Mouse reactivity reported in scientific literature (PMID: 28765552). Cross-reacts with Human. It will cross-react with mouse and rat IkB alpha, based on BLAST.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS containing 0.2% gelatin
0.05% Sodium Azide
Protein G purified
Alternate Names for IkB-alpha Antibody
IkappaBalphaNF-kappa-B inhibitor alpha
Major histocompatibility complex enhancer-binding protein MAD3
nuclear factor of kappa light chain gene enhancer in B-cells
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor
NF-kB is silenced in the cytoplasm by an inhibitory protein, IkB (1). Synthesis of IkB alpha is autoregulated (2). IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g (3-6). External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Six members of IkB family members have been identified (1). One of the first genes induced following NF-kB activation is IkB alpha.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Inhibitor kappa B-alpha (IkappaB-alpha) The transcription factor nuclear factor kappa beta (NFkB) is highly regulated by triggers such as stress, free-radicals, UV light, and hypoxia. NFkB is one of the fastest responding transcription factors in humans. The NFKB signaling pathway is ess... Read full blog post.
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