7 Receptor Primes IL-1? and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain Front Cell Neurosci, 2017-08-08;11(0):227. 2017-08-08 [PMID: 28848393] (IHC, Western Blot, Mouse)
• EM McDonough, CW Barrett, B Parang, MK Mittal, JJ Smith, AM Bradley, YA Choksi, LA Coburn, SP Short, JJ Thompson, B Zhang, SV Poindexter, MA Fischer, X Chen, J Li, FL Revetta, R Naik, MK Washington, MJ Rosen, SW Hiebert, KT Wilson, CS Williams MTG16 is a tumor suppressor in colitis-associated carcinoma JCI Insight, 2017-08-17;2(16):. 2017-08-17 [PMID: 28814670] (IHC, Mouse)
• B Brawek, Y Liang, D Savitska, K Li, N Fomin-Thun, Y Kovalchuk, E Zirdum, J Jakobsson, O Garaschuk A new approach for ratiometric in vivo calcium imaging of microglia Sci Rep, 2017-07-20;7(1):6030. 2017-07-20 [PMID: 28729628] (IHC, Mouse)
• S Yoon, A Kovalenko, K Bogdanov, D Wallach MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation Immunity, 2017-06-27;0(0):. 2017-06-27 [PMID: 28666573] (Western Blot, Mouse)
• T Wu, J Zhang, M Geng, SJ Tang, W Zhang, J Shu Nucleoside reverse transcriptase inhibitors (NRTIs) induce proinflammatory cytokines in the CNS via Wnt5a signaling Sci Rep, 2017-06-23;7(1):4117. 2017-06-23 [PMID: 28646196] (Western Blot, Mouse)
• R Domingo-Fe, RC Coll, J Kearney, S Breit, LA O'Neill The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1? transcription and activate the NLRP3 inflammasome J. Biol. Chem., 2017-06-02;0(0):. 2017-06-02 [PMID: 28576828] (Western Blot, Mouse)
• V Neudecker, M Haneklaus, O Jensen, L Khailova, JC Masterson, H Tye, K Biette, P Jedlicka, KS Brodsky, ME Gerich, M Mack, AAB Robertson, MA Cooper, GT Furuta, CA Dinarello, LA O'Neill, HK Eltzschig, SL Masters, EN McNamee Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome J. Exp. Med., 2017-05-09;0(0):. 2017-05-09 [PMID: 28487310] (Western Blot, Mouse)
• Q Zhu, TD Kanneganti Cutting Edge: Distinct Regulatory Mechanisms Control Proinflammatory Cytokines IL-18 and IL-1? J. Immunol., 2017-05-03;0(0):. 2017-05-03 [PMID: 28468974] (Western Blot, Mouse)
• H Ahn, E Jeon, JC Kim, SG Kang, SI Yoon, HJ Ko, PH Kim, GS Lee Lentinan from shiitake selectively attenuates AIM2 and non-canonical inflammasome activation while inducing pro-inflammatory cytokine production Sci Rep, 2017-05-02;7(1):1314. 2017-05-02 [PMID: 28465544] (Western Blot, Mouse)
• Y Kanamori, M Murakami, M Sugiyama, O Hashimoto, T Matsui, M Funaba IL-1? transcriptionally activates hepcidin by inducing C/EBP? expression in hepatocytes J. Biol. Chem., 2017-04-24;0(0):. 2017-04-24 [PMID: 28438835] (IHC, Mouse)
• L Freeman, H Guo, CN David, WJ Brickey, S Jha, JP Ting NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes J. Exp. Med., 2017-04-12;0(0):. 2017-04-12 [PMID: 28404595] (Western Blot, Mouse)
• MK Choo, Y Sano, C Kim, K Yasuda, XD Li, X Lin, M Stenzel-Po, L Alexopoulo, S Ghosh, E Latz, IR Rifkin, ZJ Chen, GC Stewart, H Chong, JM Park TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects J. Exp. Med., 2017-04-11;214(5):1297-1311. 2017-04-11 [PMID: 28400473] (Western Blot, Mouse)
• Z Zhong, Y Zhai, P Bu, S Shah, L Qiao Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of Apc(Min/+) mice Nat Commun, 2017-04-11;8(0):15004. 2017-04-11 [PMID: 28397782] (Western Blot, Mouse)
• H Youssef, P Stashenko Interleukin-1 and estrogen protect against disseminating dentoalveolar infections Int J Oral Sci, 2017-03-01;9(1):16-23. 2017-03-01 [PMID: 28358036] (Neutralization, Mouse)
• K Moriwaki, S Balaji, J Bertin, PJ Gough, FK Chan Distinct Kinase-Independent Role of RIPK3 in CD11c(+) Mononuclear Phagocytes in Cytokine-Induced Tissue Repair Cell Rep, 2017-03-07;18(10):2441-2451. 2017-03-07 [PMID: 28273458] (Western Blot, Mouse)
• TP Domiciano, D Wakita, HD Jones, TR Crother, WA Verri, M Arditi, K Shimada Quercetin Inhibits Inflammasome Activation by Interfering with ASC Oligomerization and Prevents Interleukin-1 Mediated Mouse Vasculitis Sci Rep, 2017-02-02;7(0):41539. 2017-02-02 [PMID: 28148962] (Western Blot, Mouse)
• M Tsugita, N Morimoto, M Tashiro, K Kinoshita, M Nakayama SR-B1 Is a Silica Receptor that Mediates Canonical Inflammasome Activation Cell Rep, 2017-01-31;18(5):1298-1311. 2017-01-31 [PMID: 28147282] (Western Blot, Mouse)
• O Tufanli, P Telkoparan, D Acosta-Alv, B Kocaturk, UI Onat, SM Hamid, I €imen, P Walter, C Weber, E Erbay Targeting IRE1 with small molecules counteracts progression of atherosclerosis Proc. Natl. Acad. Sci. U.S.A, 2017-01-30;0(0):. 2017-01-30 [PMID: 28137856] (Western Blot, Mouse)
• HJ Koh, YR Kim, JS Kim, JS Yun, K Jang, CS Yang Toxoplasma gondii GRA7-Targeted ASC and PLD1 Promote Antibacterial Host Defense via PKC� PLoS Pathog, 2017-01-26;13(1):e1006126. 2017-01-26 [PMID: 28125719] (Western Blot, Mouse)
• Histone deacetylase inhibitors mediate DNA damage repair in ameliorating hemorrhagic cystitis Sci Rep, 2016-12-20;6(0):39257. 2016-12-20 [PMID: 27995963] (Western Blot, Mouse)
• Functional and Evolutionary Analyses Identify Proteolysis as a General Mechanism for NLRP1 Inflammasome Activation PLoS Pathog, 2016-12-07;12(12):e1006052. 2016-12-07 [PMID: 27926929] (Western Blot, Human)
• TNF?-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury Proc. Natl. Acad. Sci. U.S.A., 2016-11-28;113(50):E8151-E8158. 2016-11-28 [PMID: 27911817] (Western Blot, Mouse)
• Jeremy S Duffield Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury J. Clin. Invest., 2016-11-21;0(0):. 2016-11-21 [PMID: 27869651] (IHC, Western Blot, Mouse)
• CARD9 negatively regulates NLRP3-induced IL-1? production on Salmonella infection of macrophages Nat Commun, 2016-09-27;7(0):12874. 2016-09-27 [PMID: 27670879] (Western Blot, Mouse)
• Lymphatic vessels regulate immune microenvironments in human and murine melanoma J Clin Invest, 2016-08-15;0(0):. 2016-08-15 [PMID: 27525437] (Western Blot, Human)
• CD8+ T cells produce a dialyzable antigen-specific activator of dendritic cells J Leukoc Biol, 2016-08-11;0(0):. 2016-08-11 [PMID: 27515950] (Neutralization, Mouse)
• C13orf31 (FAMIN) is a central regulator of immunometabolic function Nat Immunol, 2016-08-01;0(0):. 2016-08-01 [PMID: 27478939] (Western Blot, Mouse)
• HIF-1? Is an Essential Mediator of IFN-?-Dependent Immunity to Mycobacterium tuberculosis J Immunol, 2016-07-18;0(0):. 2016-07-18 [PMID: 27430718] (Western Blot, Mouse)
• Enzymatically inactive procaspase-1 stabilizes the ASC-pyroptosome and supports pyroptosome spreading during cell division J Biol Chem, 2016-07-08;0(0):. 2016-07-08 [PMID: 27402835] (Bead-based Immunoassay, Mouse)
• Activation of NLRP3 inflammasomes in mouse hepatic stellate cells during Schistosoma J. infection Oncotarget, 2016-06-28;7(26):39316-39331. 2016-06-28 [PMID: 27322427] (IHC, IHC-P, Mouse)
• Yong Hwan Park Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS Nat Immunol, 2016-06-06;0(0):. 2016-06-06 [PMID: 27270401] (Western Blot, Mouse)
• Gang Hu Fluoxetine Inhibits NLRP3 Inflammasome Activation: Implication in Depression Int. J. Neuropsychopharmacol., 2016-09-21;19(9):. 2016-09-21 [PMID: 27207922] (Western Blot, Mouse)
• X Wang, DK Shaw, OS Sakhon, GA Snyder, EJ Sundberg, L Santambrog, FS Sutterwala, JS Dumler, KA Shirey, DJ Perkins, K Richard, AC Chagas, E Calvo, J Kopecký, M Kotsyfakis, JH Pedra The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation Infect Immun, 2016-05-24;0(0):. 2016-05-24 [PMID: 27045038] (Western Blot, Mouse)
• Marty-Roix R, Vladimer G, Pouliot K, Weng D, Buglione-Corbett R, West K, Macmicking J, Chee J, Wang S, Lu S, Lien E Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants. J Biol Chem, 2015-11-10;291(3):1123-36. 2015-11-10 [PMID: 26555265] (Western Blot, Mouse)
• Sester D, Sagulenko V, Thygesen S, Cridland J, Loi Y, Cridland S, Masters S, Genske U, Hornung V, Andoniou C, Sweet M, Degli-Esposti M, Schroder K, Stacey K Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice. J Immunol, 2015-06-26;195(3):1233-41. 2015-06-26 [PMID: 26116505] (Western Blot, Mouse)
• Sadeghi H, Lockmann A, Hund A, Samavedam U, Pipi E, Vafia K, Hauenschild E, Kalies K, Pas H, Jonkman M, Iwata H, Recke A, Schon M, Zillikens D, Schmidt E, Ludwig R Caspase-1-independent IL-1 release mediates blister formation in autoantibody-induced tissue injury through modulation of endothelial adhesion molecules. J Immunol, 2015-03-20;194(8):3656-63. 2015-03-20 [PMID: 25795756] (Western Blot, Mouse)
• Denes A, Coutts G, Lenart N, Cruickshank S, Pelegrin P, Skinner J, Rothwell N, Allan S, Brough D AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3. Proc Natl Acad Sci U S A, 2015-03-16;112(13):4050-5. 2015-03-16 [PMID: 25775556] (IHC-Fr, Mouse)
• Meunier E, Wallet P, Dreier R, Costanzo S, Anton L, Ruhl S, Dussurgey S, Dick M, Kistner A, Rigard M, Degrandi D, Pfeffer K, Yamamoto M, Henry T, Broz P Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida. 2015-03-16;0(0):. 2015-03-16 [PMID: 25774716] (Western Blot, Mouse)
• Chien C, Lee M, Liou H, Liou H, Fu W Local immunosuppressive microenvironment enhances migration of melanoma cells to lungs in DJ-1 knockout mice. PLoS ONE, 2015-02-23;10(2):e0115827. 2015-02-23 [PMID: 25706411] (Neutralization, Mouse)
• Lawlor K, Khan N, Mildenhall A, Gerlic M, Croker B, D'Cruz A, Hall C, Kaur Spall S, Anderton H, Masters S, Rashidi M, Wicks I, Alexander W, Mitsuuchi Y, Benetatos C, Condon S, Wong W, Silke J, Vaux D, Vince J RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL. Nat Commun, 2015-02-18;6(0):6282. 2015-02-18 [PMID: 25693118] (Neutralization, Western Blot, Mouse)
• Maier N, Leppla S, Moayeri M The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes. J Immunol, 2015-02-13;194(6):2776-85. 2015-02-13 [PMID: 25681332] (Western Blot, Mouse)
• Yang C, Kim J, Kim T, Lee P, Kim S, Lee H, Shin D, Nguyen L, Lee M, Jin H, Kim K, Lee C, Kim M, Park S, Kim J, Choi H, Jo E Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome. Nat Commun, 2015-02-06;6(0):6115. 2015-02-06 [PMID: 25655831] (Western Blot, Mouse)
• Li B, Gurung P, Malireddi R, Vogel P, Kanneganti T, Geiger T IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T-cell-mediated colitis. Nat Commun, 2015-01-21;6(0):6131. 2015-01-21 [PMID: 25607885] (IHC, Western Blot, Mouse)
• Moriwaki K, Bertin J, Gough P, Chan F A RIPK3-caspase 8 complex mediates atypical pro-IL-1beta processing. J Immunol, 2015-01-07;194(4):1938-44. 2015-01-07 [PMID: 25567679] (Western Blot, Mouse)
• Sitaras N, Rivera J, Noueihed B, Bien-Aime M, Zaniolo K, Omri S, Hamel D, Zhu T, Hardy P, Sapieha P, Joyal J, Chemtob S Retinal neurons curb inflammation and enhance revascularization in ischemic retinopathies via proteinase-activated receptor-2. Am J Pathol, 2014-12-03;185(2):581-95. 2014-12-03 [PMID: 25478809] (Western Blot, Mouse)
• Ahn H, Kim J, Lee M, Kim Y, Cho Y, Lee G Methylsulfonylmethane inhibits NLRP3 inflammasome activation. Cytokine, 2014-11-21;71(2):223-31. 2014-11-21 [PMID: 25461402] (Western Blot, Mouse)
• Hari A, Zhang Y, Tu Z, Detampel P, Stenner M, Ganguly A, Shi Y Activation of NLRP3 inflammasome by crystalline structures via cell surface contact. Sci Rep, 2014-12-02;4(0):7281. 2014-12-02 [PMID: 25445147] (Western Blot, Mouse)
• Lim , Yu-Mi, Lim , Hyejin, Hur , Kyu Yeon, Quan , Wenying, Lee , Hae-Youn, Cheon , Hwanju, Ryu , Dongryeo, Koo , Seung-Ho, Kim , Hong Lim, Kim , Jin, Komatsu , Masaaki, Lee , Myung-Sh Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes. Nat Commun, 2014-09-26;5(0):4934. 2014-09-26 [PMID: 25255859] (Western Blot, Mouse)
• Ganesan S, Rathinam V, Bossaller L, Army K, Kaiser W, Mocarski E, Dillon C, Green D, Mayadas T, Levitz S, Hise A, Silverman N, Fitzgerald K Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1beta production in response to beta-glucans and the fungal pathogen, Candida albicans. J Immunol, 2014-07-25;193(5):2519-30. 2014-07-25 [PMID: 25063877] (Western Blot, Mouse)
• Asrat S, Dugan A, Isberg R The frustrated host response to Legionella pneumophila is bypassed by MyD88-dependent translation of pro-inflammatory cytokines. PLoS Pathog, 2014-07-24;10(7):e1004229. 2014-07-24 [PMID: 25058342] (Western Blot, Mouse)
• Kajiwara Y, Schiff T, Voloudakis G, Gama Sosa M, Elder G, Bozdagi O, Buxbaum J A critical role for human caspase-4 in endotoxin sensitivity. J Immunol, 2014-05-30;193(1):335-43. 2014-05-30 [PMID: 24879791] (Western Blot, Mouse)
• Zhao C, Gillette D, Li X, Zhang Z, Wen H Nuclear factor E2-related factor-2 (Nrf2) is required for NLRP3 and AIM2 inflammasome activation. J Biol Chem, 2014-05-05;289(24):17020-9. 2014-05-05 [PMID: 24798340] (Western Blot, Mouse)
• Nieto-Torres J, DeDiego M, Verdia-Baguena C, Jimenez-Guardeno J, Regla-Nava J, Fernandez-Delgado R, Castano-Rodriguez C, Alcaraz A, Torres J, Aguilella V, Enjuanes L Severe acute respiratory syndrome coronavirus envelope protein ion channel activity promotes virus fitness and pathogenesis. PLoS Pathog, 2014-05-01;10(5):e1004077. 2014-05-01 [PMID: 24788150] (Western Blot, Mouse)
• Meunier E, Dick M, Dreier R, Schurmann N, Kenzelmann Broz D, Warming S, Roose-Girma M, Bumann D, Kayagaki N, Takeda K, Yamamoto M, Broz P Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases. Nature, 2014-04-16;509(7500):366-70. 2014-04-16 [PMID: 24739961] (Western Blot, Mouse)
• Rabolli V, Wallemme L, Lo Re S, Uwambayinema F, Palmai-Pallag M, Thomassen L, Tyteca D, Octave J, Marbaix E, Lison D, Devuyst O, Huaux F Critical role of aquaporins in interleukin 1beta (IL-1beta)-induced inflammation. J Biol Chem, 2014-04-03;289(20):13937-47. 2014-04-03 [PMID: 24700466] (Western Blot, Mouse)
• Gupta R, Ghosh S, Monks B, DeOliveira R, Tzeng T, Kalantari P, Nandy A, Bhattacharjee B, Chan J, Ferreira F, Rathinam V, Sharma S, Lien E, Silverman N, Fitzgerald K, Firon A, Trieu-Cuot P, Henneke P, Golenbock D RNA and beta-hemolysin of group B Streptococcus induce interleukin-1beta (IL-1beta) by activating NLRP3 inflammasomes in mouse macrophages. J Biol Chem, 2014-04-01;289(20):13701-5. 2014-04-01 [PMID: 24692555] (Western Blot, Mouse)
• Xia M, Boini K, Abais J, Xu M, Zhang Y, Li P Endothelial NLRP3 inflammasome activation and enhanced neointima formation in mice by adipokine visfatin. Am J Pathol, 2014-03-13;184(5):1617-28. 2014-03-13 [PMID: 24631027] (IHC, Mouse)
• Kanarek N, Grivennikov S, Leshets M, Lasry A, Alkalay I, Horwitz E, Shaul Y, Stachler M, Voronov E, Apte R, Pagano M, Pikarsky E, Karin M, Ghosh S, Ben-Neriah Y Critical role for IL-1beta in DNA damage-induced mucositis. Proc Natl Acad Sci U S A, 2014-01-27;111(6):E702-11. 2014-01-27 [PMID: 24469832] (IHC, Mouse)
• Maier N, Crown D, Liu J, Leppla S, Moayeri M Arsenic trioxide and other arsenical compounds inhibit the NLRP1, NLRP3, and NAIP5/NLRC4 inflammasomes. J Immunol, 2013-12-13;192(2):763-70. 2013-12-13 [PMID: 24337744] (Western Blot, Human)
• Tanaka S, Ishii A, Ohtaki H, Shioda S, Yoshida T, Numazawa S Activation of microglia induces symptoms of Parkinson&#039;s disease in wild-type, but not in IL-1 knockout mice. J Neuroinflammation, 2013-12-01;10(0):143. 2013-12-01 [PMID: 24289537] (IHC-Fr, Mouse)
• He Y, Varadarajan S, Munoz-Planillo R, Burberry A, Nakamura Y, Nunez G 3,4-methylenedioxy-beta-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome. J Biol Chem, 2013-11-21;289(2):1142-50. 2013-11-21 [PMID: 24265316] (Western Blot, Mouse)
• Smedberg J, Westcott M, Ahmed M, Lyles D Signaling pathways in murine dendritic cells that regulate the response to vesicular stomatitis virus vectors that express flagellin. J Virol, 2013-11-06;88(2):777-85. 2013-11-06 [PMID: 24198430] (Western Blot, Mouse)
• Li B, Shi Y, Shu J, Gao J, Wu P, Tang S Wingless-type mammary tumor virus integration site family, member 5A (Wnt5a) regulates human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein 120 (gp120)-induced expression of pro-inflammatory cytokines via the Ca2+/calmodulin-dependent protein kinase II (CaMKII) and c-Jun N-terminal kinase (JNK) signaling pathways. J Biol Chem, 2013-03-28;288(19):13610-9. 2013-03-28 [PMID: 23539626] (Western Blot, Mouse)
• El-Zaatari M, Kao J, Tessier A, Bai L, Hayes M, Fontaine C, Eaton K, Merchant J Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets. PLoS ONE, 2013-03-08;8(3):e58935. 2013-03-08 [PMID: 23520544] (IHC, Mouse)
• Misawa T, Takahama M, Kozaki T, Lee H, Zou J, Saitoh T, Akira S Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome. Nat Immunol, 2013-03-17;14(5):454-60. 2013-03-17 [PMID: 23502856] (Western Blot, Mouse)
• Carmi Y, Dotan S, Rider P, Kaplanov I, White M, Baron R, Abutbul S, Huszar M, Dinarello C, Apte R, Voronov E The role of IL-1beta in the early tumor cell-induced angiogenic response. J Immunol, 2013-03-08;190(7):3500-9. 2013-03-08 [PMID: 23475218] (IHC-Fr, IHC-P, Neutralization, Mouse)
• Lee G, Subramanian N, Kim A, Aksentijevich I, Goldbach-Mansky R, Sacks D, Germain R, Kastner D, Chae J The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature, 2012-11-11;492(7427):123-7. 2012-11-11 [PMID: 23143333] (Western Blot, Mouse)
• Broz P, Ruby T, Belhocine K, Bouley D, Kayagaki N, Dixit V, Monack D Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1. Nature, 2012-08-15;490(7419):288-91. 2012-08-15 [PMID: 22895188] (Western Blot, Mouse)
• Gessner MA, Werner JL, Lilly LM, Nelson MP, Metz AE, Dunaway CW, Chan YR, Ouyang W, Brown GD, Weaver CT, Steele C Dectin-1-dependent interleukin-22 contributes to early innate lung defense against Aspergillus fumigatus. Infect. Immun., 2011-10-28;80(1):410-7. 2011-10-28 [PMID: 22038916] (Neutralization, Mouse)
• Kim D, You B, Lim H, Lee SJ Toll-like receptor 2 contributes to chemokine gene expression and macrophage infiltration in the dorsal root ganglia after peripheral nerve injury. Mol Pain, 2011-09-28;7(0):74. 2011-09-28 [PMID: 21951975] (ICC, Mouse)
• Rider P, Carmi Y, Guttman O, Braiman A, Cohen I, Voronov E, White MR, Dinarello CA, Apte RN IL-1alpha and IL-1beta recruit different myeloid cells and promote different stages of sterile inflammation. J. Immunol., 2011-09-19;187(9):4835-43. 2011-09-19 [PMID: 21930960] (ICC, IHC-Fr, Neutralization, Mouse)
• Fisher DT, Chen Q, Skitzki JJ, Muhitch JB, Zhou L, Appenheimer MM, Vardam TD, Weis EL, Passanese J, Wang WC, Gollnick SO, Dewhirst MW, Rose-John S, Repasky EA, Baumann H, Evans SS IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells. J. Clin. Invest., 2011-09-19;121(10):3846-59. 2011-09-19 [PMID: 21926464] (Neutralization, Mouse)
• Bergsbaken T, Fink SL, den Hartigh AB, Loomis WP, Cookson BT Coordinated Host Responses during Pyroptosis: Caspase-1-Dependent Lysosome Exocytosis and Inflammatory Cytokine Maturation. J. Immunol., 2011-07-29;187(5):2748-54. 2011-07-29 [PMID: 21804020] (Western Blot, Mouse)
• Carmi Y, Rinott G, Dotan S, Elkabets M, Rider P, Voronov E, Apte RN Microenvironment-derived IL-1 and IL-17 interact in the control of lung metastasis. J. Immunol., 2011-02-07;186(6):3462-71. 2011-02-07 [PMID: 21300825] (Neutralization, Mouse)
• Yoshida H, Russell J, Senchenkova EY, Almeida Paula LD, Granger DN Interleukin-1beta mediates the extra-intestinal thrombosis associated with experimental colitis. Am. J. Pathol., 2010-10-22;177(6):2774-81. 2010-10-22 [PMID: 20971730] (Neutralization, Mouse)
• Masters SL, Dunne A, Subramanian SL, Hull RL, Tannahill GM, Sharp FA, Becker C, Franchi L, Yoshihara E, Chen Z, Mullooly N, Mielke LA, Harris J, Coll RC, Mills KH, Mok KH, Newsholme P, Nunez G, Yodoi J, Kahn SE, Lavelle EC, O'Neill LA Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes. Nat. Immunol., 2010-09-12;11(10):897-904. 2010-09-12 [PMID: 20835230] (Western Blot, Mouse)
• McCoy AJ, Koizumi Y, Toma C, Higa N, Dixit V, Taniguchi S, Tschopp J, Suzuki T Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase-1 activation in macrophages. Eur. J. Immunol., 2010-10-01;40(10):2797-803. 2010-10-01 [PMID: 20722078] (Western Blot, Mouse)
• Radwan M, Stiefvater R, Grunert T, Sharif O, Miller I, Marchetti-Deschmann M, Allmaier G, Gemeiner M, Knapp S, Kovarik P, Muller M, Strobl B Tyrosine kinase 2 controls IL-1beta production at the translational level. J. Immunol., 2010-08-16;185(6):3544-53. 2010-08-16 [PMID: 20713887] (Western Blot, Mouse)
• Ohno T, Oboki K, Kajiwara N, Morii E, Aozasa K, Flavell RA, Okumura K, Saito H, Nakae S Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages. J. Immunol., 2009-12-15;183(12):7890-7. 2009-12-15 [PMID: 19933859] (MUSTag PCR Assay, Mouse)
• Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C, Vermaelen K, Panaretakis T, Mignot G, Ullrich E, Perfettini JL, Schlemmer F, Tasdemir E, Uhl M, Genin P, Civas A, Ryffel B, Kanellopoulos J, Tschopp J, Andre F, Lidereau R, McLaughlin NM, Haynes NM, Smyth MJ, Kroemer G, Zitvogel L Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat. Med., 2009-09-20;15(10):1170-8. 2009-09-20 [PMID: 19767732] (Neutralization, Mouse)
• Martin U, Scholler J, Gurgel J, Renshaw B, Sims JE, Gabel CA Externalization of the leaderless cytokine IL-1F6 occurs in response to lipopolysaccharide/ATP activation of transduced bone marrow macrophages. J. Immunol., 2009-08-28;183(6):4021-30. 2009-08-28 [PMID: 19717513] (Western Blot, Mouse)
• Babelova A, Moreth K, Tsalastra-Greul W, Zeng-Brouwers J, Eickelberg O, Young MF, Bruckner P, Pfeilschifter J, Schaefer RM, Schaefer R, Grone HJ, Schaefer L Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors. J Biol Chem, 2009-07-15;284(36):24035-48. 2009-07-15 [PMID: 19605353] (IHC-P, Mouse)
• Hyvarinen K, Tuomainen AM, Laitinen S, Bykov IL, Tormakangas L, Lindros K, Käkelä R, Alfthan G, Salminen I, Jauhiainen M, Kovanen PT, Leinonen M, Saikku P, Pussinen PJ Chlamydial and periodontal pathogens induce hepatic inflammation and fatty acid imbalance in apolipoprotein E-deficient mice. Infect. Immun., 2009-05-18;77(8):3442-9. 2009-05-18 [PMID: 19451238] (IHC-P, Mouse)
• Maelfait J, Vercammen E, Janssens S, Schotte P, Haegman M, Magez S, Beyaert R Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8. J. Exp. Med., 2008-08-25;205(9):1967-73. 2008-08-25 [PMID: 18725521] (Western Blot, Mouse)
• Das S, Mishra MK, Ghosh J, Basu A Japanese Encephalitis Virus infection induces IL-18 and IL-1beta in microglia and astrocytes: correlation with in vitro cytokine responsiveness of glial cells and subsequent neuronal death. J. Neuroimmunol., 2008-03-28;195(1):60-72. 2008-03-28 [PMID: 18374991] (IHC-Fr, Western Blot, Mouse)
• Pozsgai G, Sandor K, Perkecz A, Szolcsanyi J, Helyes Z, Brain SD, Pinter E Topical acetone treatment induces neurogenic oedema on the sensitized mouse ear: an in vivo study using transient receptor potential vanilloid 1 (TRPV1) receptor knockout mice. Inflamm. Res., 2007-11-01;56(11):459-67. 2007-11-01 [PMID: 18224287] (Neutralization, Mouse)
• Miller LS, Pietras EM, Uricchio LH, Hirano K, Rao S, Lin H, O'Connell RM, Iwakura Y, Cheung AL, Cheng G, Modlin RL Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo. J. Immunol., 2007-11-15;179(10):6933-42. 2007-11-15 [PMID: 17982084] (Western Blot, Mouse)
• Ogiso T, Nagaki M, Takai S, Tsukada Y, Mukai T, Kimura K, Moriwaki H Granulocyte colony-stimulating factor impairs liver regeneration in mice through the up-regulation of interleukin-1beta. J. Hepatol., 2007-08-10;47(6):816-25. 2007-08-10 [PMID: 17869372] (Neutralization, Mouse)
• Medeiros MM, Peixoto JR, Oliveira AC, Cardilo-Reis L, Koatz VL, Van Kaer L, Previato JO, Mendonca-Previato L, Nobrega A, Bellio M Toll-like receptor 4 (TLR4)-dependent proinflammatory and immunomodulatory properties of the glycoinositolphospholipid (GIPL) from Trypanosoma cruzi. J. Leukoc. Biol., 2007-05-31;82(3):488-96. 2007-05-31 [PMID: 17540734] (Neutralization, Mouse)
• Shchors K, Shchors E, Rostker F, Lawlor ER, Brown-Swigart L, Evan GI The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta. Genes Dev., 2006-09-15;20(18):2527-38. 2006-09-15 [PMID: 16980582] (Neutralization, Mouse)
• Perrin FE, Lacroix S, Aviles-Trigueros M, David S Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha and interleukin-1beta in Wallerian degeneration. Brain, 2005-02-02;128(0):854-66. 2005-02-02 [PMID: 15689362] (Neutralization, Mouse)
• Banks WA, Farr SA, La Scola ME Intravenous human interleukin-1alpha impairs memory processing in mice: dependence on blood-brain barrier transport into posterior division of the septum. J. Pharmacol. Exp. Ther., 2001-11-01;299(2):536-41. 2001-11-01 [PMID: 11602664] (Neutralization, Mouse)

Reviews for IL-1 beta/IL-1F2 Antibody (AF-401-NA) (3)

Average Rating: 4.3

(Based on 3 reviews)

We have 3 reviews tested in 1 species: Mouse.

reviewed by: Verified Customer WB Mouse 01/08/2015

Summary

• Application: Western Blot
• Sample Tested: See PMID 23160153
• Species: Mouse

reviewed by: Verified Customer ICC Mouse 01/08/2015

Summary

• Application: Immunocytochemistry
• Sample Tested: See PMID 23920123
• Species: Mouse

reviewed by: Verified Customer ELISA Mouse 01/08/2015

Summary

• Application: ELISA
• Sample Tested: See PMID 21709053
• Species: Mouse

Bioinformatics

• Gene Symbol: IL1B
• Uniprot:
  • NP_032387()